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Phys Topicsgastrointestinal

Phys · gastrointestinal

Oesophageal Disorders

Also known as GORD · GERD · reflux · heartburn · Barrett's oesophagus · Barrett's esophagus · eosinophilic oesophagitis · EoE · achalasia · oesophageal cancer · dysphagia · odynophagia · Schatzki ring · Boerhaave syndrome · Zenker diverticulum

Consultant-physician-depth guide to oesophageal disorders — the dysphagia discrimination framework, GORD and the refractory-reflux workup, Barrett's surveillance and endoscopic eradication, eosinophilic oesophagitis from PPI-first to dupilumab, achalasia subtypes and subtype-matched treatment, oesophageal cancer staging and neoadjuvant therapy, and the oesophageal emergencies — structured for FRACP DWE and DCE preparation.

high25 referencesUpdated 26 July 202617 min readVerification in progress

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FRACP DWEFRACP DCEMRCP Part 2ABIM Internal Medicine

Red flags

  • Progressive dysphagia to solids with weight loss in an older patient — malignancy until endoscopy proves otherwise
  • Food bolus obstruction — urgent endoscopy; afterwards biopsy the oesophagus because EoE is the commonest cause in young adults
  • Odynophagia in an immunocompromised host — infective oesophagitis (candida, CMV, HSV) until proven otherwise
  • Forceful vomiting then severe chest pain with subcutaneous emphysema — Boerhaave syndrome; contrast CT now, theatre within hours
  • Regurgitation of undigested food with recurrent pneumonia — achalasia with aspiration or a pharyngeal pouch
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Target exams

FRACP DWEFRACP DCEMRCP Part 2ABIM Internal Medicine

Red flags

  • Progressive dysphagia to solids with weight loss in an older patient — malignancy until endoscopy proves otherwise
  • Food bolus obstruction — urgent endoscopy; afterwards biopsy the oesophagus because EoE is the commonest cause in young adults
  • Odynophagia in an immunocompromised host — infective oesophagitis (candida, CMV, HSV) until proven otherwise
  • Forceful vomiting then severe chest pain with subcutaneous emphysema — Boerhaave syndrome; contrast CT now, theatre within hours
  • Regurgitation of undigested food with recurrent pneumonia — achalasia with aspiration or a pharyngeal pouch

Oesophageal Disorders

The answer first

Almost everything an examiner can ask about the oesophagus hangs off one history question: what does the patient struggle to swallow, and how has it evolved? Dysphagia that begins with solids and progresses is a mechanical narrowing (stricture, ring, cancer) until proven otherwise; dysphagia that involves liquids from the very first day is a motility disorder (achalasia, spasm) until proven otherwise. Get that distinction out loud in the first thirty seconds and the rest of the work-up — endoscopy, barium swallow, manometry — falls into place behind it [1].

Three further rules carry the DWE and the long case [2]:

  1. Alarm features change the first test. Progressive dysphagia, weight loss, anaemia, haematemesis or persistent vomiting means endoscopy now — not a PPI trial and a review in eight weeks [1].
  2. Prove the disease before you escalate the treatment. Refractory "reflux" deserves objective pH-impedance testing off PPI before anyone reaches for a fundoplication; suspected achalasia deserves manometry before anyone dilates anything [2] [19].
  3. Dysplasia ends surveillance. A Barrett's patient with confirmed dysplasia has crossed from watching to treating — endoscopic eradication with resection of visible lesions plus radiofrequency ablation is the standard, backed by randomised trials [5] [8] [9].
The 30-second registrar answer

"Dysphagia splits on two axes: solids versus solids-and-liquids, and progressive versus intermittent. Solids-only and progressive is mechanical — scope it. Liquids from day one is motility — manometry. Intermittent solids-only in an adult is usually a Schatzki ring; a food bolus in a young atopic man is eosinophilic oesophagitis; and heartburn with alarm features is never trialled on PPIs — it is scoped." [1]


