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EM TopicsRadiation and chemical exposure

EM · Radiation and chemical exposure

Radiation and chemical exposure

Also known as CBRN exposure · Acute radiation syndrome · Nerve agent poisoning · Sulfur mustard exposure · Chemical casualty management

Radiation and chemical exposure — the receiving-hospital side of a CBRN incident. The topic pairs two threats the Fellowship candidate must hold together: ionizing radiation, whose whole-body dose produces the acute radiation syndrome (prodromal nausea and vomiting within hours, marrow suppression and pancytopenia over days to weeks, cutaneous burns), and the chemical warfare and industrial agents — nerve agents that inhibit acetylcholinesterase, the vesicant sulfur mustard, and cyanide. The single most tested decision is decontamination before any casualty crosses the emergency-department threshold: remove the clothing to clear the majority of the contaminant, shower with water and soap, contain the runoff, and protect the staff in personal protective equipment. The antidotes are narrow and must be named with dose and route — atropine 2 mg and pralidoxime 30 mg per kilogram for the nerve agent, hydroxocobalamin 5 g for cyanide, and no antidote at all for mustard, where decontamination and supportive burns care are everything. ACEM-primary, globally tagged.

low15 referencesUpdated 26 July 202618 min readVerification in progress

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ACEMFRCEMABEMFRCPCCCFPEMEBEEM

Red flags

  • Decontaminate before the casualty enters the department — removing clothing clears most external contamination and protects staff; never accept a contaminated casualty into the clinical area
  • Profuse vomiting within an hour of a radiation exposure, with a lymphocyte count that halves in 24 hours, marks a supralethal whole-body dose and a poor prognosis
  • A cluster of salivating, fasciculating, bronchorrhoeic casualties with pinpoint pupils is a nerve-agent release — give atropine 2 mg intravenously and repeat until secretions dry, with pralidoxime 30 mg per kilogram
  • Sulfur mustard has no antidote — the entire management is immediate decontamination followed by supportive burns, airway and eye care
  • Soman ages the inhibited enzyme within minutes — pralidoxime must be given early to work at all; delay forfeits reactivation
  • The casualty who is externally decontaminated poses no significant radiation hazard to staff — fear of irradiation must not delay resuscitation
On this page

Related topics

  • The toxidrome approach and the general management of the poisoned patient
  • Cyanide poisoning
  • Carbon monoxide poisoning
  • Burn management in the emergency department
  • Anaemia and blood transfusion in the emergency department
  • Sepsis and septic shock — the emergency department approach
Study tools

Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

ACEMFRCEMABEMFRCPCCCFPEMEBEEM

Red flags

  • Decontaminate before the casualty enters the department — removing clothing clears most external contamination and protects staff; never accept a contaminated casualty into the clinical area
  • Profuse vomiting within an hour of a radiation exposure, with a lymphocyte count that halves in 24 hours, marks a supralethal whole-body dose and a poor prognosis
  • A cluster of salivating, fasciculating, bronchorrhoeic casualties with pinpoint pupils is a nerve-agent release — give atropine 2 mg intravenously and repeat until secretions dry, with pralidoxime 30 mg per kilogram
  • Sulfur mustard has no antidote — the entire management is immediate decontamination followed by supportive burns, airway and eye care
  • Soman ages the inhibited enzyme within minutes — pralidoxime must be given early to work at all; delay forfeits reactivation
  • The casualty who is externally decontaminated poses no significant radiation hazard to staff — fear of irradiation must not delay resuscitation
The one-line answer

Radiation and chemical exposure is a CBRN problem ruled by one command that precedes everything else — decontaminate at the door before the casualty crosses the threshold. Strip the clothing (it clears the majority of the contaminant), shower with warm water and soap, contain the run-off, gown the team. Then resuscitate: atropine 2 mg IV or IM repeated until secretions dry, plus pralidoxime 30 mg per kilogram given early, for the nerve agent; hydroxocobalamin 5 g IV over 15 minutes for cyanide; supportive marrow care with cytokines and isotope-specific decorporation for radiation; and no antidote but rigorous decontamination for sulfur mustard.[1][4]

Meet the patient

Three ambulatory patients stumble through the ambulance bay at once — salivating, streaming tears, pinpoint pupils, wheezing through frothy secretions — and a fourth is carried in apnoeic, fasciculating, cyanosed. They all came from the railway station, and they are still in their street clothes. The registrar reaches for the resus-bay doors.[4]

Stop. The single question that decides the next ten minutes is not "what antidote?" — it is "have they been decontaminated?" A contaminated cluster walked into your department becomes a contaminated department and a contaminated staff. Hold them at the warm zone, strip the clothing, then reach for the atropine.[1]

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References15ShowHide
  1. [1]Waselenko JK, MacVittie TJ, Blakely WF, et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med, 2004.PMID 15197022
  2. [2]Dainiak N, Albanese J. Medical management of acute radiation syndrome. J Radiol Prot, 2022.PMID 35767939
  3. [3]Kearns RD, Hickerson WL, Carter JE. Radiation Injuries. Surg Clin North Am, 2023.PMID 37149389
  4. [4]Hulse EJ, Haslam JD, Emmett SR, Woolley T. Organophosphorus nerve agent poisoning: managing the poisoned patient. Br J Anaesth, 2019.PMID 31248646
  5. [5]Worek F, Thiermann H, Wille T. Organophosphorus compounds and oximes: a critical review. Arch Toxicol, 2020.PMID 32506210
  6. [6]Kehe K, Balszuweit F, Steinritz D, Thiermann H. Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering. Toxicology, 2009.PMID 19651324
  7. [7]Borron SW, Baud FJ, Mégarbane B, et al. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg Med, 2007.PMID 17543660
  8. [8]Reade MC, Davies SR, Morley PT, Dennett J, Jacobs IC; Australian Resuscitation Council. Review article: management of cyanide poisoning. Emerg Med Australas, 2012.PMID 22672162
  9. [9]Vijayaraghavan R. Autoinjector device for rapid administration of drugs and antidotes in emergency situations and in mass casualty management. J Int Med Res, 2020.PMID 32436421
  10. [10]Borron SW, Baud FJ, Barriot P, Imbert M, Bismuth C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg Med, 2007.PMID 17481777
  11. [11]World Health Organization Pocket book of hospital care for children — organophosphate and carbamate poisoning World Health Organization, 2013.Source
  12. [12]Thiermann H, Worek F, Kehe K. Limitations and challenges in treatment of acute chemical warfare agent poisoning. Chem Biol Interact, 2013.PMID 24091052
  13. [13]Buckley NA, Eddleston M, Li Y, Bevan M, Robertson J. Oximes for acute organophosphate pesticide poisoning. Cochrane Database Syst Rev, 2011.PMID 21328273
  14. [14]Marrs TC, Rice P, Vale JA. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicol Rev, 2006.PMID 17288500
  15. [15]Kazzi Z, Buzzell J, Bertelli L, et al. Emergency department management of patients internally contaminated with radioactive material. Emerg Med Clin North Am, 2015.PMID 25455668

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Related topics

  • The toxidrome approach and the general management of the poisoned patient
  • Cyanide poisoning
  • Carbon monoxide poisoning
  • Burn management in the emergency department
  • Anaemia and blood transfusion in the emergency department
  • Sepsis and septic shock — the emergency department approach