EM · Environmental emergencies
Altitude illness
Also known as Acute mountain sickness · High altitude cerebral oedema · High altitude pulmonary oedema · AMS HACE HAPE
Altitude illness in the emergency department — acute mountain sickness, HACE and HAPE, ataxia and the Lake Louise score, prevention with slow ascent and acetazolamide, and treatment with descent, oxygen, dexamethasone and pulmonary vasodilators.
Checked against its sources on 24 Oct 2026
Practise this topic
On this page
Study tools
Your progress
Saved on this device.
Target exams
Red flags
- Ataxia, confusion or disturbed consciousness after ascent suggests HACE — descend
- HAPE can progress rapidly with cough, dyspnoea and frothy sputum; descent is mandatory, with immediate descent and/or adequate oxygen as the reliable treatment
- Do not let nifedipine or sildenafil delay descent in HAPE
Meet the patient
A 26-year-old trekker flies to 2800 m and climbs rapidly. Two days later she has a severe headache, nausea and malaise. Her walking is unsteady and she is becoming confused.
Ataxia and confusion change the emergency. HACE is distinguished by disturbed consciousness, psychiatric changes, confusion and ataxia of gait; it often complicates acute mountain sickness or HAPE.[16]
References17ShowHide
- [1]Luks AM, Beidleman BA, Freer L, et al. Wilderness Medical Society Clinical Practice Guidelines for the Prevention, Diagnosis, and Treatment of Acute Altitude Illness: 2024 Update Wilderness Environ Med, 2024.PMID 37833187
- [2]Hackett PH, Roach RC. High-altitude illness N Engl J Med, 2001.PMID 11450659
- [3]Imray C, Booth A, Wright A, et al. Acute altitude illnesses BMJ, 2011.PMID 21844157
- [4]Roach RC, Hackett PH, Oelz O, et al. The 2018 Lake Louise Acute Mountain Sickness Score High Alt Med Biol, 2018.PMID 29583031
- [5]Ferrazzini G, Maggiorini M, Kriemler S, et al. Successful treatment of acute mountain sickness with dexamethasone Br Med J (Clin Res Ed), 1987.PMID 3109663
- [6]Basnyat B, Gertsch JH, Johnson EW, et al. Efficacy of low-dose acetazolamide (125 mg BID) for the prophylaxis of acute mountain sickness: a prospective, double-blind, randomized, placebo-controlled trial High Alt Med Biol, 2003.PMID 12713711
- [7]Bärtsch P, Maggiorini M, Ritter M, et al. Prevention of high-altitude pulmonary edema by nifedipine N Engl J Med, 1991.PMID 1922223
- [8]Maggiorini M, Brunner-La Rocca HP, Peth S, et al. Both tadalafil and dexamethasone may reduce the incidence of high-altitude pulmonary edema: a randomized trial Ann Intern Med, 2006.PMID 17015867
- [9]Maggiorini M. Prevention and treatment of high-altitude pulmonary edema Prog Cardiovasc Dis, 2010.PMID 20417343
- [10]Richalet JP, Gratadour P, Robach P, et al. Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension Am J Respir Crit Care Med, 2005.PMID 15516532
- [11]Honigman B, Theis MK, Koziol-McLain J, et al. Acute mountain sickness in a general tourist population at moderate altitudes. Ann Intern Med, 1993.PMID 8452324
- [12]Hackett PH, Rennie D, Levine HD. The incidence, importance, and prophylaxis of acute mountain sickness. Lancet, 1976.PMID 62991
- [13]Low EV, Avery AJ, Gupta V, Schedlbauer A, Grocott MP. Identifying the lowest effective dose of acetazolamide for the prophylaxis of acute mountain sickness: systematic review and meta-analysis. BMJ, 2012.PMID 23081689
- [14]Stream JO, Grissom CK. Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment. Wilderness Environ Med, 2008.PMID 19099331
- [15]Fiore DC, Hall S, Shoja P Altitude illness: risk factors, prevention, presentation, and treatment. American family physician, 2010.PMID 21121556
- [16]Hackett PH, Roach RC High altitude cerebral edema. High altitude medicine & biology, 2004.PMID 15265335
- [17]Bird BA, Wright AD, Wilson MH, et al. High altitude ataxia--its assessment and relevance. Wilderness & environmental medicine, 2011.PMID 21664562