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Paeds Topicsrespiratory-sleep-and-airway

Paeds · respiratory-sleep-and-airway

Laryngomalacia, tracheomalacia and vocal-cord dysfunction

Also known as Laryngomalacia · Congenital stridor · Tracheomalacia · Tracheobronchomalacia · Vocal-cord dysfunction · Paradoxical vocal-fold motion · Inducible laryngeal obstruction · Exercise-induced laryngeal obstruction

Fellowship guide to the three dynamic paediatric airway-collapse disorders: laryngomalacia as the commonest cause of infant stridor, tracheomalacia as the barking cough and salbutamol-unresponsive wheeze that mimics asthma, and vocal-cord dysfunction (inducible laryngeal obstruction) as the exertional inspiratory stridor of adolescents. Covers localising the noise by respiratory phase, awake flexible laryngoscopy versus dynamic bronchoscopy, when the child needs only reassurance versus supraglottoplasty or airway surgery, the salbutamol and steroid escalation traps, and speech-therapy breathing retraining.

high12 referencesUpdated 15 July 202616 min readVerification in progress

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Target exams

RACP DWERACP DCEMRCPCH TheoryMRCPCH ClinicalABP General PediatricsRCPSC Pediatrics

Red flags

  • Apnoea, cyanosis or a 'dying spell' in an infant with stridor signalling severe laryngomalacia
  • Faltering growth or feeding failure in a child with dynamic airway collapse
  • Stridor present from birth or in the first hours of life, which points away from simple laryngomalacia to a fixed lesion
  • Biphasic stridor, a weak or abnormal cry, or stridor that fails to improve, suggesting a second airway lesion
  • A barking, seal-like cough with wheeze that does not respond to bronchodilators, suggesting tracheomalacia rather than asthma
  • Sudden exertional inspiratory stridor with throat tightness in an adolescent labelled as refractory asthma
  • An acute cyanotic collapse (reflex apnoea) during a feed or a viral illness in a child with tracheomalacia

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescent

Care settings

preventive-medical-homecommunity-schooloutpatientwarded-acutepicutelehealth

Clinical exam formats

racp-dce-long-caseracp-dce-short-casemrcpch-short-clinicalmrcpch-history-managementmrcpch-communicationrcpsc-structured-oral

Board mappings

  • Recognises laryngomalacia as the commonest cause of infant stridor and describes its natural history
  • Localises a noisy airway by the phase of the respiratory cycle
  • Identifies the red flags that separate benign from severe dynamic airway collapse
  • Justifies awake flexible laryngoscopy versus dynamic bronchoscopy in the noisy-airway work-up
  • Differentiates tracheomalacia from asthma and explains the salbutamol trap
  • Plans surgical escalation to supraglottoplasty or airway surgery for severe disease
  • Assessment of the infant with stridor and feeding difficulty
  • Recognition of severe laryngomalacia needing intervention
  • The child with a barking cough and wheeze unresponsive to bronchodilator
  • Bedside assessment of the stridulous infant and the exercising adolescent
  • Communicating the benign natural history of laryngomalacia to anxious parents
  • Counselling a teenager and family on vocal-cord dysfunction and breathing retraining
  • Level 1: Recognises stridor and the red flags for urgent airway referral
  • Level 2: Diagnosis and initial management of laryngomalacia and tracheomalacia
  • Level 3: Coordinates airway surgery, ventilatory support and multidisciplinary care
  • Causes of stridor by age and the localising value of respiratory phase
  • Pathophysiology of dynamic airway collapse and vocal-cord dysfunction
  • Indications for supraglottoplasty, aortopexy and speech therapy
  • History and examination of the infant with noisy breathing
  • Structured assessment of the adolescent with exertional breathlessness
  • Communication of a benign diagnosis and its safety-net
  • Diagnosis of laryngomalacia and the natural history of resolution
  • Distinguishing tracheomalacia and vocal-cord dysfunction from asthma
  • Recognition of severe airway collapse requiring intervention
  • Evaluation of stridor and dynamic airway obstruction in children
  • Risk-stratified management from reassurance to airway surgery
  • Recognition and initial stabilisation of the acute airway collapse
  • Assessment of the Canadian child with congenital stridor
  • Management pathways for severe laryngomalacia and tracheomalacia
  • Multidisciplinary care of vocal-cord dysfunction and EILO in adolescents
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Target exams

RACP DWERACP DCEMRCPCH TheoryMRCPCH ClinicalABP General PediatricsRCPSC Pediatrics

Red flags

  • Apnoea, cyanosis or a 'dying spell' in an infant with stridor signalling severe laryngomalacia
  • Faltering growth or feeding failure in a child with dynamic airway collapse
  • Stridor present from birth or in the first hours of life, which points away from simple laryngomalacia to a fixed lesion
  • Biphasic stridor, a weak or abnormal cry, or stridor that fails to improve, suggesting a second airway lesion
  • A barking, seal-like cough with wheeze that does not respond to bronchodilators, suggesting tracheomalacia rather than asthma
  • Sudden exertional inspiratory stridor with throat tightness in an adolescent labelled as refractory asthma
  • An acute cyanotic collapse (reflex apnoea) during a feed or a viral illness in a child with tracheomalacia

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescent

Care settings

preventive-medical-homecommunity-schooloutpatientwarded-acutepicutelehealth

Clinical exam formats

racp-dce-long-caseracp-dce-short-casemrcpch-short-clinicalmrcpch-history-managementmrcpch-communicationrcpsc-structured-oral

