EM · Radiation and chemical exposure
Radiation and chemical exposure
Also known as CBRN exposure · Acute radiation syndrome · Nerve agent poisoning · Sulfur mustard exposure · Chemical casualty management
Radiation and chemical exposure — the receiving-hospital side of a CBRN incident. The topic pairs two threats the Fellowship candidate must hold together: ionizing radiation, whose whole-body dose produces the acute radiation syndrome (prodromal nausea and vomiting within hours, marrow suppression and pancytopenia over days to weeks, cutaneous burns), and the chemical warfare and industrial agents — nerve agents that inhibit acetylcholinesterase, the vesicant sulfur mustard, and cyanide. The single most tested decision is decontamination before any casualty crosses the emergency-department threshold: remove the clothing to clear the majority of the contaminant, shower with water and soap, contain the runoff, and protect the staff in personal protective equipment. The antidotes are narrow and must be named with dose and route — atropine 2 mg and pralidoxime 30 mg per kilogram for the nerve agent, hydroxocobalamin 5 g for cyanide, and no antidote at all for mustard, where decontamination and supportive burns care are everything. ACEM-primary, globally tagged.
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8 MCQs with explanations
Target exams
Red flags
Meet the patient
Three ambulatory patients stumble through the ambulance bay at once — salivating, streaming tears, pinpoint pupils, wheezing through frothy secretions — and a fourth is carried in apnoeic, fasciculating, cyanosed. They all came from the railway station, and they are still in their street clothes. The registrar reaches for the resus-bay doors.[4]
Stop. The single question that decides the next ten minutes is not "what antidote?" — it is "have they been decontaminated?" A contaminated cluster walked into your department becomes a contaminated department and a contaminated staff. Hold them at the warm zone, strip the clothing, then reach for the atropine.[1]
You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the Emergency Medicine fellowship atlas.
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- [1]Waselenko JK, MacVittie TJ, Blakely WF, et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group Ann Intern Med, 2004.PMID 15197022
- [2]Dainiak N. Medical management of acute radiation syndrome J Radiol Prot, 2022.PMID 35767939
- [3]Kearns RD, Hickerson WL, Carter JE Radiation Injuries Surg Clin North Am, 2023.PMID 37149389
- [4]Hulse EJ, Haslam JD, Emmett ER, Woolley T. Organophosphorus nerve agent poisoning: managing the poisoned patient Br J Anaesth, 2019.PMID 31248646
- [5]Worek F, Thiermann H, Wille T Organophosphorus compounds and oximes: a critical review Arch Toxicol, 2020.PMID 32506210
- [6]Kehe K, Balszuweit F, Steinritz D, Thiermann H. Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering Toxicology, 2009.PMID 19651324
- [7]Borron SW, Baud FJ, Mégarbane B, et al. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation Am J Emerg Med, 2007.PMID 17543660
- [8]Reade MC, Davies SR, Morley PT, Dennett J, Jacobs IC; Australian Resuscitation Council. Review article: management of cyanide poisoning Emerg Med Australas, 2012.PMID 22672162