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EM TopicsComa

EM · Coma

Coma and GCS assessment

Also known as GCS · Altered conscious level · Decreased conscious state · Unconscious patient

The comatose patient and the Glasgow Coma Scale — the structured approach (the ABCDE, the rapid glucose, the reversible causes), the GCS (the eye, the verbal, the motor components; the best motor response is the most sensitive), the AVPU for the rapid triage, the differential (the toxic-metabolic, the structural, the infectious), the immediate investigations (the glucose, the blood gas, the CT, the drug screen), and the management (the airway, the naloxone, the thiamine, the specific antidote). ACEM-primary, globally tagged.

high26 referencesUpdated 13 Oct 202619 min readSource-verified · Oct 2026

Checked against its sources on 13 Oct 2026

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ACEMFRCEMABEMFRCPCCCFPEMEBEEM

Red flags

  • The hypoglycaemia is the commonest rapidly reversible cause of the coma — check the glucose immediately in every comatose patient
  • The opioid overdose (the pin-point pupils, the reduced respiratory rate) responds to naloxone titrated to ventilation — give it early
  • A comatose patient with the asymmetric pupils or the unilateral weakness has a structural intracranial lesion until proven otherwise
  • The alcoholic patient may have the Wernicke encephalopathy — give thiamine before the glucose
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Related topics

  • Subarachnoid haemorrhage
  • Meningitis and encephalitis (emergency department diagnosis and management)
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Your progress

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Practise this topic8 MCQs with explanations

Target exams

ACEMFRCEMABEMFRCPCCCFPEMEBEEM

Red flags

  • The hypoglycaemia is the commonest rapidly reversible cause of the coma — check the glucose immediately in every comatose patient
  • The opioid overdose (the pin-point pupils, the reduced respiratory rate) responds to naloxone titrated to ventilation — give it early
  • A comatose patient with the asymmetric pupils or the unilateral weakness has a structural intracranial lesion until proven otherwise
  • The alcoholic patient may have the Wernicke encephalopathy — give thiamine before the glucose
The one-line answer

The comatose patient is resuscitated, glucose-checked, and antidote-treated in parallel — the airway first, the finger-prick glucose the moment you reach D of the ABCDE, and naloxone, glucose and thiamine given empirically where the cause is unclear. Only naloxone survives as a routine empirical component — experts discourage flumazenil in the cocktail. The GCS is reported as components (E, V, M), never as a total alone, because the motor response carries most of the scale's predictive information; a comatose patient with asymmetric pupils or a unilateral weakness has a structural lesion until proven otherwise.[1][24]

Meet the patient

A 58-year-old man is found unconscious at home, brought in by ambulance. His eyes open only to the supraorbital press, he makes no sound, the right arm withdraws to a supraorbital press while the left arm extends rigidly with adduction and internal rotation. The glucose is 6.4, the pupils 3 mm and briskly reactive, the respiratory rate 6. The story is not yet told by the history — it is told by the asymmetric motor response, and it points at a structural intracranial lesion until the CT says otherwise.[1]

The two questions that govern every coma are two first five minutes answer: is there a rapidly reversible cause? (the glucose, the opioid, the thiamine) and is this toxic-metabolic or structural? (the pupils decide — equal and reactive is metabolic, asymmetric or fixed is structural). Hold those two and everything below slots into place.[1]