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References25ShowHide
  1. [1]Liu LWC, Andrews CN, Armstrong D, et al. Clinical Practice Guidelines for the Assessment of Uninvestigated Esophageal Dysphagia J Can Assoc Gastroenterol, 2018.PMID 31294391
  2. [2]Katz PO, Dunbar KB, Schnoll-Sussman FH, et al. ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease Am J Gastroenterol, 2022.PMID 34807007
  3. [3]Kaltenbach T, Crockett S, Gerson LB. Are lifestyle measures effective in patients with gastroesophageal reflux disease? An evidence-based approach Arch Intern Med, 2006.PMID 16682569
  4. [4]Galmiche JP, Hatlebakk J, Attwood S, et al. Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD: the LOTUS randomized clinical trial JAMA, 2011.PMID 21586712
  5. [5]Shaheen NJ, Falk GW, Iyer PG, et al. Diagnosis and Management of Barrett's Esophagus: An Updated ACG Guideline Am J Gastroenterol, 2022.PMID 35354777
  6. [6]Sharma P, Dent J, Armstrong D, et al. The development and validation of an endoscopic grading system for Barrett's esophagus: the Prague C & M criteria Gastroenterology, 2006.PMID 17101315
  7. [7]Hvid-Jensen F, Pedersen L, Drewes AM, et al. Incidence of adenocarcinoma among patients with Barrett's esophagus N Engl J Med, 2011.PMID 21995385
  8. [8]Shaheen NJ, Sharma P, Overholt BF, et al. Radiofrequency ablation in Barrett's esophagus with dysplasia N Engl J Med, 2009.PMID 19474425
  9. [9]Phoa KN, van Vilsteren FG, Weusten BL, et al. Radiofrequency ablation vs endoscopic surveillance for patients with Barrett esophagus and low-grade dysplasia: a randomized clinical trial JAMA, 2014.PMID 24668102
  10. [10]Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults J Allergy Clin Immunol, 2011.PMID 21477849
  11. [11]Lucendo AJ, Arias Á, Molina-Infante J. Efficacy of Proton Pump Inhibitor Drugs for Inducing Clinical and Histologic Remission in Patients With Symptomatic Esophageal Eosinophilia: A Systematic Review and Meta-Analysis Clin Gastroenterol Hepatol, 2016.PMID 26247167
  12. [12]Kagalwalla AF, Sentongo TA, Ritz S, et al. Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis Clin Gastroenterol Hepatol, 2006.PMID 16860614
  13. [13]Lucendo AJ, Miehlke S, Schlag C, et al. Efficacy of Budesonide Orodispersible Tablets as Induction Therapy for Eosinophilic Esophagitis in a Randomized Placebo-Controlled Trial Gastroenterology, 2019.PMID 30922997
  14. [14]Dellon ES, Rothenberg ME, Collins MH, et al. Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis N Engl J Med, 2022.PMID 36546624
  15. [15]Yadlapati R, Kahrilas PJ, Fox MR, et al. Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0(©) Neurogastroenterol Motil, 2021.PMID 33373111
  16. [16]Boeckxstaens GE, Annese V, des Varannes SB, et al. Pneumatic dilation versus laparoscopic Heller's myotomy for idiopathic achalasia N Engl J Med, 2011.PMID 21561346
  17. [17]Moonen A, Annese V, Belmans A, et al. Long-term results of the European achalasia trial: a multicentre randomised controlled trial comparing pneumatic dilation versus laparoscopic Heller myotomy Gut, 2016.PMID 26614104
  18. [18]Werner YB, Hakanson B, Martinek J, et al. Endoscopic or Surgical Myotomy in Patients with Idiopathic Achalasia N Engl J Med, 2019.PMID 31800987
  19. [19]Vaezi MF, Pandolfino JE, Yadlapati RH, et al. ACG Clinical Guidelines: Diagnosis and Management of Achalasia Am J Gastroenterol, 2020.PMID 32773454
  20. [20]Eckardt VF, Aignherr C, Bernhard G. Predictors of outcome in patients with achalasia treated by pneumatic dilation Gastroenterology, 1992.PMID 1451966
  21. [21]van Hagen P, Hulshof MC, van Lanschot JJ, et al. Preoperative chemoradiotherapy for esophageal or junctional cancer N Engl J Med, 2012.PMID 22646630
  22. [22]Shapiro J, van Lanschot JJB, Hulshof MCCM, et al. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial Lancet Oncol, 2015.PMID 26254683
  23. [23]Al-Batran SE, Homann N, Pauligk C, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial Lancet, 2019.PMID 30982686
  24. [24]Chirica M, Kelly MD, Siboni S, et al. Esophageal emergencies: WSES guidelines World J Emerg Surg, 2019.PMID 31164915
  25. [25]Kikendall JW. Pill esophagitis J Clin Gastroenterol, 1999.PMID 10372925

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