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EM TopicsUpper gastrointestinal bleed

EM · Upper gastrointestinal bleed

Upper gastrointestinal bleed

Also known as Upper GI haemorrhage · Haematemesis and melaena · Acute upper GI bleeding · Variceal bleed · Peptic ulcer bleed

The upper gastrointestinal bleed — haemorrhage proximal to the ligament of Treitz, split into variceal (vasoactive as soon as suspected, prophylactic antibiotics, band ligation, early TIPSS within 72 hours for high-risk cirrhosis) and non-variceal (high-dose PPI infusion, endoscopy within 24 hours, epinephrine plus second method, aspirin continued). Blatchford 1 or less may avoid admission; restrictive transfusion below 7 g/dL; no routine tranexamic acid.

high17 referencesUpdated 26 July 202614 min readSource-verified · Oct 2026

Checked against its sources on 13 Oct 2026

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Target exams

ACEMFRCEMABEMFRCPCCCFPEMEBEEM

Red flags

  • Split variceal from non-variceal at the door — vasoactive plus antibiotic versus PPI plus combination endoscopy
  • Antibiotics in cirrhotic bleed cut mortality, infections and rebleed — ceftriaxone 1 g preferred in advanced disease
  • Restrictive transfusion below 7 g/dL — liberal raises portal pressure within 5 days
  • Blatchford 1 or less may avoid admission; endoscopy within 24 hours; no routine tranexamic acid
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Related topics

  • Abdominal aortic aneurysm (ruptured and intact)
  • Acute coronary syndromes (STEMI, NSTEMI and unstable angina)
  • Damage control resuscitation in trauma
  • Fluid resuscitation in the emergency department
  • Acute decompensated heart failure and cardiogenic pulmonary oedema
Study tools

Your progress

Saved on this device.

Target exams

ACEMFRCEMABEMFRCPCCCFPEMEBEEM

Red flags

  • Split variceal from non-variceal at the door — vasoactive plus antibiotic versus PPI plus combination endoscopy
  • Antibiotics in cirrhotic bleed cut mortality, infections and rebleed — ceftriaxone 1 g preferred in advanced disease
  • Restrictive transfusion below 7 g/dL — liberal raises portal pressure within 5 days
  • Blatchford 1 or less may avoid admission; endoscopy within 24 hours; no routine tranexamic acid
The one-line answer

Upper gastrointestinal bleeding is any haemorrhage proximal to the ligament of Treitz, and the first minute of the resuscitation is spent splitting it into the variceal and the non-variceal pathway — the fork that changes every drug you give. Both pathways get ABCDE, two large-bore cannulae, and a restrictive transfusion (threshold 7 g/dL, or below 80 g/L per consensus); the variceal pathway adds a vasoactive drug started as soon as bleeding is suspected plus prophylactic antibiotics, then band ligation and early TIPSS within 72 hours for the high-risk cirrhotic; the non-variceal pathway adds high-dose PPI infusion with endoscopy within 24 hours and epinephrine-plus-second-method for the high-risk ulcer.[2][3][13][14]

Meet the patient

A 58-year-old man with known alcohol-related cirrhosis is brought to the resuscitation bay having vomited bright red blood, then passed a black tarry stool. He is pale, cool, sweating; blood pressure 86 over 52, pulse 122, capillary refill 4 seconds, and he is drifting towards drowsiness. The nurse asks the one question that decides his next drug: is this a variceal bleed or not?[3]

The answer changes everything that follows. If it is variceal, he gets a vasoactive drug and antibiotics before anyone picks up the scope, transfusion to maintain haemoglobin around 7 to 8 g/dL, and band ligation urgently. If it is non-variceal, the vasoactive is useless and the job is a proton-pump inhibitor, endoscopy within 24 hours, and epinephrine plus a second method. Hold that single fork, and the rest of the station slots into place.[2][3][13]

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References17ShowHide
  1. [1]Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage Lancet, 2000.PMID 11073021
  2. [2]Villanueva C, Colomo A, Bosch A, et al. Transfusion strategies for acute upper gastrointestinal bleeding N Engl J Med, 2013.PMID 23281973
  3. [3]García-Pagán JC, Reverter E, Abraldes JG, et al. Acute variceal bleeding Semin Respir Crit Care Med, 2012.PMID 22447260
  4. [4]Sung JJ, Lau JY, Ching JY, et al. Continuation of low-dose aspirin therapy in peptic ulcer bleeding: a randomized trial Ann Intern Med, 2010.PMID 19949136
  5. [5]Rockall TA, Logan RFA, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage Gut, 1996.PMID 8675081
  6. [6]Saltzman JR, Tabak YP, Hyett BH, Sun X, Travis AC, Johannes RS. A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding Gastrointest Endosc, 2011.PMID 21907980
  7. [7]García-Pagán JC, Caca K, Bureau C, et al. Early use of TIPS in patients with cirrhosis and variceal bleeding N Engl J Med, 2010.PMID 20573925
  8. [8]Lau JY, Sung JJ, Lee KK, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers N Engl J Med, 2000.PMID 10922420
  9. [9]Chavez-Tapia NC, Barrientos-Gutierrez T, Tellez-Avila FI, et al. Antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding Cochrane Database Syst Rev, 2010.PMID 20824832
  10. [10]Fernández J, Ruiz del Arbol L, Gómez C, et al. Norfloxacin vs ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage Gastroenterology, 2006.PMID 17030175
  11. [11]HALT-IT Trial Collaborators. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial Lancet, 2020.PMID 32563378
  12. [12]Stanley AJ, Laine L, Dalton HR, et al. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study BMJ, 2017.PMID 28053181
  13. [13]Barkun AN, Almadi M, Kuipers EJ, et al. Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group Ann Intern Med, 2019.PMID 31634917
  14. [14]Vergara M, Bennett C, Calvet X, et al. Epinephrine injection versus epinephrine injection and a second endoscopic method in high-risk bleeding ulcers. The Cochrane database of systematic reviews, 2014.PMID 25308912
  15. [15]de Groot NL, van Oijen MG, Kessels K, et al. Reassessment of the predictive value of the Forrest classification for peptic ulcer rebleeding and mortality: can classification be simplified? Endoscopy, 2014.PMID 24218308
  16. [16]Sridharan K, Sivaramakrishnan G Vasoactive Agents for the Management of Variceal Bleeding: A Mixed Treatment Comparison Network Meta-analysis and Trial Sequential Analysis of Randomized Clinical Trials. Drug research, 2019.PMID 30776840
  17. [17]Lau JYW, Yu Y, Tang RSY, et al. Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding. The New England journal of medicine, 2020.PMID 32242355
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Related topics

  • Abdominal aortic aneurysm (ruptured and intact)
  • Acute coronary syndromes (STEMI, NSTEMI and unstable angina)
  • Damage control resuscitation in trauma
  • Fluid resuscitation in the emergency department
  • Acute decompensated heart failure and cardiogenic pulmonary oedema