RRT modality selection: IHD vs CRRT vs SLED — when and why

Also known as RRT modality · Intermittent haemodialysis · Continuous renal replacement therapy · SLED · Sustained low-efficiency dialysis · Haemodialysis ICU

Choosing renal replacement therapy in the ICU — IHD versus CRRT versus SLED (Vinsonneau 2006, nine-trial meta-analysis, SLED cohort), the KDIGO dialysis-chapter recommendations (CRRT for instability and brain injury, dose 20-25 mL/kg/h, citrate, access, bicarbonate buffer), dialysis disequilibrium, timing trials (Gaudry 2016, IDEAL-ICU, STARRT-AKI, ELAIN), dose (Bellomo 2009, Palevsky 2008), citrate versus heparin (Zarbock 2020), circuit losses and liberation from RRT.

high37 referencesUpdated 8 Oct 20269 min readSource-verified · Oct 2026

Checked against its sources on 8 Oct 2026

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Meet the patient

A 64-year-old man in septic shock on high-dose noradrenaline has oliguric AKI, rising potassium and a large positive fluid balance. The question is not whether to replace kidney function but how — and the answer turns on what his circulation will tolerate.^[35]

References37Show

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