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Paeds Topicsmental-behavioural-and-psychosomatic

Paeds · mental-behavioural-and-psychosomatic

Delirium in children and adolescents

Also known as Paediatric delirium · Pediatric delirium · PICU delirium · Acute brain dysfunction in critically ill children · Hospital-acquired delirium in children

Fellowship guide to delirium in children and adolescents: DSM-5-TR criteria-based clinical diagnosis, motoric subtypes (hyperactive, hypoactive, mixed), CAPD and pCAM-ICU screening, the ABCDEF prevention bundle, cause-first treatment with non-pharmacologic priorities, antipsychotics as last resort, and the 2022 SCCM PADIS guideline evidence.

high15 referencesUpdated 12 July 202616 min readVerification in progress

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Target exams

RACP General PaediatricsMRCPCHABP General PediatricsRCPSC Pediatrics

Red flags

  • Acute fluctuating disturbance of attention and awareness in an ill child — do not dismiss as agitation or behavioural disturbance; screen with CAPD and investigate the underlying cause
  • Hypoactive delirium is the commonest and most-missed subtype in PICU — a child who is 'quiet and comfortable' may be acutely delirious and needs active screening, not reassurance
  • Delirium in a child with new focal neurology, seizures, or a sudden drop in GCS demands urgent neuroimaging — the delirium may be the presenting sign of a CNS lesion, encephalitis, or raised intracranial pressure
  • Never reach for an antipsychotic before you have identified and treated reversible causes — infection, hypoxia, metabolic derangement, pain, withdrawal, and drug effects
  • A positive CAPD screen in a child on escalating benzodiazepines is a red flag for iatrogenic delirium — review the sedation plan, not just the behaviour

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescent

Care settings

warded-acutepicunicutelehealth

Clinical exam formats

written-only

Board mappings

  • General and Community Paediatrics
  • Mental and behavioural health
  • Acute clinical care and the critically ill child
  • Current 2026 PREP curriculum — Learning goal 5: Clinical assessment – essential general paediatrics
  • Current 2026 PREP curriculum — Learning goal 11: Recognise and manage the acutely ill child
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 5: Clinical assessment
  • Critical care and mental-health competencies
  • Clinical Applications
  • Acute and critical care
  • Long Cases
  • Short Cases
  • Communication scenarios
  • 1. Working with children and young people: Acute presentations
  • 4. Professional skills and knowledge: Patient management
  • Level 2: Assesses and manages the acutely ill child including mental-health and neurological status
  • Foundation of Practice (FOP)
  • Applied Knowledge in Practice (AKP)
  • Acute neurology and critical care
  • Clinical
  • History
  • Communication
  • Child in PICU / acute neurological assessment
  • General Pediatrics Content Outline — Domain 6: Critical Care
  • General Pediatrics Content Outline — Domain 10: Neurology
  • General Pediatrics Content Outline — Domain 15: Mental and Behavioral Health
  • General Pediatrics EPA: Recognise and manage acute neurological dysfunction
  • Patient Care 1: History and Physical Examination
  • Patient Care 4: Clinical Reasoning
  • Medical Knowledge 1: Clinical Knowledge
  • Systems-Based Practice: screening and care bundles in the PICU
  • Medical Expert
  • Collaborator
  • Pediatrics: Core EPA — Managing the acutely ill child
  • Pediatrics: Core EPA — Recognising acute neurological dysfunction
On this page

Related topics

  • Early-onset psychosis and mania
  • Mental state examination in children and adolescents
  • Anxiety disorders in children and adolescents
Study tools

Your progress

Saved on this device.

Practise this topic

  • Short-answer question1
  • Viva station1
  • Clinical case1

Target exams

RACP General PaediatricsMRCPCHABP General PediatricsRCPSC Pediatrics

Red flags

  • Acute fluctuating disturbance of attention and awareness in an ill child — do not dismiss as agitation or behavioural disturbance; screen with CAPD and investigate the underlying cause
  • Hypoactive delirium is the commonest and most-missed subtype in PICU — a child who is 'quiet and comfortable' may be acutely delirious and needs active screening, not reassurance
  • Delirium in a child with new focal neurology, seizures, or a sudden drop in GCS demands urgent neuroimaging — the delirium may be the presenting sign of a CNS lesion, encephalitis, or raised intracranial pressure
  • Never reach for an antipsychotic before you have identified and treated reversible causes — infection, hypoxia, metabolic derangement, pain, withdrawal, and drug effects
  • A positive CAPD screen in a child on escalating benzodiazepines is a red flag for iatrogenic delirium — review the sedation plan, not just the behaviour

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescent

Care settings

warded-acutepicunicutelehealth

Clinical exam formats

written-only

Board mappings

  • General and Community Paediatrics
  • Mental and behavioural health
  • Acute clinical care and the critically ill child
  • Current 2026 PREP curriculum — Learning goal 5: Clinical assessment – essential general paediatrics
  • Current 2026 PREP curriculum — Learning goal 11: Recognise and manage the acutely ill child
  • Renewed curriculum for first-year trainees from 2027 — Learning goal 5: Clinical assessment
  • Critical care and mental-health competencies
  • Clinical Applications
  • Acute and critical care
  • Long Cases
  • Short Cases
  • Communication scenarios
  • 1. Working with children and young people: Acute presentations
  • 4. Professional skills and knowledge: Patient management
  • Level 2: Assesses and manages the acutely ill child including mental-health and neurological status
  • Foundation of Practice (FOP)
  • Applied Knowledge in Practice (AKP)
  • Acute neurology and critical care
  • Clinical
  • History
  • Communication
  • Child in PICU / acute neurological assessment
  • General Pediatrics Content Outline — Domain 6: Critical Care
  • General Pediatrics Content Outline — Domain 10: Neurology
  • General Pediatrics Content Outline — Domain 15: Mental and Behavioral Health
  • General Pediatrics EPA: Recognise and manage acute neurological dysfunction
  • Patient Care 1: History and Physical Examination
  • Patient Care 4: Clinical Reasoning
  • Medical Knowledge 1: Clinical Knowledge
  • Systems-Based Practice: screening and care bundles in the PICU
  • Medical Expert
  • Collaborator
  • Pediatrics: Core EPA — Managing the acutely ill child
  • Pediatrics: Core EPA — Recognising acute neurological dysfunction
The fellowship answer

