EM · Toxicology and environmental emergencies
Alcohol and benzodiazepine withdrawal (emergency department recognition and management)
Also known as Alcohol withdrawal syndrome · Delirium tremens · Alcohol withdrawal seizure · Benzodiazepine withdrawal · CIWA-Ar withdrawal · Alcohol hallucinosis
ACEM emergency-department approach to alcohol and benzodiazepine withdrawal: GABA-glutamate pathophysiology, staged clinical presentation through to delirium tremens, CIWA-Ar-guided benzodiazepine-ladder management, and the thiamine-before-glucose safety rule.
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8 MCQs with explanations
Target exams
Red flags
Related topics
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Meet the patient
A 52-year-old man is brought to the emergency department 30 hours after his last drink. He is tremulous, diaphoretic and agitated, heart rate 128, blood pressure 178 over 104, temperature 38.1. He reports vivid visual hallucinations but is oriented to person and place. His bedside glucose is 4.2. The CIWA-Ar is 23.[1]
The two questions that decide his next hour are the two that decide every withdrawal case: how severe is the unopposed excitatory state? (the CIWA-Ar answers, and 23 is severe) and have I excluded the killers that mimic withdrawal? (sepsis, hyponatraemia, hypoglycaemia, hepatic encephalopathy, Wernicke, an intracranial bleed). Hold those two and the whole ladder slots into place.[1][6]
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References22Show ledgerHide ledger
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- [2]Mayo-Smith MF Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal JAMA, 1997.PMID 9214531
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