EM · Paediatric rashes and febrile illness
Paediatric rashes and febrile illness
Also known as Febrile rash · Paediatric exanthem · Meningococcal rash · Kawasaki disease · Henoch-Schonlein purpura · IgA vasculitis
The febrile child with a rash is a high-stakes presentation because a small number of rashes signal time-critical disease while the majority are benign viral exanthems. The Fellowship candidate must read rash morphology first: a non-blanching petechial or purpuric rash with fever is meningococcal septicaemia until proven otherwise and earns ceftriaxone 50 mg per kilogram intravenously immediately, while a fever of five days or more with bilateral non-purulent conjunctivitis, a polymorphous rash, a strawberry tongue and swollen hands is Kawasaki disease, treated with intravenous immunoglobulin 2 g per kilogram and aspirin within ten days of fever onset to prevent coronary artery aneurysm. Measles descends from the hairline after a prodrome of fever, coryza, cough and conjunctivitis with Koplik spots; chickenpox is a vesicular rash in crops at different stages; erythema multiforme is a target rash with at most one mucosal site; and Henoch-Schonlein purpura is a palpable purpura on the lower limbs with abdominal pain, arthritis and renal involvement. The differential is the viral exanthem, the drug reaction and the autoimmune vasculitis, distinguished by morphology, tempo, distribution and toxicity. ACEM-primary, globally tagged.
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8 MCQs with explanations
Target exams
Red flags
Related topics
- Paediatric fever and serious bacterial illness (the febrile child in the emergency department)
- Paediatric sepsis and septic shock (the septic child in the emergency department)
- The sick child and paediatric resuscitation
- Paediatric respiratory distress — croup, bronchiolitis and acute asthma
- Sepsis and septic shock — the emergency department approach
Meet the patient
A two-year-old is brought to the resuscitation bay with a six-hour history of fever and irritability and a rapidly spreading purpuric rash over the trunk and limbs. He is lethargic, with cool mottled peripheries, a capillary refill of five seconds and a heart rate of 160; the rash is non-blanching on the glass test. The registrar is drawing up blood-culture bottles and is debating whether to call radiology for a scan before giving the antibiotic.[1]
In the next bay, a four-year-old girl has had fever for six days that has not responded to two courses of oral antibiotics. Her eyes are red without discharge, her lips are cracked and fissured and her tongue is strawberry-red, and her palms and soles are erythematous and oedematous. The registrar has labelled it a viral illness and is about to discharge her.[2]
Two questions decide the next hour for both of these children and every febrile rash you meet: is this rash non-blanching? (ceftriaxone now) and has this fever been present for five days or more with any Kawasaki feature? (intravenous immunoglobulin and aspirin within ten days). Hold those two and the febrile rash becomes manageable.[1][2]
You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the Emergency Medicine fellowship atlas.
References18Show ledgerHide ledger
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- [2]McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association Circulation, 2017.PMID 28356445
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- [13]Newburger JW, Takahashi M, Beiser AS, et al. The treatment of Kawasaki syndrome with intravenous gamma globulin N Engl J Med, 1986.PMID 2426590
- [14]Newburger JW, Takahashi M, Burns JC, et al. A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome N Engl J Med, 1991.PMID 1709446
- [15]Kanegaye JT, Soliemanzadeh P, Bradley JS Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatment Pediatrics, 2001.PMID 11694698
- [16]Whitley RJ Neonatal herpes simplex virus infection Curr Opin Infect Dis, 2004.PMID 15166828
- [17]Wong SS, Yip CC, Lau SK, Yuen KY Human enterovirus 71 and hand, foot and mouth disease Epidemiol Infect, 2010.PMID 20056019
- [18]Jasic M, Subat-Dezulovic M, Nikolic H, et al. Henoch-Schonlein purpura complicated by appendicitis, intussusception and ureteritis Coll Antropol, 2011.PMID 21661371