EM · Coma
Coma and GCS assessment
Also known as GCS · Altered conscious level · Decreased conscious state · Unconscious patient
The comatose patient and the Glasgow Coma Scale — the structured approach (the ABCDE, the rapid glucose, the reversible causes), the GCS (the eye, the verbal, the motor components; the best motor response is the most sensitive), the AVPU for the rapid triage, the differential (the toxic-metabolic, the structural, the infectious), the immediate investigations (the glucose, the blood gas, the CT, the drug screen), and the management (the airway, the naloxone, the thiamine, the specific antidote). ACEM-primary, globally tagged.
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8 MCQs with explanations
Target exams
Red flags
Meet the patient
A 58-year-old man is found unconscious at home, brought in by ambulance. His eyes stay shut, he makes no sound, the right arm withdraws to a supraorbital press while the left arm extends rigidly with adduction and internal rotation. The glucose is 6.4, the pupils 3 mm and briskly reactive, the respiratory rate 6. The story is not yet told by the history — it is told by the asymmetric motor response, and it points at a structural intracranial lesion until the CT says otherwise.[1]
The two questions that govern every coma are the two the first five minutes answer: is there a rapidly reversible cause? (the glucose, the opioid, the thiamine) and is this toxic-metabolic or structural? (the pupils decide — equal and reactive is metabolic, asymmetric or fixed is structural). Hold those two and everything below slots into place.[1]
You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the Emergency Medicine fellowship atlas.
References22Show ledgerHide ledger
- [1]Soares BP, Shih RY, Utukuri PS, et al. ACR Appropriateness Criteria® Altered Mental Status, Coma, Delirium, and Psychosis: 2024 Update J Am Coll Radiol, 2024.PMID 39488349
- [2]Llorens P, Cano S, Espinosa B, et al. Prevalence, risk factors, and prognosis of the need for physical and chemical restraint in older patients attending emergency departments. EDEN-50 Am J Emerg Med, 2026.PMID 42000676
- [3]Teasdale G, Maas A, Lecky F, et al. The Glasgow Coma Scale at 40 years: standing the test of time Lancet Neurol, 2014.PMID 25030516
- [4]Aguilar-Fuentes V, Orozco-Puga P, Jiménez-Ruiz A The Glasgow Coma Scale: 50-year anniversary Neurol Sci, 2024.PMID 38436790
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- [8]Hall WA, Munakomi S Uncal Herniation 2026.PMID 30725793
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- [11]Singh J, Regina AC. Wernicke Encephalopathy StatPearls, 2026.PMID 29261914
- [12]Kim HK, Nelson LS. Reducing the harm of opioid overdose with the safe use of naloxone: a pharmacologic review Expert Opin Drug Saf, 2015.PMID 25865597
- [13]Sivilotti MLA. Flumazenil, naloxone and the 'coma cocktail' Br J Clin Pharmacol, 2016.PMID 26469689
- [14]Veiraiah A, Dyas J, Cooper G, et al. Flumazenil use in benzodiazepine overdose in the UK: a retrospective survey of NPIS data Emerg Med J, 2012.PMID 21785147
- [15]Krebs L, Durden B, Saguil A. Aseptic and Bacterial Meningitis: Diagnosis, Treatment, and Prevention Am Fam Physician, 2026.PMID 41839077
- [16]McGill F, Heyderman RS, Panagiotou S, et al. Acute bacterial meningitis in adults Lancet, 2016.PMID 27265346
- [17]Munakomi S, Das JM. Brain Herniation StatPearls, 2026.PMID 31194403
- [18]Nehring SM, Tadi P, Tenny S. Cerebral Edema StatPearls, 2026.PMID 30725957
- [19]Faiver L, Hensler D, Rush SC, et al. Safety and Efficacy of 23.4% Sodium Chloride Administered via Peripheral Venous Access for the Treatment of Cerebral Herniation and Intracranial Pressure Elevation Neurocrit Care, 2021.PMID 34173156
- [20]Seifert AN. Cushing's reflex due to spontaneous pneumocephalus after forceful nose blowing: A case report Am J Emerg Med, 2026.PMID 42263335
- [21]Antolini R, Violini F, Domizi R, et al. Early Antibiotic Prophylaxis in Comatose Patients to Prevent Early-Onset Ventilator-Associated Pneumonia: A Systematic Review and Bayesian Meta-Analysis Antibiotics (Basel), 2026.PMID 42353745
- [22]Costerus JM, Brouwer MC, Sprengers MES, et al. Cranial Computed Tomography, Lumbar Puncture, and Clinical Deterioration in Bacterial Meningitis: A Nationwide Cohort Study Clin Infect Dis, 2018.PMID 29522090