Chemotherapy and supportive pharmacology

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Target exams

Red flags

• Vincristine prepared or delivered by the intrathecal route — a uniformly fatal administration error that must never occur
• An anthracycline such as doxorubicin or daunorubicin given without a documented cumulative-dose record and cardiac surveillance plan
• Anthracycline extravasation managed with cold compresses rather than dexrazoxane — cold worsens vinca injury and cold is wrong for anthracycline
• Ondansetron given in large intravenous doses without awareness of dose-related QT prolongation
• A child on chemotherapy presenting with febrile neutropenia treated as a routine viral illness rather than a medical emergency
• Dexrazoxane withheld because of an out-of-date fear of secondary malignancy when the child is receiving a high cumulative anthracycline dose

Life stages

Care settings

Clinical exam formats

Board mappings

• General and Community Paediatrics
• Allergy and Immunology
• Current 2026 PREP curriculum — Learning Objective: Safe prescribing and medication management in infants, children and young people
• Current 2026 PREP curriculum — Learning Objective 2.2.1: Recognise, prioritise and manage an acutely ill infant, child or young person
• Renewed curriculum for first-year trainees from 2027 — Learning goal 6: Clinical management – essential general paediatrics
• Renewed curriculum for first-year trainees from 2027 — Learning goal 9: Quality and safety, including medication safety
• Clinical Applications
• Medical Sciences
• Long Cases
• Short Cases
• 4. Professional skills and knowledge: Patient management
• 7. Patient safety, including safe prescribing
• 8. Quality improvement and patient safety
• General Paediatrics: Understands cytotoxic chemotherapy classes, supportive care medicines, and the non-negotiable vincristine-intrathecal safety rule
• Foundation of Practice (FOP)
• Theory and Science (TAS)
• Applied Knowledge in Practice (AKP)
• Clinical
• History
• Communication
• General Pediatrics Content Outline — Domain 10: Principles of Pharmacology and Medication Management
• General Pediatrics Content Outline — Universal Task 4: Management and Treatment
• General Pediatrics Content Outline — Universal Task 2: Health Maintenance
• Systems-Based Practice 2: Coordinated chronic disease care
• Patient Safety/Quality Improvement 1: Medication Safety
• Medical Knowledge 2: Diagnostic and Therapeutic Decision Making
• Medical Expert
• Collaborator
• Pediatrics: Core EPA #5 — Recommending and Initiating Pharmacologic Interventions