Paeds · paediatric-dermatology

Skin manifestations of systemic disease

Also known as Cutaneous signs of systemic disease · Dermatologic markers of internal disease · Skin as a window to systemic disease · Neurocutaneous syndromes · Reactive erythemas · Paraneoplastic dermatoses

Fellowship topic on cutaneous manifestations of systemic disease in children: the skin as a window to internal disease. Covers the reactive erythemas and panniculitides (erythema nodosum signalling streptococcal infection, sarcoidosis and inflammatory bowel disease; erythema multiforme and mycoplasma-induced rash and mucositis after HSV and Mycoplasma; Gianotti-Crosti papular acrodermatitis as a viral exanthem), the neutrophilic dermatoses (Sweet syndrome and pyoderma gangrenosum linked to inflammatory bowel disease and malignancy), the metabolic and endocrine markers (acanthosis nigricans as insulin resistance and obesity and type 2 diabetes; necrobiosis lipoidica and xanthomas), the gastrointestinal and nutritional dermatoses (dermatitis herpetiformis as the cutaneous face of coeliac disease; acrodermatitis enteropathica as zinc deficiency), the haematological and neoplastic markers (petechiae and purpura in leukaemia and septicaemia, the blueberry muffin neonate), and the neurocutaneous phakomatoses (neurofibromatosis type 1 with its revised diagnostic criteria, tuberous sclerosis complex and the port-wine stain of Sturge-Weber syndrome). Built around recognise, investigate the underlying disease, and refer, grounded in the erythema nodosum and erythema multiforme and acanthosis nigricans reviews, the coeliac disease ESsCD guideline, the dermatitis herpetiformis update, the revised NF1 and updated TSC diagnostic criteria, the port-wine birthmark and Sweet syndrome reviews, the acrodermatitis enteropathica paper and the Gianotti-Crosti review.