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ICU TopicsNeurocritical care

ICU · Neurocritical care

Acute stroke: ischaemic, haemorrhagic, and SAH — comprehensive ICU management

Also known as Acute stroke · Ischaemic stroke · Intracerebral haemorrhage · ICH · Subarachnoid haemorrhage · Thrombolysis · Thrombectomy

Acute stroke = sudden neurological deficit from cerebral vascular event. THREE TYPES: (1) ISCHAEMIC (about 85% — arterial occlusion — thrombus/embolus). (2) INTRACEREBRAL HAEMORRHAGE [ICH] (10-15% — intraparenchymal bleed — hypertension/amyloid). (3) SUBARACHNOID HAEMORRHAGE [SAH] (5-7% — aneurysmal rupture). ISCHAEMIC: THROMBOLYSIS (alteplase within 4.5h — NINDS/ECASS III) + THROMBECTOMY (DAWN/DEFUSE-3 — for large vessel occlusion [LVO] within 6-24h with salvageable penumbra). ICH: BP control (SBP <140 — INTERACT2/ATACH-2), ICH score for prognosis, surgical evacuation (CEREBELLAR — life-saving; SUPRATENTORIAL — STICH II — no routine benefit). SAH: nimodipine (reduces vasospasm + improves outcomes — 60 mg PO q4h x 21 days), BP control (SBP <160 pre-aneurysm securing), vasospasm management (induced hypertension — but NOT triple-H — avoid hypervolaemia). ICU: BP (permissive hypertension for ischaemic [SBP <185 for thrombolysis, <140 for ICH]), temperature (normothermia — fever worsens outcomes), glucose (avoid hypo- and marked hyperglycaemia), swallowing assessment (before oral intake), DVT prophylaxis (LMWH). MORTALITY: ischaemic 10-15%; ICH 35-50%; SAH 30-40%.

high34 referencesUpdated 26 July 202615 min readSource-verified · Sept 2026

Checked against its sources on 11 Sept 2026

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Red flags

  • Ischaemic: THROMBOLYSIS within 4.5h (alteplase 0.9 mg/kg) — DAWN/DEFUSE-3: thrombectomy up to 24h for LVO
  • ICH: BP SBP &lt;140 (INTERACT2) — ICH score for prognosis — cerebellar haematoma with compression/deterioration → surgical evacuation
  • SAH: nimodipine 60 mg PO q4h x 21 days — vasospasm days 4-14
  • CT brain immediately (ischaemic vs haemorrhagic — determines management)
  • Swallow assessment BEFORE any oral intake (aspiration risk)
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Practise this topic8 MCQs with explanations

Target exams

CICMFFICMEDIC

Red flags

  • Ischaemic: THROMBOLYSIS within 4.5h (alteplase 0.9 mg/kg) — DAWN/DEFUSE-3: thrombectomy up to 24h for LVO
  • ICH: BP SBP &lt;140 (INTERACT2) — ICH score for prognosis — cerebellar haematoma with compression/deterioration → surgical evacuation
  • SAH: nimodipine 60 mg PO q4h x 21 days — vasospasm days 4-14
  • CT brain immediately (ischaemic vs haemorrhagic — determines management)
  • Swallow assessment BEFORE any oral intake (aspiration risk)
The one-line answer

Acute stroke is one symptom — sudden focal neurological deficit — read through one scan, and that scan splits the whole topic in three. Ischaemic stroke (roughly 85 percent) wants the artery opened: alteplase within 4.5 hours plus thrombectomy for a large-vessel occlusion out to 24 hours with perfusion-mismatch selection. Intracerebral haemorrhage (about 10 to 15 percent) wants the pressure lowered to systolic under 140 mmHg, the ICH score for prognosis, and a compressive cerebellar haematoma evacuated. Subarachnoid haemorrhage (about 5 percent) wants nimodipine 60 mg orally every four hours for 21 days, the aneurysm secured early by coiling or clipping, and vasospasm met with induced hypertension, not hypervolaemia.[17][3][6][7][22][13][9][33]

Meet the patient

A 68-year-old man is wheeled into your resuscitation bay at 03:00. His wife says he was normal at midnight and woke to find his right side "gone" — face drooped, arm useless, speech slurred. Blood pressure 196/104, glucose 11, GCS 13. The CT scanner is being warmed up before you finish your examination.[20]

The first question. Is the artery blocked or has it burst? The non-contrast CT answers it within minutes, and everything you do — lower the pressure or let it run high, lyse or do not lyse, call the interventional suite or the neurosurgeon — flows from that one image.[1]

