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ICU TopicsRespiratory / ventilation

ICU · Respiratory / ventilation

Prone Ventilation — Technique & Physiology

Also known as Prone ventilation · Prone positioning · Proning · PROSEVA · Proning technique · Proning team · Proning physiology · Awake proning

Prone ventilation reduces mortality in severe ARDS (PROSEVA, NEJM 2013) by recruiting the dorsal lung, improving ventilation-perfusion matching, and reducing ventilator-induced lung injury through more uniform lung stress and strain — a benefit beyond oxygenation. Physiologically, proning places the heart on the sternum (not the lung) and flattens the pleural-pressure gradient, so the dorsal lung (the larger, healthier region) recruits and the ventral lung is less overdistended. The technique is a coordinated team procedure with a dedicated airway leader, preceded by a checklist (a secured airway, lines managed, eye and pressure-area protection, gastric decompression, adequate sedation), with the patient kept prone for at least 16 hours. The complications — accidental extubation, line loss, and pressure injury — are minimised by a trained team.

high19 referencesUpdated 20 Aug 202624 min readVerification in progress

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The one-line answer

Prone ventilation is early, prolonged lung protection for severe ARDS: when the PaO2/FiO2 remains under 150 on FiO2 at least 0.60 and PEEP at least 5, turn a secured, sedated patient with a trained team and keep them prone for at least 16 hours. PROSEVA reduced mortality because proning homogenises stress and strain, not merely because oxygenation improves.[1]

Meet the patient

A ventilated patient with influenza ARDS has a PaO2/FiO2 of 82 despite lung-protective settings, PEEP 12 and FiO2 0.75. The airway is secure, but the team has delayed proning because the blood pressure is supported with a low-dose vasopressor.[1]

The answer is prone now, safely and for long enough. Do not wait for refractory hypoxaemia; the survival benefit is a planned intervention, not a rescue flip.[1]

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References19ShowHide
  1. [1]Guérin C, Reignier J, Richard JC, et al. Prone positioning in severe acute respiratory distress syndrome N Engl J Med, 2013.PMID 23688302
  2. [2]Gattinoni L, Tognoni G, Pesenti A, et al. Effect of prone positioning on the survival of patients with acute respiratory failure N Engl J Med, 2001.PMID 11529210
  3. [3]Mancebo J, Fernández R, Blanch L, et al. A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome Am J Respir Crit Care Med, 2006.PMID 16556697
  4. [4]Taccone P, Pesenti A, Latini R, et al. Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial JAMA, 2009.PMID 19903918
  5. [5]Sud S, Friedrich JO, Taccone P, et al. Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis Intensive Care Med, 2010.PMID 20130832
  6. [6]Munshi L, Del Sorbo L, Adhikari NKJ, et al. Prone Position for Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis Ann Am Thorac Soc, 2017.PMID 29068269
  7. [7]Ehrmann S, Li J, Ibarra-Estrada M, et al. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial Lancet Respir Med, 2021.PMID 34425070
  8. [8]Li J, Luo J, Pavlov I, et al. Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis Lancet Respir Med, 2022.PMID 35305308
  9. [9]Beran A, Mhanna M, Srour O, et al. Effect of Prone Positioning on Clinical Outcomes of Non-Intubated Subjects With COVID-19 Respir Care, 2022.PMID 34753813
  10. [10]Abroug F, Ouanes-Besbes L, Dachraoui F, et al. An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury Crit Care, 2011.PMID 21211010
  11. [11]Alsarayreh M, Moawad MHED, Barham H, et al. Awake prone positioning reduces mortality, intubation, and hospital stay in acute hypoxemic respiratory failure: a systematic review and meta-analysis of 6,164 patients BMC Anesthesiol, 2026.PMID 42210098
  12. [12]Liu L, Sun Q, Zhao H, et al. Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial Intensive Care Med, 2024.PMID 39088076
  13. [13]Ranieri VM, Rubenfeld GD, Thompson BT, et al. Acute respiratory distress syndrome: the Berlin Definition JAMA, 2012.PMID 22797452
  14. [14]Brower RG, Matthay MA, Morris A, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome N Engl J Med, 2000.PMID 10793162
  15. [15]Amato MB, Meade MO, Slutsky AS, et al. Driving pressure and survival in the acute respiratory distress syndrome N Engl J Med, 2015.PMID 25693014
  16. [16]Moscarelli A, Iozzo P, Ippolito M, et al. Cardiopulmonary resuscitation in prone position: A scoping review Am J Emerg Med, 2020.PMID 33046293
  17. [17]Anez C, Becerra-Bolaños Á, Vives-Lopez A, et al. Cardiopulmonary Resuscitation in the Prone Position in the Operating Room or in the Intensive Care Unit: A Systematic Review Anesth Analg, 2021.PMID 33086246
  18. [18]Walter T, Ricard JD Extended prone positioning for intubated ARDS: a review Crit Care, 2023.PMID 37408074
  19. [19]Gattinoni L, Taccone P, Carlesso E, Marini JJ Prone position in acute respiratory distress syndrome. Rationale, indications, and limits Am J Respir Crit Care Med, 2013.PMID 24134414

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