Paeds Cases · clinical-pharmacology-and-therapeutics
Chemotherapy and supportive pharmacology — formative case
A MedVellum formative structured clinical encounter following a child starting a doxorubicin and cisplatin regimen, assessing the dexrazoxane cardioprotection decision, the antiemetic ladder, febrile neutropenia prophylaxis and the front-door plan, and the non-negotiable vincristine-intravenous-only route rule. It is not an official board format.
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This is one MedVellum formative structured clinical encounter. The scoring, prompts and performance descriptions are educational feedback tools. They are not an official college station, timing, mark allocation, pass score or reproduced examination format. The encounter assesses the dexrazoxane cardioprotection decision, the antiemetic ladder for a highly emetogenic regimen, colony-stimulating factor prophylaxis and the febrile-neutropenia front-door plan, the vincristine-intravenous-only route rule, and family communication. [1] [3]
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- [1]Lipshultz SE; Rifai N; Dalton VM; Levy DE; Silverman LB; Lipsitz SR The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia The New England journal of medicine, 2004.PMID 15247354
- [2]Dupuis LL; Sung L; Molassiotis A; Orsey AD; Tissing W; van de Wetering M 2016 updated MASCC/ESMO consensus recommendations: Prevention of acute chemotherapy-induced nausea and vomiting in children Supportive care in cancer, 2017.PMID 27565788
- [3]Smith TJ; Khatcheressian J; Lyman GH; Ozer H; Armitage JO; Balducci L 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline Journal of clinical oncology, 2006.PMID 16682719
- [4]Mouridsen HT; Langer SW; Buter J; Eidtmann H; Rosti G; de Wit M Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies Annals of oncology, 2007.PMID 17185744
- [5]DeVine A; Landier W; Hudson MM; Constine LS; Bhatia S; Armenian SH The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers: A Review JAMA oncology, 2025.PMID 39976936