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ICU TopicsRespiratory / ventilation

ICU · Respiratory / ventilation

Pneumonia — CAP, HAP, VAP & Aspiration

Also known as Pneumonia · Community-acquired pneumonia · CAP · Hospital-acquired pneumonia · HAP · Ventilator-associated pneumonia · VAP · Aspiration pneumonia · CURB-65 · IDSA/ATS criteria

Pneumonia is classified by the setting of acquisition: community-acquired (CAP, outside hospital or within 48 hours of admission), hospital-acquired (HAP, after 48 hours in hospital), ventilator-associated (VAP, after 48 hours of intubation), and aspiration. The severity is graded by CURB-65, PSI, or the IDSA/ATS severe-CAP criteria. The commonest CAP pathogen is Streptococcus pneumoniae; atypicals (Mycoplasma, Legionella, Chlamydia) are also important. Late-onset HAP/VAP introduces multidrug-resistant organisms (Pseudomonas, MRSA, ESBL). The empirical antibiotics are guided by the setting, the severity, and the local antibiogram; de-escalate once the cultures identify the organism. Duration is typically 5-7 days for CAP and 7 days for VAP.

high10 referencesUpdated 26 July 20264 min readVerification in progress

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The one-line answer

Classify pneumonia by where and when it began, assess severity and respiratory failure, obtain appropriate cultures without delaying therapy in shock, start empiric antibiotics from local ecology and resistance risk, then narrow promptly and secure source control. CAP, HAP, VAP, and aspiration are different probability maps, not interchangeable labels.[1][6]

Meet the patient

A patient admitted from home with lobar consolidation and shock needs immediate severe-CAP treatment. Three beds away, another patient develops fever, purulent secretions, and a new infiltrate after several ventilated days. Both have pneumonia; only one should make you assume hospital flora and device-associated risk.[1][6]

The mantra: setting predicts pathogens, severity sets urgency, cultures permit narrowing.[1][6]

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References10ShowHide
  1. [1]Metlay JP, Waterer GW, Long AC, et al. Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America. American Journal of Respiratory and Critical Care Medicine, 2019.PMID 31573350
  2. [2]Karnad DR, Nor MBM, Richards GA, et al. Intensive care in severe malaria: Report from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine. Journal of critical care, 2018.PMID 29132978
  3. [3]Chastre J, Wolff M, Fagon JY, Chevret S, et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial (PNEUMA). JAMA, 2003.PMID 14625336
  4. [4]Lim WS, van der Eerden MM, Laing R, et al. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study (CURB-65). Thorax, 2003.PMID 12728155
  5. [5]Fine MJ, Auble TE, Yealy DM, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia (Pneumonia Severity Index / PORT). New England Journal of Medicine, 1997.PMID 8995086
  6. [6]Kalil AC, Metersky ML, Klompas M, et al. Executive Summary: Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the IDSA and ATS. Clinical Infectious Diseases, 2016.PMID 27521441
  7. [7]Drakulovic MB, Torres A, Bauer TT, et al. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients. Lancet, 1999.PMID 10584721
  8. [8]Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial). Lancet, 2008.PMID 18191684
  9. [9]Bouadma L, Luyt CE, Tubach F, et al. Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial). Lancet, 2010.PMID 20097417
  10. [10]Schuetz P, Wirz Y, Sager R, et al. Procalcitonin guidance in patients with lower respiratory tract infections: a systematic review and meta-analysis. Clinical Chemistry and Laboratory Medicine, 2018.PMID 29715176

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