Board mappings

  • Recognises laryngomalacia as the commonest cause of infant stridor and describes its natural history
  • Localises a noisy airway by the phase of the respiratory cycle
  • Identifies the red flags that separate benign from severe dynamic airway collapse
  • Justifies awake flexible laryngoscopy versus dynamic bronchoscopy in the noisy-airway work-up
  • Differentiates tracheomalacia from asthma and explains the salbutamol trap
  • Plans surgical escalation to supraglottoplasty or airway surgery for severe disease
  • Assessment of the infant with stridor and feeding difficulty
  • Recognition of severe laryngomalacia needing intervention
  • The child with a barking cough and wheeze unresponsive to bronchodilator
  • Bedside assessment of the stridulous infant and the exercising adolescent
  • Communicating the benign natural history of laryngomalacia to anxious parents
  • Counselling a teenager and family on vocal-cord dysfunction and breathing retraining
  • Level 1: Recognises stridor and the red flags for urgent airway referral
  • Level 2: Diagnosis and initial management of laryngomalacia and tracheomalacia
  • Level 3: Coordinates airway surgery, ventilatory support and multidisciplinary care
  • Causes of stridor by age and the localising value of respiratory phase
  • Pathophysiology of dynamic airway collapse and vocal-cord dysfunction
  • Indications for supraglottoplasty, aortopexy and speech therapy
  • History and examination of the infant with noisy breathing
  • Structured assessment of the adolescent with exertional breathlessness
  • Communication of a benign diagnosis and its safety-net
  • Diagnosis of laryngomalacia and the natural history of resolution
  • Distinguishing tracheomalacia and vocal-cord dysfunction from asthma
  • Recognition of severe airway collapse requiring intervention
  • Evaluation of stridor and dynamic airway obstruction in children
  • Risk-stratified management from reassurance to airway surgery
  • Recognition and initial stabilisation of the acute airway collapse
  • Assessment of the Canadian child with congenital stridor
  • Management pathways for severe laryngomalacia and tracheomalacia
  • Multidisciplinary care of vocal-cord dysfunction and EILO in adolescents

Overview & Definition

Three disorders sit together in this topic because they share one idea: an airway that is structurally open at rest but gives way when the pressure across its wall exceeds its own stiffness. Laryngomalacia is the floppy supraglottis of the infant, tracheomalacia is the soft trachea that narrows in expiration, and vocal-cord dysfunction is the glottis that closes when it should open in the adolescent.[8] Grouping them teaches the single most useful bedside skill in the noisy-airway child, which is to localise the lesion by the phase of the respiratory cycle in which the noise occurs.[8]

Laryngomalacia is the commonest cause of stridor in infancy and accounts for the large majority of congenital laryngeal problems.[2] It is a dynamic, self-limiting condition in most children, but a minority have severe disease with feeding failure, faltering growth or apnoea that needs surgery.[1] Tracheomalacia and vocal-cord dysfunction are its counterparts lower and, in age, later: each is repeatedly mistaken for asthma, and each is a classic exam trap.[4]

One-line answer for the exam

Match the age, the phase of the noise and the trigger to localise the collapse: inspiratory stridor in a feeding infant is laryngomalacia; a barking cough with expiratory wheeze unresponsive to salbutamol is tracheomalacia; and exertional inspiratory stridor with throat tightness in a teenager is vocal-cord dysfunction — most need reassurance and the right therapy, not steroid escalation.[8]

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References12ShowHide
  1. [1]Carter J, Rahbar R, Brigger M, et al. International Pediatric ORL Group (IPOG) laryngomalacia consensus recommendations. Int J Pediatr Otorhinolaryngol, 2016.PMID 27107728
  2. [2]Landry AM, Thompson DM Laryngomalacia: disease presentation, spectrum, and management. Int J Pediatr, 2012.PMID 22518182
  3. [3]Thompson DM Laryngomalacia: factors that influence disease severity and outcomes of management. Curr Opin Otolaryngol Head Neck Surg, 2010.PMID 20962644
  4. [4]Carden KA, Boiselle PM, Waltz DA, et al. Tracheomalacia and tracheobronchomalacia in children and adults: an in-depth review. Chest, 2005.PMID 15764786
  5. [5]Wallis C, Alexopoulou E, Antón-Pacheco JL, et al. ERS statement on tracheomalacia and bronchomalacia in children. Eur Respir J, 2019.PMID 31320455
  6. [6]Halvorsen T, Walsted ES, Bucca C, et al. Inducible laryngeal obstruction: an official joint European Respiratory Society and European Laryngological Society statement. Eur Respir J, 2017.PMID 28889105
  7. [7]Christensen PM, Heimdal JH, Christopher KL, et al. ERS/ELS/ACCP 2013 international consensus conference nomenclature on inducible laryngeal obstructions. Eur Respir Rev, 2015.PMID 26324806
  8. [8]Boudewyns A, Claes J, Van de Heyning P Clinical practice: an approach to stridor in infants and children. Eur J Pediatr, 2010.PMID 19763619
  9. [9]Shay EO, Sayad E, Milstein CF Exercise-induced laryngeal obstruction (EILO) in children and young adults: From referral to diagnosis. Laryngoscope, 2020.PMID 31498449
  10. [10]Karlsen T, Vreim K, Røksund OD, et al. A speech therapy treatment protocol for exercise induced laryngeal obstruction. Front Pediatr, 2024.PMID 38938504
  11. [11]Righini Grunder F, Petit LM, Ezri J, et al. Should Proton Pump Inhibitors be Systematically Prescribed in Patients With Esophageal Atresia After Surgical Repair? J Pediatr Gastroenterol Nutr, 2019.PMID 30889131
  12. [12]van der Zee DC, van Herwaarden MYA, Hulsker CCC, et al. Esophageal Atresia and Upper Airway Pathology. Clin Perinatol, 2017.PMID 29127957

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