Anaes SAQs · Neuromuscular blockade & reversal
The physiology of the neuromuscular junction
The Primary (basic-science) NMB question — the NMJ, acetylcholine release, the nicotinic receptor, acetylcholinesterase, and the two mechanisms of block (persistent depolarisation vs competitive antagonism). Anchored to the Naguib monitoring consensus for the receptor/monitoring link.
On this page
Study tools
Target exams
ANZCAFRCAABAEDAIC
Prompt
Outline the physiology of the neuromuscular junction. Describe the sequence from nerve action potential to muscle contraction, and explain how a depolarising and a non-depolarising neuromuscular blocker each abolishes transmission.
Question
Outline the physiology of the neuromuscular junction. Describe the sequence from nerve action potential to muscle contraction, and explain how a depolarising and a non-depolarising neuromuscular blocker each abolishes transmission.
References3ShowHide
- [5]Naguib M, Brull SJ, Kopman AF, Hunter JM, et al. Consensus Statement on Perioperative Use of Neuromuscular Monitoring. Anesthesia & Analgesia, 2018.PMID 29200077
- [1]Gijsenbergh F, Ramael S, Houwing N, van Iersel T. First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide. Anesthesiology, 2005.PMID 16192761
- [6]Bersten AD, Soni N (eds) Oh's Intensive Care Manual. 8th edition, Elsevier, 2018.