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EM TopicsUpper airway obstruction

EM · Upper airway obstruction

Upper airway obstruction in the emergency department

Also known as Airway obstruction · Stridor · Epiglottitis · Angioedema airway

Upper airway obstruction in the ED — adult and paediatric epiglottitis, croup, Ludwig's angina and deep neck infection, anaphylaxis, the histaminergic versus bradykinin angioedema fork (ACE-inhibitor and hereditary angioedema), choking, inhalation injury, post-extubation stridor, and the DAS can't-intubate-can't-oxygenate scalpel cricothyroidotomy. ACEM-primary, globally tagged.

high30 referencesUpdated 2 Oct 202615 min readSource-verified · Oct 2026

Checked against its sources on 2 Oct 2026

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Target exams

ACEMFRCEMABEMFRCPCCCFPEMEBEEM

Red flags

  • In NAP4, 31% of major ED airway events led to death or persistent neurological injury, and failure to use capnography contributed to 74% of such outcomes
  • Adult epiglottitis can progress unpredictably and a normal lateral neck radiograph does not exclude it — visualise the epiglottis
  • Angioedema without urticaria or itch may be bradykinin-mediated (ACE-inhibitor or hereditary) — antihistamines and steroids are nearly useless; the airway is the priority
  • Ludwig's angina can compromise the airway rapidly — call anaesthesia and ENT early and plan flexible intubating endoscopy with a surgical airway prepared
  • Can't intubate, can't oxygenate — scalpel cricothyroidotomy is the fastest and most reliable rescue; it requires complete neuromuscular block
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Related topics

  • Respiratory failure (type 1 and type 2)
  • Acute severe asthma
Study tools

Your progress

Saved on this device.

Practise this topic8 MCQs with explanations

Target exams

ACEMFRCEMABEMFRCPCCCFPEMEBEEM

Red flags

  • In NAP4, 31% of major ED airway events led to death or persistent neurological injury, and failure to use capnography contributed to 74% of such outcomes
  • Adult epiglottitis can progress unpredictably and a normal lateral neck radiograph does not exclude it — visualise the epiglottis
  • Angioedema without urticaria or itch may be bradykinin-mediated (ACE-inhibitor or hereditary) — antihistamines and steroids are nearly useless; the airway is the priority
  • Ludwig's angina can compromise the airway rapidly — call anaesthesia and ENT early and plan flexible intubating endoscopy with a surgical airway prepared
  • Can't intubate, can't oxygenate — scalpel cricothyroidotomy is the fastest and most reliable rescue; it requires complete neuromuscular block
The one-line answer

Upper airway obstruction is the emergency where the airway plan matters more than the diagnosis. Recognise the threatened airway, keep the patient in the position they have chosen, call anaesthesia and ENT early, and secure the airway with a front-of-neck plan already prepared. Then treat the cause: adult epiglottitis and deep neck infection need antibiotics, source control and ICU observation; anaphylaxis needs intramuscular adrenaline; bradykinin angioedema (hereditary or ACE-inhibitor) does not answer antihistamines or steroids; and when you cannot intubate and cannot oxygenate, the scalpel cricothyroidotomy is the rescue.[8][3][11]

Meet the patient

A 54-year-old man is brought to the resuscitation bay at 2am. He is sitting forward, drooling into a bowl, with a muffled voice and a fever. He says swallowing has been getting worse for a day. The registrar reaches for a tongue depressor. In adults, epiglottitis presents most commonly with severe dysphagia in a subacute manner, with drooling, muffled voice and dyspnoea as other features.[1]

The question that decides the next hour is not what is the diagnosis — it is who will secure this airway, where, and what is the plan when it fails? In adults the inflammation involves the surrounding supraglottic structures and disease progression is often unpredictable.[7]

