EM · Upper airway obstruction
Upper airway obstruction in the emergency department
Also known as Airway obstruction · Stridor · Epiglottitis · Angioedema airway
Upper airway obstruction in the ED — adult and paediatric epiglottitis, croup, Ludwig's angina and deep neck infection, anaphylaxis, the histaminergic versus bradykinin angioedema fork (ACE-inhibitor and hereditary angioedema), choking, inhalation injury, post-extubation stridor, and the DAS can't-intubate-can't-oxygenate scalpel cricothyroidotomy. ACEM-primary, globally tagged.
Checked against its sources on 2 Oct 2026
Practise this topic
On this page
Study tools
Your progress
Saved on this device.
Target exams
Red flags
- In NAP4, 31% of major ED airway events led to death or persistent neurological injury, and failure to use capnography contributed to 74% of such outcomes
- Adult epiglottitis can progress unpredictably and a normal lateral neck radiograph does not exclude it — visualise the epiglottis
- Angioedema without urticaria or itch may be bradykinin-mediated (ACE-inhibitor or hereditary) — antihistamines and steroids are nearly useless; the airway is the priority
- Ludwig's angina can compromise the airway rapidly — call anaesthesia and ENT early and plan flexible intubating endoscopy with a surgical airway prepared
- Can't intubate, can't oxygenate — scalpel cricothyroidotomy is the fastest and most reliable rescue; it requires complete neuromuscular block
Meet the patient
A 54-year-old man is brought to the resuscitation bay at 2am. He is sitting forward, drooling into a bowl, with a muffled voice and a fever. He says swallowing has been getting worse for a day. The registrar reaches for a tongue depressor. In adults, epiglottitis presents most commonly with severe dysphagia in a subacute manner, with drooling, muffled voice and dyspnoea as other features.[1]
The question that decides the next hour is not what is the diagnosis — it is who will secure this airway, where, and what is the plan when it fails? In adults the inflammation involves the surrounding supraglottic structures and disease progression is often unpredictable.[7]
References30ShowHide
- [1]Bridwell RE, Koyfman A, Long B High risk and low prevalence diseases: Adult epiglottitis. The American journal of emergency medicine, 2022.PMID 35489220
- [2]Depetri F, Tedeschi A, Cugno M Angioedema and emergency medicine: From pathophysiology to diagnosis and treatment. European journal of internal medicine, 2019.PMID 30220453
- [3]Frerk C, Mitchell VS, McNarry AF, et al. Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults. British journal of anaesthesia, 2015.PMID 26556848
- [4]Maurer M, Magerl M, Betschel S, et al. The international WAO/EAACI guideline for the management of hereditary angioedema-The 2021 revision and update. Allergy, 2022.PMID 35006617
- [5]Cicardi M, Banerji A, Bracho F, et al. Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema. The New England journal of medicine, 2010.PMID 20818888
- [6]Zuraw BL, Busse PJ, White M, et al. Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema. The New England journal of medicine, 2010.PMID 20818886
- [7]Booth AWG, Pungsornruk K, Llewellyn S, et al. Airway management of adult epiglottitis: a systematic review and meta-analysis. BJA open, 2024.PMID 38230383
- [8]Cook TM, Woodall N, Harper J, et al. Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 2: intensive care and emergency departments. British journal of anaesthesia, 2011.PMID 21447489
- [9]Sinert R, Levy P, Bernstein JA, et al. Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema. The journal of allergy and clinical immunology. In practice, 2017.PMID 28552382
- [10]Rosenbaum S, Wilkerson RG, Winters ME, et al. Clinical Practice Statement: What is the Emergency Department Management of Patients with Angioedema Secondary to an ACE-Inhibitor? The Journal of emergency medicine, 2021.PMID 34006418
- [11]Hahn J, Hoffmann TK, Bock B, et al. Angioedema. Deutsches Arzteblatt international, 2017.PMID 28818177
- [12]Farkas H Management of upper airway edema caused by hereditary angioedema. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2010.PMID 20667122
- [13]Lumry WR, Li HH, Levy RJ, et al. Randomized placebo-controlled trial of the bradykinin B₂ receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2011.PMID 22123383
- [14]Cardona V, Ansotegui IJ, Ebisawa M, et al. World allergy organization anaphylaxis guidance 2020. The World Allergy Organization journal, 2020.PMID 33204386
- [15]Bridwell R, Gottlieb M, Koyfman A, et al. Diagnosis and management of Ludwig's angina: An evidence-based review. The American journal of emergency medicine, 2021.PMID 33383265
- [16]Yang W, Hu L, Wang Z, et al. Deep Neck Infection: A Review of 130 Cases in Southern China. Medicine, 2015.PMID 26166132
- [17]Sanz Sánchez CI, Morales Angulo C Retropharyngeal Abscess. Clinical Review of Twenty-five Years. Acta otorrinolaringologica espanola, 2021.PMID 32487430
- [18]Couper K, Abu Hassan A, Ohri V, et al. Removal of foreign body airway obstruction: A systematic review of interventions. Resuscitation, 2020.PMID 32949674
- [19]Bieliński JR, Huntley R, Dunne CL, et al. Do We Actually Help Choking Children? The Quality of Evidence on the Effectiveness and Safety of First Aid Rescue Manoeuvres: A Narrative Review. Medicina (Kaunas, Lithuania), 2024.PMID 39597012
- [20]White JJ, Cambron JD, Gottlieb M, et al. Evaluation and Management of Airway Foreign Bodies in the Emergency Department Setting. The Journal of emergency medicine, 2023.PMID 36806432
- [21]Badulak JH, Schurr M, Sauaia A, et al. Defining the criteria for intubation of the patient with thermal burns. Burns : journal of the International Society for Burn Injuries, 2018.PMID 29548862
- [22]Gigengack RK, Cleffken BI, Loer SA Advances in airway management and mechanical ventilation in inhalation injury. Current opinion in anaesthesiology, 2020.PMID 33060384
- [23]Gupta K, Mehrotra M, Kumar P, et al. Smoke Inhalation Injury: Etiopathogenesis, Diagnosis, and Management. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2018.PMID 29657376
- [24]Feng IJ, Lin JW, Lai CC, et al. Comparative efficacies of various corticosteroids for preventing postextubation stridor and reintubation: a systematic review and network meta-analysis. Frontiers in medicine, 2023.PMID 37554508
- [25]Smith DK, McDermott AJ, Sullivan JF Croup: Diagnosis and Management. American family physician, 2018.PMID 29763253
- [26]Lee JH, Jung JY, Lee HJ, et al. Efficacy of low-dose nebulized epinephrine as treatment for croup: A randomized, placebo-controlled, double-blind trial. The American journal of emergency medicine, 2019.PMID 30878411
- [27]Moraa I, Sturman N, McGuire TM, et al. Heliox for croup in children. The Cochrane database of systematic reviews, 2021.PMID 34397099
- [28]Mandal A, Kabra SK, Lodha R Upper Airway Obstruction in Children. Indian journal of pediatrics, 2015.PMID 26104110
- [29]Gluck EH, Onorato DJ, Castriotta R Helium-oxygen mixtures in intubated patients with status asthmaticus and respiratory acidosis. Chest, 1990.PMID 2118449
- [30]Ahmad I, El-Boghdadly K, Bhagrath R, et al. Difficult Airway Society guidelines for awake tracheal intubation (ATI) in adults. Anaesthesia, 2020.PMID 31729018