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References26ShowHide
  1. [1]Soares BP, Shih RY, Utukuri PS, et al. ACR Appropriateness Criteria® Altered Mental Status, Coma, Delirium, and Psychosis: 2024 Update J Am Coll Radiol, 2024.PMID 39488349
  2. [2]Llorens P, Cano S, Espinosa B, et al. Prevalence, risk factors, and prognosis of the need for physical and chemical restraint in older patients attending emergency departments. EDEN-50 Am J Emerg Med, 2026.PMID 42000676
  3. [3]Teasdale G, Maas A, Lecky F, et al. The Glasgow Coma Scale at 40 years: standing the test of time Lancet Neurol, 2014.PMID 25030516
  4. [4]Aguilar-Fuentes V, Orozco-Puga P, Jiménez-Ruiz A The Glasgow Coma Scale: 50-year anniversary Neurol Sci, 2024.PMID 38436790
  5. [5]Wijdicks EFM, Bamlet WR, Maramattom BV, et al. Validation of a new coma scale: The FOUR score Ann Neurol, 2005.PMID 16178024
  6. [6]Sandroni C, D'Arrigo S, Cacciola S, et al. Prediction of poor neurological outcome in comatose survivors of cardiac arrest: a systematic review Intensive Care Med, 2020.PMID 32915254
  7. [7]Scarpino M, Lolli F, Lanzo G, et al. Do changes in SSEP amplitude over time predict the outcome of comatose survivors of cardiac arrest? Resuscitation, 2022.PMID 36375653
  8. [8]Hall WA, Munakomi S Uncal Herniation StatPearls, 2026.PMID 30725793
  9. [9]Bodien YG, Allanson J, Cardone P, et al. Cognitive Motor Dissociation in Disorders of Consciousness N Engl J Med, 2024.PMID 39141852
  10. [10]Ahmed FW, Majeed MS, Kirresh O. Non-Diabetic Hypoglycemia StatPearls, 2026.PMID 34424652
  11. [11]Singh J, Regina AC. Wernicke Encephalopathy StatPearls, 2026.PMID 29261914
  12. [12]Kim HK, Nelson LS. Reducing the harm of opioid overdose with the safe use of naloxone: a pharmacologic review Expert Opin Drug Saf, 2015.PMID 25865597
  13. [13]Sivilotti MLA. Flumazenil, naloxone and the 'coma cocktail' Br J Clin Pharmacol, 2016.PMID 26469689
  14. [14]Veiraiah A, Dyas J, Cooper G, et al. Flumazenil use in benzodiazepine overdose in the UK: a retrospective survey of NPIS data Emerg Med J, 2012.PMID 21785147
  15. [15]Krebs L, Durden B, Saguil A. Aseptic and Bacterial Meningitis: Diagnosis, Treatment, and Prevention Am Fam Physician, 2026.PMID 41839077
  16. [16]McGill F, Heyderman RS, Panagiotou S, et al. Acute bacterial meningitis in adults Lancet, 2016.PMID 27265346
  17. [17]Munakomi S, Das JM. Brain Herniation StatPearls, 2026.PMID 31194403
  18. [18]Nehring SM, Tadi P, Tenny S. Cerebral Edema StatPearls, 2026.PMID 30725957
  19. [19]Faiver L, Hensler D, Rush SC, et al. Safety and Efficacy of 23.4% Sodium Chloride Administered via Peripheral Venous Access for the Treatment of Cerebral Herniation and Intracranial Pressure Elevation Neurocrit Care, 2021.PMID 34173156
  20. [20]Seifert AN. Cushing's reflex due to spontaneous pneumocephalus after forceful nose blowing: A case report Am J Emerg Med, 2026.PMID 42263335
  21. [21]Antolini R, Violini F, Domizi R, et al. Early Antibiotic Prophylaxis in Comatose Patients to Prevent Early-Onset Ventilator-Associated Pneumonia: A Systematic Review and Bayesian Meta-Analysis Antibiotics (Basel), 2026.PMID 42353745
  22. [22]Costerus JM, Brouwer MC, Sprengers MES, et al. Cranial Computed Tomography, Lumbar Puncture, and Clinical Deterioration in Bacterial Meningitis: A Nationwide Cohort Study Clin Infect Dis, 2018.PMID 29522090
  23. [23]McNarry AF, Goldhill DR. Simple bedside assessment of level of consciousness: comparison of two simple assessment scales with the Glasgow Coma scale Anaesthesia, 2004.PMID 14687096
  24. [24]Healey C, Osler TM, Rogers FB, et al. Improving the Glasgow Coma Scale score: motor score alone is a better predictor J Trauma, 2003.PMID 12707528
  25. [25]Sessler CN, et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med, 2002.PMID 12421743
  26. [26]Jain H, et al. Comparing the Full Outline of Unresponsiveness (FOUR) score and the Glasgow Coma Scale (GCS) for predicting outcomes in traumatic brain injury: a comparative study. J Trauma Inj, 2025.PMID 41492901

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Related topics

  • Subarachnoid haemorrhage
  • Meningitis and encephalitis (emergency department diagnosis and management)