Anaes SAQs · Neuromuscular blockade & reversal
Succinylcholine — pharmacology, uses and adverse effects
The succinylcholine SAQ — the depolarising mechanism, the unmatched 30-60s onset, the short duration (plasma cholinesterase), and the examined list of adverse effects (hyperkalaemia in upregulated muscle, MH trigger, bradycardia, myalgia, anaphylaxis, prolonged block). Anchored to the Tran rocuronium-vs-sux Cochrane and the Mertes hypersensitivity epidemiology.
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ANZCAFRCAABAEDAIC
Prompt
Outline the pharmacology of succinylcholine. Include its mechanism, onset and duration, its principal uses, and its important adverse effects and contraindications.
Question
Outline the pharmacology of succinylcholine. Include its mechanism, onset and duration, its principal uses, and its important adverse effects and contraindications.
References3ShowHide
- [8]Tran DT, Newton EK, Mount VA, Lee JS, et al. Rocuronium versus succinylcholine for rapid sequence induction intubation. Cochrane Database of Systematic Reviews, 2015.PMID 26512948
- [7]Mertes PM, Ebo DG, Garcez T, Rose M, et al. Comparative epidemiology of suspected perioperative hypersensitivity reactions. British Journal of Anaesthesia, 2019.PMID 30916015
- [9]Bersten AD, Soni N (eds) Oh's Intensive Care Manual. 8th edition, Elsevier, 2018.