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Paeds Topicsclinical-pharmacology-and-therapeutics

Paeds · clinical-pharmacology-and-therapeutics

Safe prescribing, administration and monitoring

Also known as Medication safety in children · Preventing paediatric medication errors · The rights of medication administration · Therapeutic drug monitoring in children · High-alert medicines and dose checking

Fellowship guide to safe prescribing, administration and monitoring of medicines in children: the medication-use process, the paediatric factors that make dosing error-prone (weight-based calculation, developmental pharmacokinetics, off-label use), where errors happen and how to stop them (the rights of administration, independent double-checks, computerised order entry with decision support, unit-based pharmacists, standard concentrations), high-alert medicines, and therapeutic drug monitoring targets for gentamicin, vancomycin and phenytoin, with ANZ, UK, US and Canada guidance.

high11 referencesUpdated 17 July 202620 min readVerification in progress

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Target exams

RACP General PaediatricsRACP DWERACP DCERCPCH Progress+MRCPCH TheoryMRCPCH ClinicalABP General PediatricsACGME PediatricsRCPSC Pediatrics

Red flags

  • Writing a weight-based dose without an independent second check, or after estimating the weight instead of weighing the child
  • A ten-fold dosing error from a misplaced decimal point, a trailing zero, or a misread unit
  • Giving a high-alert medicine (insulin, opioid, concentrated electrolyte, anticoagulant, chemotherapy) without an independent double-check
  • Missing a supratherapeutic or subtherapeutic level because a gentamicin, vancomycin or phenytoin level was not taken or not acted on
  • Reconciling medicines poorly at admission, transfer or discharge so a medicine is doubled, stopped or omitted
  • Using an abbreviation, a look-alike name, or a non-standard concentration on a free-text prescription

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescent

Care settings

preventive-medical-homecommunity-schooloutpatientwarded-acutenicupicuretrievaltelehealth

Clinical exam formats

written-onlyracp-dce-long-casemrcpch-history-managementrcpsc-structured-oral

Board mappings

  • General and Community Paediatrics — safe prescribing and medication safety
  • Quality and safety — preventing medication errors
  • Patient safety and quality improvement — medication safety systems
  • Scholarly activity — audit of medication errors and therapeutic monitoring
  • Safe prescribing, the rights of medication administration, and dose calculation
  • Therapeutic drug monitoring interpretation (gentamicin, vancomycin, phenytoin)
  • Long and short case discussion of a medication error or a high-alert medicine
  • Structured discussion of medication reconciliation at transitions of care
  • Patient safety and quality improvement: safe prescribing and medicines management
  • Safeguarding themes — recognising harm from medication errors
  • Foundation of Practice (FOP) — pharmacology and safe prescribing
  • Applied Knowledge in Practice (AKP) — medication safety and monitoring
  • History taking and management — safe prescribing and counselling
  • Communication scenarios — explaining a medication error to a family
  • General Pediatrics Content Outline — patient safety, medication management and pharmacology
  • Systems-based practice — error prevention and therapeutic drug monitoring
  • Systems-Based Practice: medication safety systems and reporting
  • Practice-Based Learning and Improvement: auditing prescribing errors
  • Patient Safety — high-alert medications and dose checking
  • Patient Safety and Quality Improvement — safe medication use
  • Medical Expert — pharmacology and therapeutic drug monitoring
  • Collaborator — working with pharmacy and nursing on medicines safety
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Your progress

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Practise this topic

  • Short-answer question1
  • Viva station1
  • Clinical case1

Target exams

RACP General PaediatricsRACP DWERACP DCERCPCH Progress+MRCPCH TheoryMRCPCH ClinicalABP General PediatricsACGME PediatricsRCPSC Pediatrics

Red flags

  • Writing a weight-based dose without an independent second check, or after estimating the weight instead of weighing the child
  • A ten-fold dosing error from a misplaced decimal point, a trailing zero, or a misread unit
  • Giving a high-alert medicine (insulin, opioid, concentrated electrolyte, anticoagulant, chemotherapy) without an independent double-check
  • Missing a supratherapeutic or subtherapeutic level because a gentamicin, vancomycin or phenytoin level was not taken or not acted on
  • Reconciling medicines poorly at admission, transfer or discharge so a medicine is doubled, stopped or omitted
  • Using an abbreviation, a look-alike name, or a non-standard concentration on a free-text prescription

Life stages

neonateinfanttoddlerpreschoolschool-ageadolescent

Care settings

preventive-medical-homecommunity-schooloutpatientwarded-acutenicupicuretrievaltelehealth

Clinical exam formats

written-onlyracp-dce-long-casemrcpch-history-managementrcpsc-structured-oral

Board mappings

  • General and Community Paediatrics — safe prescribing and medication safety
  • Quality and safety — preventing medication errors
  • Patient safety and quality improvement — medication safety systems
  • Scholarly activity — audit of medication errors and therapeutic monitoring
  • Safe prescribing, the rights of medication administration, and dose calculation
  • Therapeutic drug monitoring interpretation (gentamicin, vancomycin, phenytoin)
  • Long and short case discussion of a medication error or a high-alert medicine
  • Structured discussion of medication reconciliation at transitions of care
  • Patient safety and quality improvement: safe prescribing and medicines management
  • Safeguarding themes — recognising harm from medication errors
  • Foundation of Practice (FOP) — pharmacology and safe prescribing
  • Applied Knowledge in Practice (AKP) — medication safety and monitoring
  • History taking and management — safe prescribing and counselling
  • Communication scenarios — explaining a medication error to a family
  • General Pediatrics Content Outline — patient safety, medication management and pharmacology
  • Systems-based practice — error prevention and therapeutic drug monitoring
  • Systems-Based Practice: medication safety systems and reporting
  • Practice-Based Learning and Improvement: auditing prescribing errors
  • Patient Safety — high-alert medications and dose checking
  • Patient Safety and Quality Improvement — safe medication use
  • Medical Expert — pharmacology and therapeutic drug monitoring
  • Collaborator — working with pharmacy and nursing on medicines safety
The fellowship answer

