EM · Radiation and chemical exposure
Radiation and chemical exposure
Also known as CBRN exposure · Acute radiation syndrome · Nerve agent poisoning · Sulfur mustard exposure · Chemical casualty management
Radiation and chemical exposure — the receiving-hospital side of a CBRN incident. The topic pairs two threats the Fellowship candidate must hold together: ionizing radiation, whose whole-body dose produces the acute radiation syndrome (prodromal nausea and vomiting within hours, marrow suppression and pancytopenia over days to weeks, cutaneous burns), and the chemical warfare and industrial agents — nerve agents that inhibit acetylcholinesterase, the vesicant sulfur mustard, and cyanide. The single most tested decision is decontamination before any casualty crosses the emergency-department threshold: remove the clothing to clear the majority of the contaminant, shower with water and soap, contain the runoff, and protect the staff in personal protective equipment. The antidotes are narrow and must be named with dose and route — atropine 2 mg and pralidoxime 30 mg per kilogram for the nerve agent, hydroxocobalamin 5 g for cyanide, and no antidote at all for mustard, where decontamination and supportive burns care are everything. ACEM-primary, globally tagged.
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Red flags
- Decontaminate before the casualty enters the department — removing clothing clears most external contamination and protects staff; never accept a contaminated casualty into the clinical area
- Profuse vomiting within an hour of a radiation exposure, with a lymphocyte count that halves in 24 hours, marks a supralethal whole-body dose and a poor prognosis
- A cluster of salivating, fasciculating, bronchorrhoeic casualties with pinpoint pupils is a nerve-agent release — give atropine 2 mg intravenously and repeat until secretions dry, with pralidoxime 30 mg per kilogram
- Sulfur mustard has no antidote — the entire management is immediate decontamination followed by supportive burns, airway and eye care
- Soman ages the inhibited enzyme within minutes — pralidoxime must be given early to work at all; delay forfeits reactivation
- The casualty who is externally decontaminated poses no significant radiation hazard to staff — fear of irradiation must not delay resuscitation
Meet the patient
Three ambulatory patients stumble through the ambulance bay at once — salivating, streaming tears, pinpoint pupils, wheezing through frothy secretions — and a fourth is carried in apnoeic, fasciculating, cyanosed. They all came from the railway station, and they are still in their street clothes. The registrar reaches for the resus-bay doors.[4]
Stop. The single question that decides the next ten minutes is not "what antidote?" — it is "have they been decontaminated?" A contaminated cluster walked into your department becomes a contaminated department and a contaminated staff. Hold them at the warm zone, strip the clothing, then reach for the atropine.[1]
References15ShowHide
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- [13]Buckley NA, Eddleston M, Li Y, Bevan M, Robertson J. Oximes for acute organophosphate pesticide poisoning. Cochrane Database Syst Rev, 2011.PMID 21328273
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- [15]Kazzi Z, Buzzell J, Bertelli L, et al. Emergency department management of patients internally contaminated with radioactive material. Emerg Med Clin North Am, 2015.PMID 25455668