Paeds · investigations-procedures-and-technology
Safe paediatric procedural sedation
Also known as Paediatric procedural sedation · Conscious sedation in children · Ketamine sedation · Nitrous oxide sedation · Dissociative sedation · Procedural sedation and analgesia
A fellowship approach to procedural sedation and analgesia in children, covering the continuum of sedation depth from minimal through moderate and deep sedation to general anaesthesia, the paediatric airway and ventilatory physiology that makes children vulnerable, the pre-sedation assessment (ASA physical status, airway, fasting and weight), the mandatory monitoring and rescue equipment, and the exact doses of ketamine (intravenous 1 to 1.5 milligrams per kilogram, intramuscular 4 to 5 milligrams per kilogram) and nitrous oxide 50 percent in oxygen. The page teaches the evidence that fasting status does not substitute for monitoring, the early detection of hypoventilation by capnography, the prevention and management of adverse events such as vomiting, emergence phenomena, laryngospasm and apnoea, the reversal agents naloxone and flumazenil, and the recovery and discharge criteria using the modified Aldrete score.
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Red flags
- A child who develops stridor, paradoxical chest movement or unexplained desaturation during sedation may have laryngospasm — clear secretions, apply sustained positive airway pressure with 100 percent oxygen via bag-valve-mask, and be ready to give suxamethonium if it does not break
- Deep sedation and general anaesthesia render a child unarousable and at risk of airway loss — these levels require anaesthetic-level training and must not be attempted by a proceduralist working alone
- An infant under one year sedated for a procedure is at markedly higher risk of apnoea and hypoxia and usually requires anaesthetic input and a higher level of monitoring and recovery
- Relying on a reversal agent such as naloxone or flumazenil to rescue oversedation is a trap — the sedative outlasts the reversal agent, so the child can re-sedate after apparently recovering; monitoring and ventilatory support come first
- Pulse oximetry alone detects hypoxia late, and supplemental oxygen masks the fall further — capnography catches the rising carbon dioxide of hypoventilation minutes earlier and is the preferred ventilatory monitor
- Proceeding with sedation without rescue airway equipment (suction, bag-valve-mask, age-appropriate airway adjuncts) immediately at the bedside is a preventable systems error
Life stages
Care settings
Clinical exam formats
Board mappings
- Investigations and procedures
- Safe use of sedation and analgesia for procedures
- Patient safety and quality
- Procedural skills — safe procedural sedation in children
- Acute and emergency paediatrics
- Current 2026 PREP curriculum — Learning Objective 1.3: Safely perform procedural sedation and analgesia, including pre-sedation assessment, monitoring and recovery
- Clinical Applications
- Medical Sciences (pharmacology of sedative agents)
- Patient safety
- Structured oral — procedural safety and sedation
- Communication in a procedural setting
- 1.4 Safely and appropriately performs practical procedures and uses medical devices
- 4. Patient management
- 8. Patient safety
- Foundation of Practice (FOP)
- Applied Knowledge in Practice (AKP)
- Clinical — structured oral on procedural safety
- General Pediatrics Content Outline — Procedural sedation; Patient safety
- Universal Task 4: Management and Treatment
- Patient Care 1: procedural competency and patient safety
- Systems-Based Practice
- Medical Expert
- Collaborator
- Pediatrics: Procedural skill — safe procedural sedation
Overview & Definition
Picture a five-year-old in the emergency department with a displaced forearm fracture, screaming in pain every time you touch the arm. To reduce and splint it safely you need the child still, calm and analgessed — but you do not want to take away their breathing. This is the everyday problem procedural sedation solves, and doing it safely is one of the most testable skills in paediatric fellowship examinations. [1]
Procedural sedation and analgesia is the deliberate, monitored depression of consciousness so that a diagnostic or therapeutic procedure can be performed, while the child's protective airway reflexes, spontaneous ventilation and cardiovascular function are preserved. The definition has two parts that sit in tension: you lower consciousness enough to make the procedure possible, but you do not lower it so far that the airway, breathing or circulation fail. The skill is choosing the depth and the agent that match the procedure and the child, and then guarding the child through it. [1] [4]
The crucial idea is that sedation is a continuum, not a switch. The American Society of Anesthesiologists and the joint American Academy of Pediatrics and American Academy of Pediatric Dentistry guidelines define four levels that shade into one another. In minimal sedation (anxiolysis) the child responds normally to voice and breathing and circulation are unaffected. In moderate or conscious sedation the child shows purposeful response to verbal command or light tactile stimulation, the airway stays open, and spontaneous ventilation is adequate. In deep sedation the child responds only purposefully to repeated or painful stimulation, the airway may need active support, and spontaneous ventilation may become inadequate. In general anaesthesia the child is unarousable even to painful stimulus, the airway usually cannot be maintained without intervention, and ventilation is frequently inadequate. The reason this matters at the bedside is that deep sedation and general anaesthesia carry the risk of airway loss and therefore require anaesthetic-level training — a proceduralist working alone must not go there. [4]
References11ShowHide
- [1]Krauss B, Green SM Procedural sedation and analgesia in children Lancet, 2006.PMID 16517277
- [2]Cravero JP, Blike GT, Beach M, et al. Incidence and nature of adverse events during pediatric sedation/anesthesia for procedures outside the operating room: report from a Pediatric Sedation Research Consortium Pediatrics, 2006.PMID 16951002
- [3]Green SM, Roback MG, Kennedy RM, et al Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update Annals of Emergency Medicine, 2011.PMID 21256625
- [4]Coté CJ, Wilson S Guidelines for Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures Pediatrics, 2019.PMID 31439084
- [5]American Society of Anesthesiologists Task Force on Preoperative Fasting Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures Anesthesiology, 1999.PMID 10078693
- [6]Green SM, Krauss B Pulmonary aspiration risk during emergency department procedural sedation--an examination of the role of fasting and sedation depth Academic Emergency Medicine, 2002.PMID 11772667
- [7]Croughan S, Barrett M, O'Sullivan R, et al. Safety and efficacy of a nitrous oxide procedural sedation programme in a paediatric emergency department: a decade of outcomes Emergency Medicine Journal, 2024.PMID 38123983
- [8]Stewart RJ, Strickland CD Hunger Games: Impact of Fasting Guidelines for Orthopedic Procedural Sedation in the Pediatric Emergency Department Journal of Emergency Medicine, 2021.PMID 33323292
- [9]Fauteux-Lamarre E, McCarthy M, Quinn N, et al. Oral Ondansetron to Reduce Vomiting in Children Receiving Intranasal Fentanyl and Inhaled Nitrous Oxide for Procedural Sedation and Analgesia Annals of Emergency Medicine, 2020.PMID 31983494
- [10]Langhan ML, Shabanova V, Li FY, et al A randomized controlled trial of capnography during sedation in a pediatric emergency setting American Journal of Emergency Medicine, 2015.PMID 25445871
- [11]Fauteux-Lamarre E, Hearps S, McCarthy M, et al Associations with early vomiting when using intranasal fentanyl and nitrous oxide for procedural sedation in children: A secondary analysis Emergency Medicine Australasia, 2025.PMID 39268662