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ICU TopicsResuscitation

ICU · Resuscitation

Classification and management of shock

Also known as Types of shock · Shock classification · Cardiogenic, hypovolaemic, distributive, obstructive shock

Shock is a severe supply-demand oxygen mismatch with four types: hypovolaemic (fluid replacement), distributive (vasoconstrictors plus fluids), cardiogenic (drugs/surgery/intervention), obstructive (immediate life-saving intervention). Resuscitation targets: lactate clearance, MAP 65, dynamic fluid-responsiveness testing, balanced crystalloids, noradrenaline first-line.

high28 referencesUpdated 13 Oct 202619 min readSource-verified · Oct 2026

Checked against its sources on 13 Oct 2026

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CICMFFICMEDIC

Red flags

  • Lactate elevated across shock states — track clearance (10% goal non-inferior to ScvO2 70%; 20% per 2 h goal cut adjusted mortality)
  • MAP 65 is the standard target — SEPSISPAM showed no benefit of 80-85 over 65-70
  • Anaphylaxis: prompt intramuscular adrenaline first-line (EAACI 2021)
  • Obstructive shock needs an immediate life-saving intervention — fluids and vasopressors do not relieve obstruction
  • Do NOT use protocolised EGDT with ScvO2 catheters — ProCESS/ARISE/ProMISe showed no benefit over usual care
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Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDIC

Red flags

  • Lactate elevated across shock states — track clearance (10% goal non-inferior to ScvO2 70%; 20% per 2 h goal cut adjusted mortality)
  • MAP 65 is the standard target — SEPSISPAM showed no benefit of 80-85 over 65-70
  • Anaphylaxis: prompt intramuscular adrenaline first-line (EAACI 2021)
  • Obstructive shock needs an immediate life-saving intervention — fluids and vasopressors do not relieve obstruction
  • Do NOT use protocolised EGDT with ScvO2 catheters — ProCESS/ARISE/ProMISe showed no benefit over usual care
In one line

Shock is a severe mismatch between oxygen supply and demand — the common feature of all types. Four types: (1) Hypovolaemic — intravascular volume loss, treated by fluid replacement with balanced crystalloids. (2) Distributive — relative hypovolaemia from pathological redistribution, treated with vasoconstrictors plus fluids. (3) Cardiogenic — inadequate heart function, treated with drugs, surgery or intervention. (4) Obstructive — hypoperfusion from elevated resistance, treated with an immediate life-saving intervention. Resuscitate to perfusion endpoints: lactate clearance, MAP 65, dynamic fluid-responsiveness testing.

[1] [2]

Meet the patient

A 68-year-old man arrives grey, clammy, and hypotensive. His blood pressure is 82/50, his heart rate is 128, and his skin is cool to the touch. The central question is not whether he is in shock — it is which of the four compartments has failed, because each demands a different first intervention: fluid replacement, vasoconstrictors plus fluids, cardiac drugs or intervention, or relief of the obstruction.[1]

Classify the failed compartment at the bedside before reaching for any drug. The ESICM consensus frames the bedside questions as preload and fluid responsiveness, stroke volume or cardiac output, regional and microcirculatory markers — and 44 statements to diagnose, treat and monitor shock.[2]

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References28ShowHide
  1. [1]Standl T, Annecke T, Cascorbi I, et al. The Nomenclature, Definition and Distinction of Types of Shock. Deutsches Arzteblatt international, 2018.PMID 30573009
  2. [2]Cecconi M, De Backer D, Antonelli M, et al. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive care medicine, 2014.PMID 25392034
  3. [3]Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. The New England journal of medicine, 2001.PMID 11794169
  4. [4]Muraro A, Worm M, Alviani C, et al. EAACI guidelines: Anaphylaxis (2021 update). Allergy, 2022.PMID 34343358
  5. [5]Semler MW, Self WH, Rice TW Balanced Crystalloids versus Saline in Critically Ill Adults. The New England journal of medicine, 2018.PMID 29768150
  6. [6]Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock. The New England journal of medicine, 2008.PMID 18305265
  7. [7]ProCESS Investigators, Yealy DM, Kellum JA, et al. A randomized trial of protocol-based care for early septic shock. The New England journal of medicine, 2014.PMID 24635773
  8. [8]Monnet X, Marik PE, Teboul JL Prediction of fluid responsiveness: an update. Annals of intensive care, 2016.PMID 27858374
  9. [9]Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Critical care medicine, 2006.PMID 16625125
  10. [10]De Backer D, Creteur J, Preiser JC, et al. Microvascular blood flow is altered in patients with sepsis. American journal of respiratory and critical care medicine, 2002.PMID 12091178
  11. [11]Jansen TC, van Bommel J, Schoonderbeek FJ, et al. Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. American journal of respiratory and critical care medicine, 2010.PMID 20463176
  12. [12]Jaber S, Paugam C, Futier E, et al. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. Lancet (London, England), 2018.PMID 29910040
  13. [13]De Backer D, Donadello K, Sakr Y, et al. Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Critical care medicine, 2013.PMID 23318492
  14. [14]Sakr Y, Gath V, Oishi J, et al. Characterization of buccal microvascular response in patients with septic shock. European journal of anaesthesiology, 2010.PMID 20090537
  15. [15]ARISE Investigators, ANZICS Clinical Trials Group, Peake SL, et al. Goal-directed resuscitation for patients with early septic shock. The New England journal of medicine, 2014.PMID 25272316
  16. [16]Mouncey PR, Osborn TM, Power GS, et al. Protocolised Management In Sepsis (ProMISe): a multicentre randomised controlled trial of the clinical effectiveness and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock. Health technology assessment (Winchester, England), 2015.PMID 26597979
  17. [17]Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 2016.PMID 26903338
  18. [18]Perera P, Mailhot T, Riley D, et al. The RUSH exam: Rapid Ultrasound in SHock in the evaluation of the critically lll. Emergency medicine clinics of North America, 2010.PMID 19945597
  19. [19]Ait-Oufella H, Lemoinne S, Boelle PY, et al. Mottling score predicts survival in septic shock. Intensive care medicine, 2011.PMID 21373821
  20. [20]Casserly B, Phillips GS, Schorr C, et al. Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Critical care medicine, 2015.PMID 25479113
  21. [21]Asfar P, Meziani F, Hamel JF, et al. High versus low blood-pressure target in patients with septic shock. The New England journal of medicine, 2014.PMID 24635770
  22. [22]Hernández G, Ospina-Tascón GA, Damiani LP, et al. Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial. JAMA, 2019.PMID 30772908
  23. [23]Seymour CW, Gesten F, Prescott HC, et al. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. The New England journal of medicine, 2017.PMID 28528569
  24. [24]De Backer D, Biston P, Devriendt J, et al. Comparison of dopamine and norepinephrine in the treatment of shock. The New England journal of medicine, 2010.PMID 20200382
  25. [25]Shibutani K, Komatsu T, Kubal K, et al. Critical level of oxygen delivery in anesthetized man. Critical care medicine, 1983.PMID 6409505
  26. [26]Annane D, Sébille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA, 2002.PMID 12186604
  27. [27]Jones AE, Shapiro NI, Trzeciak S, et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA, 2010.PMID 20179283
  28. [28]Kobayashi L, Costantini TW, Coimbra R Hypovolemic shock resuscitation. The Surgical clinics of North America, 2012.PMID 23153876

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