ICU · Respiratory / ventilation
Pneumonia — CAP, HAP, VAP & Aspiration
Also known as Pneumonia · Community-acquired pneumonia · CAP · Hospital-acquired pneumonia · HAP · Ventilator-associated pneumonia · VAP · Aspiration pneumonia · CURB-65 · IDSA/ATS criteria
Pneumonia is classified by the setting of acquisition: community-acquired (CAP, outside hospital or within 48 hours of admission), hospital-acquired (HAP, after 48 hours in hospital), ventilator-associated (VAP, after 48 hours of intubation), and aspiration. The severity is graded by CURB-65, PSI, or the IDSA/ATS severe-CAP criteria. The commonest CAP pathogen is Streptococcus pneumoniae; atypicals (Mycoplasma, Legionella, Chlamydia) are also important. Late-onset HAP/VAP introduces multidrug-resistant organisms (Pseudomonas, MRSA, ESBL). The empirical antibiotics are guided by the setting, the severity, and the local antibiogram; de-escalate once the cultures identify the organism. Duration is typically 5-7 days for CAP and 7 days for VAP.
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A patient admitted from home with lobar consolidation and shock needs immediate severe-CAP treatment. Three beds away, another patient develops fever, purulent secretions, and a new infiltrate after several ventilated days. Both have pneumonia; only one should make you assume hospital flora and device-associated risk.[1][6]
The mantra: setting predicts pathogens, severity sets urgency, cultures permit narrowing.[1][6]
References10ShowHide
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- [3]Chastre J, Wolff M, Fagon JY, Chevret S, et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial (PNEUMA). JAMA, 2003.PMID 14625336
- [4]Lim WS, van der Eerden MM, Laing R, et al. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study (CURB-65). Thorax, 2003.PMID 12728155
- [5]Fine MJ, Auble TE, Yealy DM, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia (Pneumonia Severity Index / PORT). New England Journal of Medicine, 1997.PMID 8995086
- [6]Kalil AC, Metersky ML, Klompas M, et al. Executive Summary: Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the IDSA and ATS. Clinical Infectious Diseases, 2016.PMID 27521441
- [7]Drakulovic MB, Torres A, Bauer TT, et al. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients. Lancet, 1999.PMID 10584721
- [8]Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial). Lancet, 2008.PMID 18191684
- [9]Bouadma L, Luyt CE, Tubach F, et al. Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial). Lancet, 2010.PMID 20097417
- [10]Schuetz P, Wirz Y, Sager R, et al. Procalcitonin guidance in patients with lower respiratory tract infections: a systematic review and meta-analysis. Clinical Chemistry and Laboratory Medicine, 2018.PMID 29715176