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ICU TopicsAirway management

ICU · Airway management

Difficult Airway Algorithms (DAS / ASA / CICO) & Front-of-Neck Access

Also known as Difficult airway · Difficult airway algorithm · DAS guidelines · CICO · Can't intubate can't oxygenate · Front of neck access · FONA · Cricothyroidotomy · MACOCHA score · NAP4 · Physiologically difficult airway

A difficult airway is one where a trained operator struggles with mask ventilation, laryngoscopy, or intubation. In ICU the patient is often both anatomically difficult (LEMON, MACOCHA) and physiologically difficult (shock, hypoxia, acidosis), and cannot simply be woken up. The Difficult Airway Society 2018 ICU intubation guideline structures the response into a sequence of plans (A: laryngoscopy and bougie; B: second-generation supraglottic airway rescue; C: maintain oxygenation and wake if able; CICO: front-of-neck access). CICO — can't intubate, can't oxygenate — is the life-threatening emergency requiring decisive scalpel-bougie cricothyroidotomy. The NAP4 audit showed most major airway events are avoidable: plan, assess, limit attempts, use capnography, and do not delay front-of-neck access.

high20 referencesUpdated 20 Aug 202627 min readVerification in progress

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A difficult airway in ICU is harder than in theatre for three reasons: the patient is often physiologically unstable (shock, hypoxia, acidosis), may be anatomically difficult, and cannot be woken when intubation fails. Predict difficulty with LEMON, MACOCHA, MOANS and RODS, then follow the DAS 2018 ICU algorithm — Plan A video laryngoscopy with a bougie (a maximum of three attempts), Plan B a second-generation supraglottic airway, Plan C maintain oxygenation and wake if able, and Plan CICO, scalpel-bougie front-of-neck access declared early, not late. Anticipate, preoxygenate, limit attempts, declare early.[1][2][11]

Meet the patient

A 67-year-old man with severe pneumonia and septic shock — SpO2 88 percent on 15 L/min, MAP 62 on noradrenaline — needs intubating. After induction his view is Cormack-Lehane grade 3, the tube will not pass, and the saturation is drifting down. This is the airway crisis the algorithm was written for.[1][11]

The exam question hiding in every difficult-ICU-airway stem is a single one: what is your Plan B, and when do you declare CICO? Hold that and the four plans answer themselves.[1]

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References20ShowHide
  1. [1]Higgs A, McGrath BA, Goddard C, et al. Guidelines for the management of tracheal intubation in critically ill adults. British journal of anaesthesia, 2018.PMID 29406182
  2. [2]De Jong A, Molinari N, Terzi N, et al. Early identification of patients at risk for difficult intubation in the intensive care unit: development and validation of the MACOCHA score in a multicenter cohort study. American journal of respiratory and critical care medicine, 2013.PMID 23348979
  3. [3]Lascarrou JB, Boisrame-Helms J, Bailly A, Le Thuaut A, et al.; Clinical Research in Intensive Care and Sepsis (CRICS) Group. Video Laryngoscopy vs Direct Laryngoscopy on Successful First-Pass Orotracheal Intubation Among ICU Patients: A Randomized Clinical Trial. JAMA, 2017.PMID 28118659
  4. [4]Frerk C, Mitchell VS, McNarry AF, et al. Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults. British journal of anaesthesia, 2015.PMID 26556848
  5. [5]Apfelbaum JL, Hagberg CA, Connis RT, et al.; American Society of Anesthesiologists Committee on Practice Parameters. 2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway. Anesthesiology, 2022.PMID 34762729
  6. [6]Cook TM, Woodall N, Frerk C; Fourth National Audit Project of the Royal College of Anaesthetists and Difficult Airway Society. Major complications of airway management in the UK: results of the Fourth National Audit Project (NAP4). British Journal of Anaesthesia, 2011.PMID 21447488
  7. [7]Chrimes N, Higgs A, Rehak A, et al. Lost in transition: the challenges of getting airway clinicians to move from the upper airway to the neck during an airway crisis. British Journal of Anaesthesia, 2020.PMID 32475685
  8. [8]Heard AMB, Green RJ, Eakins P. The formulation and introduction of a 'can't intubate, can't ventilate' algorithm into clinical practice. Anaesthesia, 2009.PMID 19453312
  9. [9]Aslani A, Ng SC, Hurley M, McCarthy KF, Ci K, Duggan M. Accuracy of identification of the cricothyroid membrane in female subjects using palpation: an observational study. Anesthesia and Analgesia, 2012.PMID 22366848
  10. [10]Rai D, Hilton A, Maslovitz S, Bhatia N, Otoupalova E, Smith B, Ramgopal S, Subramaniam K, Mosier JM, Mendonca C. The role of ultrasound in front-of-neck access for cricothyroid membrane identification: a systematic review. Journal of Critical Care, 2020.PMID 32836091
  11. [11]Reed MJ, Dunn MJ, McKeown DW. Can an airway assessment score predict difficulty at intubation in the emergency department? Emergency Medicine Journal, 2005.PMID 15662057
  12. [12]Mosier JM, Joshi R, Hypes C, Pacheco G, Valenzuela T, Sakles JC. The Physiologically Difficult Airway. Western Journal of Emergency Medicine, 2015.PMID 26759664
  13. [13]Russotto V, Myatra SN, Laffey JG, et al.; INTUBE Study Investigators. Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries. JAMA, 2021.PMID 33755076
  14. [14]Russotto V, Tassistro E, Myatra SN, et al.; INTUBE Study Investigators. Peri-intubation Cardiovascular Collapse in Patients Who Are Critically Ill: Insights from the INTUBE Study. American Journal of Respiratory and Critical Care Medicine, 2022.PMID 35536310
  15. [15]Karamchandani K, Nasa P, Jarzebowski M, Brewster DJ, De Jong A, et al. Tracheal intubation in critically ill adults with a physiologically difficult airway. An international Delphi study. Intensive Care Medicine, 2024.PMID 39162823
  16. [16]Cook TM, Woodall N, Harper J, Benger J; Fourth National Audit Project. Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 2: intensive care and emergency departments. British journal of anaesthesia, 2011.PMID 21447489
  17. [17]Jabre P, Combes X, Lapostolle F, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet, 2009.PMID 19573904
  18. [18]Paternò DS, La Via L, Lo Giudice EC, Sorbello M. Pharmacological approach to awake tracheal intubation. Current opinion in anaesthesiology, 2026.PMID 42228499
  19. [19]Chen F, Tan Z, He Q, Li Q. Guideline recommendations on the assessment and management of awake airway intubation: a systematic review. BMC anesthesiology, 2025.PMID 39966725
  20. [20]Perry JJ, Lee JS, Sillberg VA, Wells GA. Rocuronium versus succinylcholine for rapid sequence induction intubation. The Cochrane database of systematic reviews, 2008.PMID 18425883

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