Paeds Vivas · neurology-neurodisability-and-neuromuscular
Non-epileptic events and functional seizures — branching viva
Branching viva across three young people with non-epileptic events: a thirteen-year-old whose bizarre brief nocturnal attacks could be functional or frontal-lobe epilepsy, testing the diagnostic trap and the place of video-electroencephalogram; a fifteen-year-old with treatment-resistant spells on two antiseizure drugs, testing the positive diagnosis and the pathway of explanation, drug withdrawal and cognitive behavioural therapy; and a sixteen-year-old in a prolonged emergency-department flurry, testing the safe management of status non-epilepticus and the safeguarding history.
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Stem 1 — Thirteen-year-old with bizarre brief nocturnal attacks (5 minutes)
A thirteen-year-old boy is referred for nocturnal attacks in which he suddenly sits up, thrashes his limbs for thirty to sixty seconds with his eyes open, and then returns to sleep. The events cluster, occurring several times a night, and began after he started a new school. His interictal electroencephalogram is normal. [1]
Branch A (examiner): What are the two leading diagnoses, and which semiological features would you use to separate a functional event from frontal-lobe epilepsy? [1]
Branch B (examiner): The examiner points out that frontal-lobe epilepsy can show a normal scalp electroencephalogram. How do you resolve this, and what further investigation would you arrange? [8]
Branch C (examiner): The attacks are captured on video-electroencephalogram and the ictal recording is normal. Explain how you would deliver the diagnosis and outline the management. [3] [10]
References12ShowHide
- [1]Leibetseder A; Eisermann M; LaFrance WC Jr; et al How to distinguish seizures from non-epileptic manifestations Epileptic Disord, 2020.PMID 33399092
- [2]Doss JL; Robinson JO; et al Psychogenic non-epileptic seizures in youth: Individual and family psychiatric characteristics Front Psychiatry, 2022.PMID 36590633
- [3]Gasparini S; Beghi E; Ferlazzo E; et al Management of psychogenic non-epileptic seizures: a multidisciplinary approach Eur J Neurol, 2019.PMID 30300463
- [4]Espay AJ; Aybek S; Carson A; et al Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders JAMA Neurol, 2018.PMID 29868890
- [5]Lopez MR; LaFrance WC Jr Treatment of Psychogenic Nonepileptic Seizures Curr Neurol Neurosci Rep, 2022.PMID 35674871
- [6]Hallett M; Aybek S; Dworetzky BA; et al Functional neurological disorder: new subtypes and shared mechanisms Lancet Neurol, 2022.PMID 35430029
- [7]Patel H; Blake H; Dunn D Psychogenic Nonepileptic Seizures in Children and Adolescents Indian Pediatr, 2021.PMID 33713062
- [8]Albert DVF; Voeller K; et al Psychogenic Nonepileptic Seizures in Children and Adolescents Semin Pediatr Neurol, 2022.PMID 35450667
- [9]LaFrance WC Jr; Baird GL; Barry JJ; et al Multicenter pilot treatment trial for psychogenic nonepileptic seizures: a randomized clinical trial JAMA Psychiatry, 2014.PMID 24989152
- [10]Goldstein LH; Robinson EJ; Mellers JDC; et al Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial Lancet Psychiatry, 2020.PMID 32445688
- [11]Spiegel D; Lewis-Fernandez R; Lanius R; et al Dissociative disorders in DSM-5 Annu Rev Clin Psychol, 2013.PMID 23394228
- [12]Hamed SA; Attiah FA; Fawzy M Psychogenic nonepileptic seizures in adults with epilepsy: a tertiary hospital-based study Int J Neurosci, 2020.PMID 31771384