Delirium in a child or adolescent is an acute, fluctuating disturbance of attention and awareness that is the direct physiological consequence of a medical condition — it is a medical emergency, not a behavioural problem. Screen every critically ill child twice daily with an age-appropriate validated tool (CAPD for all PICU ages, pCAM-ICU for awake children ≥5 years), investigate the underlying cause, and treat cause-first with the ABCDEF prevention bundle before reaching for an antipsychotic. [1] [2]

Overview & Definition

Picture the five-year-old, three days post-cardiac surgery, who was sitting up and chatting yesterday and today cannot recognise her parents, pulls at her lines, and cannot settle to sleep. That acute change in attention and awareness in an ill child is delirium until proven otherwise — and it is far commoner than most clinicians realise. [5]

Delirium is defined by the DSM-5-TR as a disturbance in attention and awareness that develops acutely, fluctuates through the day, and represents a change from baseline, with additional disturbance in cognition, and is the direct physiological consequence of a medical condition, substance intoxication or withdrawal, or toxin exposure. It does not occur exclusively in the context of a coma, and it is not better explained by a pre-existing neurocognitive disorder. [1]

The three features that separate delirium from everything else

It is acute (hours to days, not weeks), fluctuating (lucid intervals are the hallmark — re-screen at least twice daily), and caused by a medical condition you must find and treat. Inattention is the gating symptom: without it, you cannot call it delirium. [1]

The single most important conceptual shift for paediatric trainees is this: delirium in children is not rare, not benign, and not a psychiatric diagnosis. It is acute brain dysfunction — an organ-failure equivalent of the brain — and it signals that something is physiologically wrong. The child who is acutely confused needs the same urgency as the child who is acutely hypoxic. [5] [6]

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References15ShowHide
  1. [1]Smith HAB, Besunder JB, Betters KA, et al. 2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility. Pediatr Crit Care Med, 2022.PMID 35119438
  2. [2]Traube C, Silver G, Kearney J, et al. Cornell Assessment of Pediatric Delirium: a valid, rapid, observational tool for screening delirium in the PICU*. Crit Care Med, 2014.PMID 24145848
  3. [3]Silver G, Kearney J, Traube C, et al. Delirium screening anchored in child development: The Cornell Assessment for Pediatric Delirium. Palliat Support Care, 2015.PMID 25127028
  4. [4]Ista E, Traube C, de Neef M, et al. Factors Associated With Delirium in Children: A Systematic Review and Meta-Analysis. Pediatr Crit Care Med, 2023.PMID 36790201
  5. [5]Dechnik A, Traube C, et al. Delirium in hospitalised children. Lancet Child Adolesc Health, 2020.PMID 32087768
  6. [6]Siegel EJ, Traube C, et al. Pediatric delirium: epidemiology and outcomes. Curr Opin Pediatr, 2020.PMID 33105274
  7. [7]Mody K, Kaur S, Mauer EA, et al. Benzodiazepines and Development of Delirium in Critically Ill Children: Estimating the Causal Effect. Crit Care Med, 2018.PMID 29727363
  8. [8]Traube C, Ariagno S, Thau F, et al. Delirium in Hospitalized Children with Cancer: Incidence and Associated Risk Factors. J Pediatr, 2017.PMID 29173309
  9. [9]Lin JC, Srivastava A, Malone S, et al. Caring for Critically Ill Children With the ICU Liberation Bundle (ABCDEF): Results of the Pediatric Collaborative. Pediatr Crit Care Med, 2023.PMID 37125798
  10. [10]Traube C, Silver G, et al. Identify Delirium, Then Investigate for Underlying Etiology. Pediatr Crit Care Med, 2018.PMID 29303899
  11. [11]Silver G, Doyle H, Hegel E, et al. Association Between Pediatric Delirium and Quality of Life After Discharge. Crit Care Med, 2020.PMID 33031144
  12. [12]Joyce C, Witcher R, Herrup E, et al. Evaluation of the Safety of Quetiapine in Treating Delirium in Critically Ill Children: A Retrospective Review. J Child Adolesc Psychopharmacol, 2015.PMID 26469214
  13. [13]Wainwright MS, Guilliams K, Kannan S, et al. Acute Neurologic Dysfunction in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics, 2022.PMID 34970681
  14. [14]Brown KL, Agrawal S, Kirschen MP, et al. The brain in pediatric critical care: unique aspects of assessment, monitoring, investigations, and follow-up. Intensive Care Med, 2022.PMID 35445823
  15. [15]Smith HA, Boyd J, Fuchs DC, et al. Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit Care Med, 2011.PMID 20959783

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Related topics

  • Early-onset psychosis and mania
  • Mental state examination in children and adolescents
  • Anxiety disorders in children and adolescents