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References30ShowHide
  1. [1]Bridwell RE, Koyfman A, Long B High risk and low prevalence diseases: Adult epiglottitis. The American journal of emergency medicine, 2022.PMID 35489220
  2. [2]Depetri F, Tedeschi A, Cugno M Angioedema and emergency medicine: From pathophysiology to diagnosis and treatment. European journal of internal medicine, 2019.PMID 30220453
  3. [3]Frerk C, Mitchell VS, McNarry AF, et al. Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults. British journal of anaesthesia, 2015.PMID 26556848
  4. [4]Maurer M, Magerl M, Betschel S, et al. The international WAO/EAACI guideline for the management of hereditary angioedema-The 2021 revision and update. Allergy, 2022.PMID 35006617
  5. [5]Cicardi M, Banerji A, Bracho F, et al. Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema. The New England journal of medicine, 2010.PMID 20818888
  6. [6]Zuraw BL, Busse PJ, White M, et al. Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema. The New England journal of medicine, 2010.PMID 20818886
  7. [7]Booth AWG, Pungsornruk K, Llewellyn S, et al. Airway management of adult epiglottitis: a systematic review and meta-analysis. BJA open, 2024.PMID 38230383
  8. [8]Cook TM, Woodall N, Harper J, et al. Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 2: intensive care and emergency departments. British journal of anaesthesia, 2011.PMID 21447489
  9. [9]Sinert R, Levy P, Bernstein JA, et al. Randomized Trial of Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Upper Airway Angioedema. The journal of allergy and clinical immunology. In practice, 2017.PMID 28552382
  10. [10]Rosenbaum S, Wilkerson RG, Winters ME, et al. Clinical Practice Statement: What is the Emergency Department Management of Patients with Angioedema Secondary to an ACE-Inhibitor? The Journal of emergency medicine, 2021.PMID 34006418
  11. [11]Hahn J, Hoffmann TK, Bock B, et al. Angioedema. Deutsches Arzteblatt international, 2017.PMID 28818177
  12. [12]Farkas H Management of upper airway edema caused by hereditary angioedema. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2010.PMID 20667122
  13. [13]Lumry WR, Li HH, Levy RJ, et al. Randomized placebo-controlled trial of the bradykinin B₂ receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2011.PMID 22123383
  14. [14]Cardona V, Ansotegui IJ, Ebisawa M, et al. World allergy organization anaphylaxis guidance 2020. The World Allergy Organization journal, 2020.PMID 33204386
  15. [15]Bridwell R, Gottlieb M, Koyfman A, et al. Diagnosis and management of Ludwig's angina: An evidence-based review. The American journal of emergency medicine, 2021.PMID 33383265
  16. [16]Yang W, Hu L, Wang Z, et al. Deep Neck Infection: A Review of 130 Cases in Southern China. Medicine, 2015.PMID 26166132
  17. [17]Sanz Sánchez CI, Morales Angulo C Retropharyngeal Abscess. Clinical Review of Twenty-five Years. Acta otorrinolaringologica espanola, 2021.PMID 32487430
  18. [18]Couper K, Abu Hassan A, Ohri V, et al. Removal of foreign body airway obstruction: A systematic review of interventions. Resuscitation, 2020.PMID 32949674
  19. [19]Bieliński JR, Huntley R, Dunne CL, et al. Do We Actually Help Choking Children? The Quality of Evidence on the Effectiveness and Safety of First Aid Rescue Manoeuvres: A Narrative Review. Medicina (Kaunas, Lithuania), 2024.PMID 39597012
  20. [20]White JJ, Cambron JD, Gottlieb M, et al. Evaluation and Management of Airway Foreign Bodies in the Emergency Department Setting. The Journal of emergency medicine, 2023.PMID 36806432
  21. [21]Badulak JH, Schurr M, Sauaia A, et al. Defining the criteria for intubation of the patient with thermal burns. Burns : journal of the International Society for Burn Injuries, 2018.PMID 29548862
  22. [22]Gigengack RK, Cleffken BI, Loer SA Advances in airway management and mechanical ventilation in inhalation injury. Current opinion in anaesthesiology, 2020.PMID 33060384
  23. [23]Gupta K, Mehrotra M, Kumar P, et al. Smoke Inhalation Injury: Etiopathogenesis, Diagnosis, and Management. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2018.PMID 29657376
  24. [24]Feng IJ, Lin JW, Lai CC, et al. Comparative efficacies of various corticosteroids for preventing postextubation stridor and reintubation: a systematic review and network meta-analysis. Frontiers in medicine, 2023.PMID 37554508
  25. [25]Smith DK, McDermott AJ, Sullivan JF Croup: Diagnosis and Management. American family physician, 2018.PMID 29763253
  26. [26]Lee JH, Jung JY, Lee HJ, et al. Efficacy of low-dose nebulized epinephrine as treatment for croup: A randomized, placebo-controlled, double-blind trial. The American journal of emergency medicine, 2019.PMID 30878411
  27. [27]Moraa I, Sturman N, McGuire TM, et al. Heliox for croup in children. The Cochrane database of systematic reviews, 2021.PMID 34397099
  28. [28]Mandal A, Kabra SK, Lodha R Upper Airway Obstruction in Children. Indian journal of pediatrics, 2015.PMID 26104110
  29. [29]Gluck EH, Onorato DJ, Castriotta R Helium-oxygen mixtures in intubated patients with status asthmaticus and respiratory acidosis. Chest, 1990.PMID 2118449
  30. [30]Ahmad I, El-Boghdadly K, Bhagrath R, et al. Difficult Airway Society guidelines for awake tracheal intubation (ATI) in adults. Anaesthesia, 2020.PMID 31729018

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