EM · Carbon monoxide poisoning
Carbon monoxide poisoning
Also known as CO poisoning · Carboxyhaemoglobinaemia · The silent killer
Carbon monoxide poisoning — the colourless, odourless gas that binds haemoglobin about 240 times more avidly than oxygen, left-shifting the oxyhaemoglobin dissociation curve and producing tissue hypoxia with a falsely normal pulse oximetry. The sources (the faulty heater, the car exhaust, the enclosed fire, the indoor barbecue), the clinical (the headache, the nausea, the confusion, the flu-like illness in multiple household members, the rare cherry-red skin), the diagnosis (the venous carboxyhaemoglobin level), and the management (100 per cent oxygen via a non-rebreather mask; hyperbaric oxygen for the severe — the loss of consciousness, the neurological deficit, the pregnancy, the COHb over 25 per cent). The delayed neurological sequelae — the cognitive impairment and the parkinsonism at 2 to 40 days. ACEM-primary, globally tagged.
Practise this topic
On this page & tools
Your progress
Saved locally on this device.
8 MCQs with explanations
Target exams
Red flags
Meet the patient
A 28-year-old woman who is 26 weeks pregnant is brought in after a syncopal episode at home. She has a frontal headache and nausea; her husband, who arrived with her, has the same headache. They turned on an old unflued gas heater for the first time this winter three hours ago. Her SpO2 reads 99 per cent on the paramedic's monitor. The venous co-oximetry returns a carboxyhaemoglobin of 32 per cent.[2]
Two facts decide her management: the pulse oximetry is lying (COHb absorbs at the same wavelength as oxyhaemoglobin), and she is pregnant (fetal haemoglobin binds CO more avidly, so the fetal COHb runs 10 to 15 per cent above hers). Both the syncope and the pregnancy are absolute indications for hyperbaric oxygen.[1]
You have read the opening of this topic. The complete unit — every section and its primary-source references — is part of the Emergency Medicine fellowship atlas.
References10Show ledgerHide ledger
- [1]Weaver LK, Hopkins RO, Chan KJ, et al. Hyperbaric oxygen for acute carbon monoxide poisoning N Engl J Med, 2002.PMID 12362006
- [2]Weaver LK. Clinical practice. Carbon monoxide poisoning N Engl J Med, 2009.PMID 19297574
- [3]Scheinkestel CD, Bailey M, Myles PS, et al. Hyperbaric or normobaric oxygen for acute carbon monoxide poisoning: a randomised controlled clinical trial Med J Aust, 1999.PMID 10092916
- [4]Hampson NB, Piantadosi CA, Thom SR, Weaver LK. Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning Am J Respir Crit Care Med, 2012.PMID 23087025
- [5]Rose JJ, Wang L, Xu Q, McTiernan CF, et al. Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy Am J Respir Crit Care Med, 2017.PMID 27753502
- [6]Carbon Monoxide Poisoning (Reprinted from the 2023 Hyperbaric Indications Manual 15(th) edition) Undersea Hyperb Med, 2024.PMID 39348519
- [7]MacLennan L, Moiemen N. Management of cyanide toxicity in patients with burns Burns, 2015.PMID 24994676
- [8]Ozgok-Kangal K, et al. Long-term infant outcomes after hyperbaric oxygen treatment for acute carbon monoxide poisoning during pregnancy Diving Hyperb Med, 2021.PMID 34547775
- [9]Bourke M, Schaffer DH. Carbon Monoxide Poisoning StatPearls, 2026.PMID 32491811
- [10]Jin WY, Huang DC, Guo J. Evidence for Hydroxocobalamin in Cyanide Toxicity Caused by Smoke Inhalation: An Updated Systematic Review Emerg Med Int, 2025.PMID 41497958