EM · Upper gastrointestinal bleed
Upper gastrointestinal bleed
Also known as Upper GI haemorrhage · Haematemesis and melaena · Acute upper GI bleeding · Variceal bleed · Peptic ulcer bleed
The upper gastrointestinal bleed — haemorrhage proximal to the ligament of Treitz, split into variceal (vasoactive as soon as suspected, prophylactic antibiotics, band ligation, early TIPSS within 72 hours for high-risk cirrhosis) and non-variceal (high-dose PPI infusion, endoscopy within 24 hours, epinephrine plus second method, aspirin continued). Blatchford 1 or less may avoid admission; restrictive transfusion below 7 g/dL; no routine tranexamic acid.
Checked against its sources on 13 Oct 2026
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Red flags
- Split variceal from non-variceal at the door — vasoactive plus antibiotic versus PPI plus combination endoscopy
- Antibiotics in cirrhotic bleed cut mortality, infections and rebleed — ceftriaxone 1 g preferred in advanced disease
- Restrictive transfusion below 7 g/dL — liberal raises portal pressure within 5 days
- Blatchford 1 or less may avoid admission; endoscopy within 24 hours; no routine tranexamic acid
Meet the patient
A 58-year-old man with known alcohol-related cirrhosis is brought to the resuscitation bay having vomited bright red blood, then passed a black tarry stool. He is pale, cool, sweating; blood pressure 86 over 52, pulse 122, capillary refill 4 seconds, and he is drifting towards drowsiness. The nurse asks the one question that decides his next drug: is this a variceal bleed or not?[3]
The answer changes everything that follows. If it is variceal, he gets a vasoactive drug and antibiotics before anyone picks up the scope, transfusion to maintain haemoglobin around 7 to 8 g/dL, and band ligation urgently. If it is non-variceal, the vasoactive is useless and the job is a proton-pump inhibitor, endoscopy within 24 hours, and epinephrine plus a second method. Hold that single fork, and the rest of the station slots into place.[2][3][13]
References17ShowHide
- [1]Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage Lancet, 2000.PMID 11073021
- [2]Villanueva C, Colomo A, Bosch A, et al. Transfusion strategies for acute upper gastrointestinal bleeding N Engl J Med, 2013.PMID 23281973
- [3]García-Pagán JC, Reverter E, Abraldes JG, et al. Acute variceal bleeding Semin Respir Crit Care Med, 2012.PMID 22447260
- [4]Sung JJ, Lau JY, Ching JY, et al. Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial Ann Intern Med, 2010.PMID 19949136
- [5]Rockall TA, Logan RFA, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage Gut, 1996.PMID 8675081
- [6]Saltzman JR, Tabak YP, Hyett BH, Sun X, Travis AC, Johannes RS. A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding Gastrointest Endosc, 2011.PMID 21907980
- [7]García-Pagán JC, Caca K, Bureau C, et al. Early use of TIPS in patients with cirrhosis and variceal bleeding N Engl J Med, 2010.PMID 20573925
- [8]Lau JY, Sung JJ, Lee KK, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers N Engl J Med, 2000.PMID 10922420
- [9]Chavez-Tapia NC, Barrientos-Gutierrez T, Tellez-Avila FI, et al. Antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding Cochrane Database Syst Rev, 2010.PMID 20824832
- [10]Fernández J, Ruiz del Arbol L, Gómez C, et al. Norfloxacin vs ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage Gastroenterology, 2006.PMID 17030175
- [11]HALT-IT Trial Collaborators. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial Lancet, 2020.PMID 32563378
- [12]Stanley AJ, Laine L, Dalton HR, et al. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study BMJ, 2017.PMID 28053181
- [13]Barkun AN, Almadi M, Kuipers EJ, et al. Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group Ann Intern Med, 2019.PMID 31634917
- [14]Vergara M, Bennett C, Calvet X, et al. Epinephrine injection versus epinephrine injection and a second endoscopic method in high-risk bleeding ulcers. The Cochrane database of systematic reviews, 2014.PMID 25308912
- [15]de Groot NL, van Oijen MG, Kessels K, et al. Reassessment of the predictive value of the Forrest classification for peptic ulcer rebleeding and mortality: can classification be simplified? Endoscopy, 2014.PMID 24218308
- [16]Sridharan K, Sivaramakrishnan G Vasoactive Agents for the Management of Variceal Bleeding: A Mixed Treatment Comparison Network Meta-analysis and Trial Sequential Analysis of Randomized Clinical Trials. Drug research, 2019.PMID 30776840
- [17]Lau JYW, Yu Y, Tang RSY, et al. Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding. The New England journal of medicine, 2020.PMID 32242355