Treat every paediatric prescription as a calculation waiting to go wrong, and build the system that catches it before it reaches the child. Children are uniquely vulnerable to medication error because nearly every dose is weight-based, the evidence base is thin, and water, renal and hepatic handling of drugs change with age. Safe practice runs the medicine through a closed loop — prescribe with a standard reference, transcribe through computerised order entry with decision support, dispense with an independent check, administer against the rights with a second checker for high-alert drugs, and monitor with therapeutic drug levels — and treats weight, high-alert drugs, transitions of care and supratherapeutic levels as the four places harm actually happens. [1] [8]

Two ideas that get blurred

A medication error

    An adverse drug event

      The rights of medication administration — every dose, every time

      Right patient (two identifiers) · Right drug (check the name, not the trade) · Right dose (independently re-calculate by weight) · Right route · Right time and frequency · Right reason and documentation. Add the modern extras an examiner rewards: right formulation, right rate for infusions, and right response by monitoring the effect. [1]

      Overview & Definition

      A four-year-old on the ward is prescribed gentamicin for a urinary infection. The dose is worked out from her weight, written on a chart, transcribed, drawn up, given over an hour, and followed by a level. Each of those steps is a chance to get it right or to harm her, and a medication error at any one of them — a misplaced decimal, a missed level, a doubled dose after transfer — can outpace the infection itself. Safe prescribing, administration and monitoring is the discipline of running a medicine through that whole chain so that the right child reliably gets the right drug, at the right dose, by the right route, at the right time, with the response checked. [1]

      Medication safety draws a clear line between an error and the harm it may cause. A medication error is any preventable event in the medication-use process that may cause or lead to inappropriate use, whether or not the child is injured; an adverse drug event is actual harm from a medicine, which may be preventable, ameliorable, or unavoidable. Most errors are intercepted or cause no harm, yet they mark a system whose next failure may not be benign, which is why safety practice hunts the error even when no child was hurt. [1] [7]

      The paediatric difference is the whole reason this topic exists as its own subject. Adults take standard doses; children almost never do. A dose depends on weight or body-surface area, on age-dependent handling of the drug, and often on an evidence base extrapolated from adults and used off-label, so the calculation step that adults skip is the single most error-prone step in children. Layer on the narrow therapeutic windows of neonatal and critical care medicines, and a safe system is not a courtesy but a necessity. [5] [10]

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      References11ShowHide
      1. [1]Kaushal R, Bates DW, Landrigan C, McKenna KJ, Clapp MD, Federico F Medication errors and adverse drug events in pediatric inpatients. JAMA, 2001.PMID 11311101
      2. [2]Fortescue EB, Kaushal R, Landrigan CP, McKenna KJ, Clapp MD, Federico F Prioritizing strategies for preventing medication errors and adverse drug events in pediatric inpatients. Pediatrics, 2003.PMID 12671103
      3. [3]Wang JK, Herzog NS, Kaushal R, Park C, Mochizuki C, Weingarten SR Prevention of pediatric medication errors by hospital pharmacists and the potential benefit of computerized physician order entry. Pediatrics, 2007.PMID 17200262
      4. [4]Kaushal R, Bates DW, Abramson EL, Soukup JR, Goldmann DA Unit-based clinical pharmacists' prevention of serious medication errors in pediatric inpatients. American journal of health-system pharmacy : AJHP, 2008.PMID 18574016
      5. [5]Conroy S, Choonara I, Impicciatore P, Mohn A, Arnell H, Rane A Survey of unlicensed and off label drug use in paediatric wards in European countries. European Network for Drug Investigation in Children. BMJ, 2000.PMID 10625257
      6. [6]Doherty C, Mc Donnell C Tenfold medication errors: 5 years' experience at a university-affiliated pediatric hospital. Pediatrics, 2012.PMID 22473367
      7. [7]Impicciatore P, Choonara I, Clarkson A, Provasi D, Pandolfini C, Bonati M Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies. British journal of clinical pharmacology, 2001.PMID 11453893
      8. [8]Maaskant JM, Vermeulen H, Apampa B, Fernando B, Ghaleb MA, Neubert A Interventions for reducing medication errors in children in hospital. Cochrane Database of Systematic Reviews, 2015.PMID 25756542
      9. [9]Lopez SA, Mulla H, Durward A, Tibby SM Extended-interval gentamicin: population pharmacokinetics in pediatric critical illness. Pediatric critical care medicine, 2010.PMID 19770786
      10. [10]Kimland E, Odlind V Off-label drug use in pediatric patients. Clinical pharmacology and therapeutics, 2012.PMID 22472984
      11. [11]Rybak MJ, Le J, Lodise T, Levine D, Bradley J, Liu C Executive Summary: Therapeutic Monitoring of Vancomycin for Serious Methicillin-Resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists. Journal of the Pediatric Infectious Diseases Society, 2020.PMID 32659787

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