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ICU TopicsAirway management

ICU · Airway management

Extubation & Its Complications — Stridor, Laryngospasm, Pulmonary Oedema

Also known as Extubation · Extubation failure · Post-extubation stridor · Laryngeal oedema · Laryngospasm · Larson manoeuvre · Cuff leak test · Rapid shallow breathing index · Negative-pressure pulmonary oedema · Post-obstructive pulmonary oedema · Reintubation · Post-extubation dysphagia · Unplanned extubation · Airway-exchange catheter

Extubation is the planned removal of the endotracheal tube once a spontaneous breathing trial is tolerated and airway protection is adequate; it carries a 10-20 per cent reintubation rate. The serious complications are post-extubation stridor (laryngeal oedema — predicted imperfectly by the cuff-leak test, reduced by prophylactic methylprednisolone or dexamethasone in high-risk patients), laryngospasm (treat with 100 per cent oxygen, CPAP, the Larson manoeuvre and jaw thrust; a small dose of suxamethonium if refractory), negative-pressure pulmonary oedema from forceful inspiration against a closed glottis, aspiration of subglottic secretions, post-extubation dysphagia (pooled incidence around 41 per cent), and unplanned extubation. Plan high-risk extubations with senior presence, steroid pretreatment and an airway-exchange catheter, and treat every planned extubation as a potential difficult reintubation.

high15 referencesUpdated 26 July 202615 min readVerification in progress

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Extubation is the removal of the ETT once two gates are cleared — successful spontaneous breathing trial (RSBI under 105 breaths/min/L) AND airway protection (awake, cooperative, strong cough, low secretions, adequate cuff leak in the high-risk). The 10–20% reintubation rate and the clustering of complications in the first minutes after tube removal make every planned extubation a planned, equipped, staffed reintubation in waiting.[1]

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  1. [1]Lee CH, Peng MJ, Wu CL. Dexamethasone to prevent postextubation airway obstruction in adults: a prospective, randomized, double-blind, placebo-controlled study Crit Care, 2007.PMID 17605780
  2. [2]François B, Bellissant E, Gissot V, Desachy A, et al. 12-h pretreatment with methylprednisolone versus placebo for prevention of postextubation laryngeal oedema: a randomised double-blind trial Lancet, 2007.PMID 17398307
  3. [3]Yang KL, Tobin MJ. A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation N Engl J Med, 1991.PMID 2023603
  4. [4]Jaber S, Chanques G, Matecki S, Ramonatxo M, Souche B, Perrigault PF, Eledjam JJ. Post-extubation stridor in intensive care unit patients. Risk factors evaluation and importance of the cuff-leak test Intensive Care Med, 2003.PMID 12528025
  5. [5]Kuriyama A, Jackson JL, Kamei J. Performance of the cuff leak test in adults in predicting post-extubation airway complications: a systematic review and meta-analysis Crit Care, 2020.PMID 33160405
  6. [6]Markovitz BP, Randolph AG, Khemani RG. Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults Cochrane Database Syst Rev, 2008.PMID 18425866
  7. [7]McIntyre M, Doeltgen S, Dalton N, et al. Post-extubation dysphagia incidence in critically ill patients: A systematic review and meta-analysis Aust Crit Care, 2021.PMID 32739246
  8. [8]Brodsky MB, Levy MJ, Jedlanek E, Pandian V, Blackford B, Price C, et al. Laryngeal Injury and Upper Airway Symptoms After Oral Endotracheal Intubation With Mechanical Ventilation During Critical Care: A Systematic Review Crit Care Med, 2018.PMID 30096101
  9. [9]Schnell D, Planquette B, Berger A, et al. Cuff Leak Test for the Diagnosis of Post-Extubation Stridor: A Multicenter Evaluation Study J Intensive Care Med, 2019.PMID 28343416
  10. [10]Epstein SK, Nevins ML, Chung J. Effect of unplanned extubation on outcome of mechanical ventilation Am J Respir Crit Care Med, 2000.PMID 10852766
  11. [11]De Bast Y, De Backer D, Moraine JJ, et al. The cuff leak test to predict failure of tracheal extubation for laryngeal edema Intensive Care Med, 2002.PMID 12209275
  12. [12]Alalami AA, Ayoub CM, Baraka AS. Laryngospasm: review of different prevention and treatment modalities Paediatr Anaesth, 2008.PMID 18315632
  13. [13]Tara S, Tyagi R, Rai A, Naga R. Negative pressure pulmonary oedema: Rare or overlooked entity? Lung India, 2023.PMID 37961970
  14. [14]Visvanathan T, Kluger MT, Webb RK, Westhorpe RN. Crisis management during anaesthesia: laryngospasm Qual Saf Health Care, 2005.PMID 15933300
  15. [15]Estis G, Estis-Deaton A, Ezri T. Choking and laryngospasm: Exploring commonalities and treatment strategies J Crit Care Med, 2025.PMID 40017473

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