Anaes SAQs · Neuromuscular blockade & reversal
Sugammadex reversal of neuromuscular blockade
Short-answer question on sugammadex mechanism, dosing, adverse effects and contraindications.
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Prompt
Describe the mechanism of action of sugammadex, its depth-based dosing, and its principal adverse effects and contraindications.
Question
Describe the mechanism of action of sugammadex, its depth-based dosing, and its principal adverse effects and contraindications.
[3]References14ShowHide
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- [2]Lee S, et al. Successful rescue for anaphylactic shock due to sugammadex using extracorporeal cardiopulmonary resuscitation. Perfusion, 2026.PMID 42087621
- [3]Habib R, et al. Sugammadex-Associated Delayed Laryngeal and Upper Airway Edema: A Novel Adverse Effect. J Investig Med High Impact Case Rep, 2026.PMID 42113672
- [4]Akça Ş, Akın AK, Özdemir F, et al. Effects of Sugammadex and Neostigmine on Maternal Steroid and Lactation-Related Hormone Levels During Cesarean Section: A Randomized Clinical Trial. J Clin Pract Res, 2025.PMID 42305259
- [5]Leslie K, et al. Sugammadex versus neostigmine for reversal of neuromuscular blockade and postoperative pulmonary complications (SNaPP): an international, randomised, controlled, phase 4 trial. Lancet Respir Med, 2026.PMID 42263720
- [6]Tsai YF, et al. Sugammadex vs. neostigmine and the risk of postoperative pulmonary complications after upper gastrointestinal endoscopic procedures: a propensity score matched analysis of 15,730 patients. Anaesthesia, 2026.PMID 42317106
- [7]Felix F, et al. Recurarization in the Post-anesthesia Care Unit One Hour After Sugammadex Administration: A Case Report. Cureus, 2026.PMID 42306367
- [8]Krönauer T, Girrbach F, Simon P, et al. [Muscle relaxation and neuromuscular monitoring : Current findings and recommendations for the clinical practice]. Die Anaesthesiologie, 2026.PMID 42334564
- [9]Rex C, et al. Sugammadex: a selective relaxant-binding agent providing rapid reversal. Curr Opin Anaesthesiol, 2010.PMID 20489603
- [10]Hristovska AM, et al. Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults. Cochrane Database Syst Rev, 2017.PMID 28806470
- [11]Chambers D, et al. Sugammadex for reversal of neuromuscular block after rapid sequence intubation: a systematic review and economic assessment. Br J Anaesth, 2010.PMID 20937718
- [12]Panhuizen IF, et al. Efficacy, safety and pharmacokinetics of sugammadex 4 mg kg-1 for reversal of deep neuromuscular blockade in patients with severe renal impairment. Br J Anaesth, 2015.PMID 25829395
- [13]Elkhateb R, et al. Neuromuscular Blockade and Antagonism in Patients with Renal Impairment: A Multicenter Retrospective Cross-sectional Study. Anesthesiology, 2025.PMID 39928534
- [14]Devoy T, et al. A prospective observational study of the effects of sugammadex on peri-operative oestrogen and progesterone levels in women who take hormonal contraception. Anaesthesia, 2023.PMID 36336462