EM · Biliary disease
Biliary disease — biliary colic, acute cholecystitis and ascending cholangitis
Also known as Biliary colic · Acute cholecystitis · Ascending cholangitis · Acute cholangitis · Gallstone disease · Charcot triad
The biliary disease spectrum — biliary colic, the transient cystic duct obstruction with self-limiting post-prandial RUQ pain managed by elective cholecystectomy; acute cholecystitis, the sustained obstruction with RUQ tenderness, fever, a positive Murphy sign, ultrasound wall thickening over 3 mm and pericholecystic fluid, managed with analgesia, antibiotics covering enteric Gram-negatives and anaerobes, and early laparoscopic cholecystectomy; and ascending cholangitis, the obstructed infected biliary tree with Charcot triad and Reynolds pentad, managed with antibiotics, fluid resuscitation and urgent ERCP decompression. ACEM-primary, globally tagged.
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Related topics
- Acute pancreatitis
- Acute abdominal pain — the emergency department approach
- Sepsis and septic shock — the emergency department approach
- Upper gastrointestinal bleed
- Acute coronary syndromes (STEMI, NSTEMI and unstable angina)
- Ectopic pregnancy
- Point-of-care ultrasound: biliary and renal (and the incidental AAA)
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Red flags
- Right upper quadrant pain with fever and jaundice is ascending cholangitis until proven otherwise — sepsis can develop within hours and demands urgent biliary decompression
- Pain persisting beyond six hours with fever and a positive Murphy sign is acute cholecystitis, not biliary colic — admit, give antibiotics and arrange early cholecystectomy
- Hypotension and confusion on a background of RUQ pain, fever and jaundice is Reynolds pentad — severe suppurative cholangitis needing intensive care and ERCP within hours
- An elderly diabetic with gallstones and crepitus or gas in the gallbladder wall has emphysematous cholecystitis — broad-spectrum antibiotics and emergency cholecystectomy
- Never attribute epigastric pain to gallstones without an ECG in the older patient — an inferior myocardial infarction is the lethal mimic
Meet the patient
A 74-year-old woman with known gallstones is brought in confused, jaundiced and rigoring, blood pressure 82/48, right upper quadrant pain for a day. The family called it a turn. It is Reynolds pentad — grade III cholangitis — and the phone call that activates ERCP tonight is the intervention that decides whether she leaves hospital.[1]
Hold her at the bedside. Every paragraph below answers the question she asks: where is the stone, is the tree infected, and must the obstruction be relieved in hours rather than days?[1]
References10ShowHide
- [1]Kiriyama S, Kozaka K, Takada T, et al. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos) J Hepatobiliary Pancreat Sci, 2018.PMID 29032610
- [2]Yokoe M, Hata J, Takada T, et al. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos) J Hepatobiliary Pancreat Sci, 2018.PMID 29032636
- [3]Gomi H, Solomkin JS, Takada T, et al. Tokyo Guidelines 2018: antimicrobial therapy for acute cholangitis and cholecystitis J Hepatobiliary Pancreat Sci, 2018.PMID 29090866
- [4]Gurusamy KS, Davidson C, Gluud C, Davidson BR. Early versus delayed laparoscopic cholecystectomy for people with acute cholecystitis Cochrane Database Syst Rev, 2013.PMID 23813477
- [5]Miura F, Okamoto K, Takada T, et al. Tokyo Guidelines 2018: initial management of acute biliary infection and flowchart for acute cholangitis J Hepatobiliary Pancreat Sci, 2018.PMID 28941329
- [6]Evans L, Rhodes A, Alhazzani W, et al. Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021 Crit Care Med, 2021.PMID 34643578
- [7]Fugazzola P, Podda M, Tian BW, et al. Clinical update on acute cholecystitis and biliary pancreatitis: between certainties and grey areas EClinicalMedicine, 2024.PMID 39469538
- [8]Colli A, Conte D, Valle SD, Sciola V, Fraquelli M. Meta-analysis: nonsteroidal anti-inflammatory drugs in biliary colic Aliment Pharmacol Ther, 2012.PMID 22540869
- [9]Akriviadis EA, Hatzigavriel M, Kapnias D, et al. Treatment of biliary colic with diclofenac: a randomized, double-blind, placebo-controlled study Gastroenterology, 1997.PMID 9207282
- [10]Sperna Weiland CJ, Busch CBE, et al. Performance of diagnostic tools for acute cholangitis in patients with suspected biliary obstruction J Hepatobiliary Pancreat Sci, 2022.PMID 34932265