Paeds Vivas · clinical-pharmacology-and-therapeutics
Safe prescribing, administration and monitoring — branching viva
Viva on safe prescribing, administration and monitoring of medicines in children, centred on a medication error and a therapeutic level.
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Opening (candidate)
I would treat this as two linked problems: a supratherapeutic gentamicin level that needs immediate action, and a system question about how we prevent high-alert-medicine errors. For the level, I would stop or extend the gentamicin, assess renal function and the child for toxicity, and review the prescribing and monitoring chain. For prevention, I would describe the layered system — decision-supported prescribing, unit-based pharmacists, standard concentrations, independent checks, reconciliation, and monitoring with level-to-action protocols. [9] [6]
You have read the opening of this viva. The complete unit — every section and its primary-source references — is part of the Paediatrics Fellowship fellowship atlas.
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- [1]Kaushal R, Bates DW, Landrigan C, McKenna KJ, Clapp MD, Federico F Medication errors and adverse drug events in pediatric inpatients. JAMA, 2001.PMID 11311101
- [2]Fortescue EB, Kaushal R, Landrigan CP, McKenna KJ, Clapp MD, Federico F Prioritizing strategies for preventing medication errors and adverse drug events in pediatric inpatients. Pediatrics, 2003.PMID 12671103
- [6]Doherty C, Mc Donnell C Tenfold medication errors: 5 years' experience at a university-affiliated pediatric hospital. Pediatrics, 2012.PMID 22473367
- [9]Lopez SA, Mulla H, Durward A, Tibby SM Extended-interval gentamicin: population pharmacokinetics in pediatric critical illness. Pediatric critical care medicine, 2010.PMID 19770786
- [11]Rybak MJ, Le J, Lodise T, Levine D, Bradley J, Liu C Executive Summary: Therapeutic Monitoring of Vancomycin for Serious Methicillin-Resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists. Journal of the Pediatric Infectious Diseases Society, 2020.PMID 32659787