ICU · Neurocritical Care
Aneurysmal subarachnoid haemorrhage
Also known as Subarachnoid haemorrhage (SAH) · Aneurysmal SAH · Vasospasm · Nimodipine · WFNS grading · Cerebral salt wasting
Aneurysmal subarachnoid haemorrhage in the ICU — epidemiology, CT sensitivity by time and the Ottawa SAH Rule, modified Fisher grading, the 2026 ESO/EANS/ESMINT guideline (oral nimodipine, coiling when both options suit, treatment within 24 h, no antifibrinolytics, statins, magnesium or endothelin antagonists), ISAT, DCI definition and monitoring, induced hypertension (Gathier RCT), hyponatraemia and systems of care.
Checked against its sources on 8 Oct 2026
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Red flags
- CT is 100% sensitive only within 6 hours of headache onset — overall sensitivity was 92.9%
- Oral nimodipine for every patient — intravenous nimodipine was not statistically significant in the Cochrane review
- No routine antifibrinolytics before aneurysm treatment (ULTRA: no reduction in poor outcome)
- MAP below 60 mmHg was associated with increased risk of delayed cerebral ischaemia
- Induced hypertension for DCI is unproven — the only RCT showed no benefit and more serious adverse events
Meet the patient
A 52-year-old woman develops a sudden, severe headache while folding laundry, vomits once and develops neck stiffness. Severe sudden-onset headache is the most common presenting symptom of SAH, variably with meningismus and transient or prolonged loss of consciousness. Two questions decide her next fortnight: is there blood on CT, and can the aneurysm be secured before it rebleeds?[1][30]
References31ShowHide
- [1]Claassen J, Park S Spontaneous subarachnoid haemorrhage Lancet, 2022.PMID 35985353
- [2]Macdonald RL, Schweizer TA Spontaneous subarachnoid haemorrhage Lancet, 2017.PMID 27637674
- [3]Hoh BL, Ko NU, Amin-Hanjani S, et al. 2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association Stroke, 2023.PMID 37212182
- [4]Pickard JD, Murray GD, Illingworth R, et al. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial BMJ, 1989.PMID 2496789
- [5]Dorhout Mees SM, Rinkel GJ, Feigin VL, et al. Calcium antagonists for aneurysmal subarachnoid haemorrhage Cochrane Database Syst Rev, 2007.PMID 17636626
- [6]Molyneux A, Kerr R, Stratton I, et al. International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial Lancet, 2002.PMID 12414200
- [7]Molyneux AJ, Kerr RS, Yu LM, et al. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion Lancet, 2005.PMID 16139655
- [8]Molyneux AJ, Birks J, Clarke A, et al. The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT) Lancet, 2015.PMID 25465111
- [9]Perry JJ, Stiell IG, Sivilotti ML, et al. Sensitivity of computed tomography performed within six hours of onset of headache for diagnosis of subarachnoid haemorrhage: prospective cohort study BMJ, 2011.PMID 21768192
- [10]Perry JJ, Stiell IG, Sivilotti ML, et al. Clinical decision rules to rule out subarachnoid hemorrhage for acute headache JAMA, 2013.PMID 24065011
- [11]Perry JJ, Sivilotti MLA, Sutherland J, et al. Validation of the Ottawa Subarachnoid Hemorrhage Rule in patients with acute headache CMAJ, 2017.PMID 29133539
- [12]Frontera JA, Claassen J, Schmidt JM, et al. Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale Neurosurgery, 2006.PMID 16823296
- [13]Vergouwen MD, Vermeulen M, van Gijn J, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group Stroke, 2010.PMID 20798370
- [14]Kirkpatrick PJ, Turner CL, Smith C, et al. Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): a multicentre randomised phase 3 trial Lancet Neurol, 2014.PMID 24837690
- [15]Macdonald RL, Kassell NF, Mayer S, et al. Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, double-blind, placebo-controlled phase 2 dose-finding trial Stroke, 2008.PMID 18688013
- [16]Macdonald RL, Higashida RT, Keller E, et al. Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2) Lancet Neurol, 2011.PMID 21640651
- [17]Macdonald RL, Higashida RT, Keller E, et al. Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling Stroke, 2012.PMID 22403047
- [18]Matsuda N, Naraoka M, Ohkuma H, et al. Effect of Cilostazol on Cerebral Vasospasm and Outcome in Patients with Aneurysmal Subarachnoid Hemorrhage: A Randomized, Double-Blind, Placebo-Controlled Trial Cerebrovasc Dis, 2016.PMID 27070952
- [19]Diringer MN, Bleck TP, Claude Hemphill J 3rd, et al. Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference Neurocrit Care, 2011.PMID 21773873
- [20]Brathwaite S, Macdonald RL Current management of delayed cerebral ischemia: update from results of recent clinical trials Transl Stroke Res, 2014.PMID 24338266
- [21]Gathier CS, van den Bergh WM, Slooter AJC, et al. Induced Hypertension for Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial Stroke, 2018.PMID 29158449
- [22]Gathier CS, Zijlstra IAJ, Rinkel GJE, et al. Blood pressure and the risk of rebleeding and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage J Crit Care, 2022.PMID 36208555
- [23]Cuesta M, Thompson CJ Diagnosis and treatment of hyponatraemia in neurosurgical patients Endocrinol Nutr, 2016.PMID 26965574
- [24]Cui H, He G, Yang C, et al. Inappropriate Antidiuretic Hormone Secretion and Cerebral Salt-Wasting Syndromes in Neurological Patients Front Neurosci, 2019.PMID 31780881
- [25]Shah K, Turgeon RD, Gooderham PA, et al. Prevention and Treatment of Hyponatremia in Patients with Subarachnoid Hemorrhage: A Systematic Review World Neurosurg, 2018.PMID 28987848
- [26]Katayama Y, Haraoka J, Hirabayashi H, et al. A randomized controlled trial of hydrocortisone against hyponatremia in patients with aneurysmal subarachnoid hemorrhage Stroke, 2007.PMID 17585086
- [27]Suppadungsuk S, Krisanapan P, Kazeminia S, et al. Hyponatremia Correction and Osmotic Demyelination Syndrome Risk: A Systematic Review and Meta-Analysis Kidney Med, 2025.PMID 39967825
- [28]Vora YY, Suarez-Almazor M, Steinke DE, et al. Role of transcranial Doppler monitoring in the diagnosis of cerebral vasospasm after subarachnoid hemorrhage Neurosurgery, 1999.PMID 10371622
- [29]Busl KM, Bogossian EG, Claassen J, et al. Beyond the bleed: complications after aneurysmal subarachnoid hemorrhage. Pathophysiology, clinical implications, and management strategies: a review Crit Care, 2025.PMID 41029753
- [30]Vergouwen MDI, Ramos-Pachon A, Terecoasa EO, et al. European Stroke Organisation (ESO), European Association of Neurosurgical Societies (EANS) and European Society for Minimally Invasive Neurological Therapy (ESMINT) guideline on aneurysmal subarachnoid haemorrhage. European stroke journal, 2026.PMID 42095754
- [31]Abdulazim A, Heilig M, Rinkel G, et al. Diagnosis of Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage and Triggers for Intervention. Neurocritical care, 2023.PMID 37537496