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EM TopicsBiliary disease

EM · Biliary disease

Biliary disease — biliary colic, acute cholecystitis and ascending cholangitis

Also known as Biliary colic · Acute cholecystitis · Ascending cholangitis · Acute cholangitis · Gallstone disease · Charcot triad

The biliary disease spectrum — biliary colic, the transient cystic duct obstruction with self-limiting post-prandial RUQ pain managed by elective cholecystectomy; acute cholecystitis, the sustained obstruction with RUQ tenderness, fever, a positive Murphy sign, ultrasound wall thickening over 3 mm and pericholecystic fluid, managed with analgesia, antibiotics covering enteric Gram-negatives and anaerobes, and early laparoscopic cholecystectomy; and ascending cholangitis, the obstructed infected biliary tree with Charcot triad and Reynolds pentad, managed with antibiotics, fluid resuscitation and urgent ERCP decompression. ACEM-primary, globally tagged.

high10 referencesUpdated 26 July 202625 min readVerification in progress

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Practise this topic8 MCQs with explanations

Target exams

ACEMFRCEMABEMFRCPCCCFPEMEBEEM

Red flags

  • Right upper quadrant pain with fever and jaundice is ascending cholangitis until proven otherwise — sepsis can develop within hours and demands urgent biliary decompression
  • Pain persisting beyond six hours with fever and a positive Murphy sign is acute cholecystitis, not biliary colic — admit, give antibiotics and arrange early cholecystectomy
  • Hypotension and confusion on a background of RUQ pain, fever and jaundice is Reynolds pentad — severe suppurative cholangitis needing intensive care and ERCP within hours
  • An elderly diabetic with gallstones and crepitus or gas in the gallbladder wall has emphysematous cholecystitis — broad-spectrum antibiotics and emergency cholecystectomy
  • Never attribute epigastric pain to gallstones without an ECG in the older patient — an inferior myocardial infarction is the lethal mimic
On this page

Related topics

  • Acute pancreatitis
  • Acute abdominal pain — the emergency department approach
  • Sepsis and septic shock — the emergency department approach
  • Upper gastrointestinal bleed
  • Acute coronary syndromes (STEMI, NSTEMI and unstable angina)
  • Ectopic pregnancy
  • Point-of-care ultrasound: biliary and renal (and the incidental AAA)
Study tools

Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

ACEMFRCEMABEMFRCPCCCFPEMEBEEM

Red flags

  • Right upper quadrant pain with fever and jaundice is ascending cholangitis until proven otherwise — sepsis can develop within hours and demands urgent biliary decompression
  • Pain persisting beyond six hours with fever and a positive Murphy sign is acute cholecystitis, not biliary colic — admit, give antibiotics and arrange early cholecystectomy
  • Hypotension and confusion on a background of RUQ pain, fever and jaundice is Reynolds pentad — severe suppurative cholangitis needing intensive care and ERCP within hours
  • An elderly diabetic with gallstones and crepitus or gas in the gallbladder wall has emphysematous cholecystitis — broad-spectrum antibiotics and emergency cholecystectomy
  • Never attribute epigastric pain to gallstones without an ECG in the older patient — an inferior myocardial infarction is the lethal mimic
The one-line answer

Biliary disease is one obstruction in three places. A stone that wedges then releases the cystic duct is biliary colic — self-limiting, discharge for elective surgery. A stone that stays is acute cholecystitis — fever, a positive Murphy sign, ultrasound wall thickening over 3 mm, admit for early laparoscopic cholecystectomy within 72 hours. A stone in the common duct plus infection is ascending cholangitis — Charcot triad, Reynolds pentad, sepsis, and the only cure is urgent ERCP, because antibiotics cannot penetrate an obstructed pressurised duct.[1]

Meet the patient

A 74-year-old woman with known gallstones is brought in confused, jaundiced and rigoring, blood pressure 82/48, right upper quadrant pain for a day. The family called it a turn. It is Reynolds pentad — grade III cholangitis — and the phone call that activates ERCP tonight is the intervention that decides whether she leaves hospital.[1]

Hold her at the bedside. Every paragraph below answers the question she asks: where is the stone, is the tree infected, and must the obstruction be relieved in hours rather than days?[1]

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References10ShowHide
  1. [1]Kiriyama S, Kozaka K, Takada T, et al. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos) J Hepatobiliary Pancreat Sci, 2018.PMID 29032610
  2. [2]Yokoe M, Hata J, Takada T, et al. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos) J Hepatobiliary Pancreat Sci, 2018.PMID 29032636
  3. [3]Gomi H, Solomkin JS, Takada T, et al. Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis J Hepatobiliary Pancreat Sci, 2018.PMID 29090866
  4. [4]Gurusamy KS, Davidson C, Gluud C, Davidson BR. Early versus delayed laparoscopic cholecystectomy for people with acute cholecystitis Cochrane Database Syst Rev, 2013.PMID 23813477
  5. [5]Miura F, Okamoto K, Takada T, et al. Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis J Hepatobiliary Pancreat Sci, 2018.PMID 28941329
  6. [6]Evans L, Rhodes A, Alhazzani W, et al. Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021 Crit Care Med, 2021.PMID 34643578
  7. [7]Fugazzola P, Podda M, Tian BW, et al. Clinical update on acute cholecystitis and biliary pancreatitis: between certainties and grey areas EClinicalMedicine, 2024.PMID 39469538
  8. [8]Colli A, Conte D, Valle SD, Sciola V, Fraquelli M. Meta-analysis: nonsteroidal anti-inflammatory drugs in biliary colic Aliment Pharmacol Ther, 2012.PMID 22540869
  9. [9]Akriviadis EA, Hatzigavriel M, Kapnias D, et al. Treatment of biliary colic with diclofenac: a randomized, double-blind, placebo-controlled study Gastroenterology, 1997.PMID 9207282
  10. [10]Sperna Weiland CJ, Busch CBE, et al. Performance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction J Hepatobiliary Pancreat Sci, 2022.PMID 34932265

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Related topics

  • Acute pancreatitis
  • Acute abdominal pain — the emergency department approach
  • Sepsis and septic shock — the emergency department approach
  • Upper gastrointestinal bleed
  • Acute coronary syndromes (STEMI, NSTEMI and unstable angina)
  • Ectopic pregnancy
  • Point-of-care ultrasound: biliary and renal (and the incidental AAA)