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Paeds Vivasneurology-neurodisability-and-neuromuscular

Paeds Vivas · neurology-neurodisability-and-neuromuscular

Paediatric stroke and cerebral sinovenous thrombosis: Viva

Branching clinical structured oral on paediatric stroke and cerebral sinovenous thrombosis covering the classification, the arteriopathy cause search, the imaging pathway, the antithrombotic therapy for arterial ischaemic stroke, the anticoagulation for cerebral sinovenous thrombosis, and the Thrombolysis in Pediatric Stroke trial.

branching clinical structured oral3 min readVerification in progress

Target exams

RACP DWERACP DCEMRCPCH Clinical
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Target exams

RACP DWERACP DCEMRCPCH Clinical
Prompt
A 6-year-old girl is brought to the emergency department with a one-day history of progressive headache, vomiting, and new-onset seizures. She was discharged from hospital three days ago after treatment for a severe ear infection. On examination she is drowsy, she has papilloedema on fundoscopy, and she has a mild left-sided weakness. Her bedside glucose is normal. The examiner asks how you classify paediatric stroke, how you would investigate and manage this girl, why anticoagulation is given for cerebral sinovenous thrombosis even with bleeding, and how you would run the arteriopathy workup if the scenario were an arterial ischaemic stroke instead.

Branch 1: Classification and the bedside approach

The candidate should classify paediatric stroke into arterial ischaemic stroke, cerebral sinovenous thrombosis, and haemorrhagic stroke, and state that the division matters because each form carries a distinct cause, imaging target, and treatment. A strong candidate states that this girl, with headache, papilloedema, seizures, and a recent ear infection, has the classic presentation of cerebral sinovenous thrombosis, and that the ear infection likely spread to the adjacent dural sinuses to produce a transverse or sigmoid sinus thrombosis. [2]

If the examiner presses on the bedside approach, the candidate should state that the first move is to assess and support the airway, breathing, and circulation, to check the bedside glucose, and to establish the time of onset. The candidate should state that the stroke alert is activated, that the paediatric neurology and radiology teams are notified, and that the urgent imaging request is for an MRI brain with diffusion-weighted imaging, MRA, and MRV, because the MRV is the sequence that will reveal the venous sinus thrombosis that a plain MRI or CT would miss. [9]

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References4ShowHide
  1. [2]Ferriero DM, Fullerton HJ, Bernard TJ, et al Management of Stroke in Neonates and Children: A Scientific Statement From the American Heart Association/American Stroke Association. Stroke, 2019.PMID 30686119
  2. [9]Mandel-Shorer N, Sabapathy CA, Krishnan P, et al. Cerebral Sinovenous Thrombosis in Infants and Children: A Practical Approach to Management. Semin Pediatr Neurol, 2022.PMID 36456034
  3. [1]deVeber G, Andrew M, Adams C, et al Cerebral sinovenous thrombosis in children. N Engl J Med, 2001.PMID 11496852
  4. [5]Amlie-Lefond C, deVeber G, Chan AK, et al Thrombolysis in acute childhood stroke: design and challenges of the thrombolysis in pediatric stroke clinical trial. Neuroepidemiology, 2009.PMID 19223687
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