Anaes SAQs · Applied cardiovascular & respiratory physiology
Hepatic physiology and drug metabolism
Primary — dual blood supply (portal vein 75 percent, hepatic artery 25 percent); Phase I (CYP450 oxidation) and Phase II (conjugation); first-pass metabolism; extraction ratio (high flow-limited, low capacity-limited); enzyme induction and inhibition; liver dysfunction (INR, albumin, drug accumulation); preferred drugs in liver disease.
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ANZCAFRCAABAEDAIC
Prompt
Describe the hepatic blood supply and the two phases of drug metabolism. Explain the concept of the hepatic extraction ratio and its relevance to drug dosing in liver disease.
Question
Describe the hepatic blood supply and the two phases of drug metabolism. Explain the concept of the hepatic extraction ratio and its relevance to drug dosing in liver disease.[2]
References5ShowHide
- [1]Scudamore O, et al. The Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of Zongertinib in Healthy Male Volunteers. Pharmacotherapy, 2026.PMID 42324472
- [3]Madani R, et al. Dual-vessel hepatic infarction. Front Surg, 2026.PMID 42305804
- [5]Monet C, et al. Impact of Molecular Adsorbent Recirculating System Therapy on Piperacillin Concentration in Critically Ill Patients: An Observational Cohort Study. Crit Care Med, 2026.PMID 42301229
- [2]Zanger UM, Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther, 2013.PMID 23333322
- [6]Mróz A, Mazerska Z. Glucuronidation of antitumour therapeutics--detoxification, mechanism of resistance or prodrug formation? Postepy Hig Med Dosw, 2015.PMID 27259218