Paeds · growth-development-and-behaviour
General movements assessment and Hammersmith infant neurological examination
Also known as GMA · General Movements Assessment · Prechtl general movements · HINE · Hammersmith Infant Neurological Examination · Brief-HINE · Early detection of cerebral palsy tools
Fellowship approach to Prechtl general movements assessment and the Hammersmith Infant Neurological Examination: timing windows, what each tool assesses, combination with neuroimaging for high-probability cerebral palsy, pitfalls, training limits and counselling.
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Red flags
- Absent fidgety movements on trained GMs assessment in the fidgety window
- Cramped-synchronised general movements in the writhing period
- Persistently low HINE optimality scores in a trained clinic with perinatal risk
- False reassurance from a single early normal exam when residual high risk remains
- Untrained scoring of GMs video treated as definitive prognosis
- Evolving encephalopathy, seizures or regression during the surveillance window
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- Developmental Paediatrics
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A four-month corrected-age graduate of extreme prematurity lies on a mat. The video looks “busy,” yet a trained scorer says fidgety movements are absent. The Hammersmith score is low. MRI already showed white-matter injury. Parents ask whether this is cerebral palsy. Your job on this page is not to re-teach the whole CP classification leaf. Your job is to use general movements assessment (GMA/GMs) and the Hammersmith Infant Neurological Examination (HINE) correctly: what they are, when to use them, what they do and do not prove, and how results change counselling and referral. [1] [5] [12]
This leaf owns the tools. Companion pages own CP phenotype/function labels, long-term surveillance, normal motor variation, and hypotonia work-up. [1]
Overview & Definition
General movements are spontaneous, endogenously generated whole-body movements present from fetal life through early infancy. Prechtl’s functional assessment treats the quality of those movements — fluency, variability, complexity — as a window into central motor network integrity. The method is often called Prechtl’s general movements assessment or GMA. It is not a checklist of milestones. It is a trained observation of how the infant moves when free and alert. [4] [5]
Two broad age periods matter in clinical teaching. In the writhing period (term age into the first weeks post-term), movements have a writhing character. Cramped-synchronised patterns in this window are a high-risk qualitative abnormality. In the fidgety period (commonly taught as roughly 9–20 weeks post-term age, peaking around three to five months corrected), small circular movements of neck, trunk and limbs appear in normal infants. Absent fidgety movements are strongly associated with later cerebral palsy risk when scored by trained assessors. Abnormal fidgety quality can also flag later minor neurological dysfunction pathways. [4] [5] [14]
The Hammersmith Infant Neurological Examination (HINE) is a standardised neurological examination for infants, classically used from about two to twenty-four months of age. Items cover cranial nerve function, posture, movements, tone and reflexes. Scores yield an optimality profile: lower optimality associates with higher probability of adverse motor outcomes, including cerebral palsy, when used in trained hands and interpreted with age and population context. A Brief-HINE screening adaptation exists for settings that cannot always complete a full exam. Scoring aids support consistent early-detection practice. Do not invent a single universal numeric cut-off in a viva unless you can defend the exact age band and source. State the principle: suboptimal optimality plus risk plus abnormal movements raises probability. [6] [7] [8] [9]
Together with perinatal risk and neuroimaging, GMs and HINE underpin modern early, high-probability cerebral palsy pathways. They support action before independent walking. They do not replace clinical judgement, family partnership or differential diagnosis for progressive disease. [1] [3] [18]
References18ShowHide
- [1]Novak I Early, Accurate Diagnosis and Early Intervention in Cerebral Palsy: Advances in Diagnosis and Treatment. JAMA pediatrics, 2017.PMID 28715518
- [2]Bosanquet M A systematic review of tests to predict cerebral palsy in young children. Developmental medicine and child neurology, 2013.PMID 23574478
- [3]Morgan C The Pooled Diagnostic Accuracy of Neuroimaging, General Movements, and Neurological Examination for Diagnosing Cerebral Palsy Early in High-Risk Infants: A Case Control Study. Journal of clinical medicine, 2019.PMID 31694305
- [4]Prechtl HF State of the art of a new functional assessment of the young nervous system. An early predictor of cerebral palsy. Early human development, 1997.PMID 9467689
- [5]Einspieler C Cerebral Palsy: Early Markers of Clinical Phenotype and Functional Outcome. Journal of clinical medicine, 2019.PMID 31590221
- [6]Haataja L Optimality score for the neurologic examination of the infant at 12 and 18 months of age. The Journal of pediatrics, 1999.PMID 10431108
- [7]Romeo DM Hammersmith Infant Neurological Examination in infants born at term: Predicting outcomes other than cerebral palsy. Developmental medicine and child neurology, 2022.PMID 35201619
- [8]Fehlings D The Hammersmith Infant Neurological Exam Scoring Aid supports early detection for infants with high probability of cerebral palsy. Developmental medicine and child neurology, 2024.PMID 38818710
- [9]Romeo DM Neurological assessment tool for screening infants during the first year after birth: The Brief-Hammersmith Infant Neurological Examination. Developmental medicine and child neurology, 2024.PMID 38287208
- [10]Morgan C Early Intervention for Children Aged 0 to 2 Years With or at High Risk of Cerebral Palsy: International Clinical Practice Guideline Based on Systematic Reviews. JAMA pediatrics, 2021.PMID 33999106
- [11]Morgan C Effectiveness of motor interventions in infants with cerebral palsy: a systematic review. Developmental medicine and child neurology, 2016.PMID 27027732
- [12]Te Velde A Age of Diagnosis, Fidelity and Acceptability of an Early Diagnosis Clinic for Cerebral Palsy: A Single Site Implementation Study. Brain sciences, 2021.PMID 34439692
- [13]te Velde A Early Diagnosis and Classification of Cerebral Palsy: An Historical Perspective and Barriers to an Early Diagnosis. Journal of clinical medicine, 2019.PMID 31623303
- [14]Einspieler C Are abnormal fidgety movements an early marker for complex minor neurological dysfunction at puberty? Early human development, 2007.PMID 17129688
- [15]Ferrari F General movements in full-term infants with perinatal asphyxia are related to Basal Ganglia and thalamic lesions. The Journal of pediatrics, 2011.PMID 21232764
- [16]Kwong AK Early high risk of cerebral palsy classification is predictive of cerebral palsy at 2 years: an implementation cohort study. Archives of disease in childhood, 2025.PMID 40877021
- [17]Morgan C Enriched environments and motor outcomes in cerebral palsy: systematic review and meta-analysis. Pediatrics, 2013.PMID 23958771
- [18]Rosenbaum P A report: the definition and classification of cerebral palsy April 2006. Developmental medicine and child neurology. Supplement, 2007.PMID 17370477