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References34ShowHide
  1. [1]Campbell BCV, Khatri P, et al. Stroke. Lancet, 2020.PMID 32653056
  2. [2]The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group Tissue plasminogen activator for acute ischemic stroke. N Engl J Med, 1995.PMID 7477192
  3. [3]Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med, 2008.PMID 18815396
  4. [4]Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med, 2018.PMID 29129157
  5. [5]Albers GW, Marks MP, Kemp S, et al. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging. N Engl J Med, 2018.PMID 29364767
  6. [6]Anderson CS, Heeley E, Huang Y, et al. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med, 2013.PMID 23713578
  7. [7]Hemphill JC 3rd, Bonovich DC, Besmertis L, et al. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke, 2001.PMID 11283388
  8. [8]Mendelow AD, Gregson BA, Rowan EN, et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial. Lancet, 2013.PMID 23726393
  9. [9]Molyneux A, Kerr R, Stratton I, et al. International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet, 2002.PMID 12414200
  10. [10]Vahedi K, Hofmeijer J, Juettler E, et al. Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol, 2007.PMID 17303527
  11. [11]Jüttler E, Unterberg A, Woitzik J, et al. Hemicraniectomy in older patients with extensive middle-cerebral-artery stroke. N Engl J Med, 2014.PMID 24645942
  12. [12]Dorhout Mees SM, Rinkel GJ, Feigin VL, et al. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev, 2007.PMID 17636626
  13. [13]Pickard JD, Murray GD, Illingworth R, et al. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. BMJ, 1989.PMID 2496789
  14. [14]Perry JJ, Stiell IG, Sivilotti ML, et al. Sensitivity of computed tomography performed within six hours of onset of headache for diagnosis of subarachnoid haemorrhage: prospective cohort study. BMJ, 2011.PMID 21768192
  15. [15]Jain AR, Bellolio MF, Stead LG, et al. Treatment of hypertension in acute ischemic stroke. Curr Treat Options Neurol, 2009.PMID 19210914
  16. [16]Anderson CS, Huang Y, Lindley RI, et al. Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial. Lancet, 2019.PMID 30739745
  17. [17]Bevers MB, Kimberly WT, et al. Critical Care Management of Acute Ischemic Stroke. Curr Treat Options Cardiovasc Med, 2017.PMID 28466119
  18. [18]Saver JL, et al. Time is brain--quantified. Stroke, 2006.PMID 16339467
  19. [19]Fonarow GC, Zhao X, Smith EE, et al. Door-to-needle times for tissue plasminogen activator administration and clinical outcomes in acute ischemic stroke before and after a quality improvement initiative. JAMA, 2014.PMID 24756513
  20. [20]Whiteley WN, Wardlaw JM, Dennis MS, et al. Clinical scores for the identification of stroke and transient ischaemic attack in the emergency department: a cross-sectional study. J Neurol Neurosurg Psychiatry, 2011.PMID 21402744
  21. [21]Kothari RU, Brott T, Broderick JP, et al. The ABCs of measuring intracerebral hemorrhage volumes. Stroke, 1996.PMID 8711791
  22. [22]Witsch J, Neugebauer H, Zweckberger K, et al. Primary cerebellar haemorrhage: complications, treatment and outcome. Clin Neurol Neurosurg, 2013.PMID 23659765
  23. [23]Martino R, Foley N, Bhogal S, et al. Dysphagia after stroke: incidence, diagnosis, and pulmonary complications. Stroke, 2005.PMID 16269630
  24. [24]Sherman DG, Albers GW, Bladin C, et al. The efficacy and safety of enoxaparin versus unfractionated heparin for the prevention of venous thromboembolism after acute ischaemic stroke (PREVAIL Study): an open-label randomised comparison. Lancet, 2007.PMID 17448820
  25. [25]Dennis M, Sandercock P, Reid J, et al. Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3): a multicentre randomised controlled trial. Lancet, 2013.PMID 23727163
  26. [26]Capes SE, Hunt D, Malmberg K, et al. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke, 2001.PMID 11588337
  27. [27]Brathwaite S, Macdonald RL, et al. Current management of delayed cerebral ischemia: update from results of recent clinical trials. Transl Stroke Res, 2014.PMID 24338266
  28. [28]Brunser AM, Ouyang M, Arima H, et al. No benefit of flat head positioning in early moderate-severe acute ischaemic stroke: a HeadPoST study subgroup analysis. Stroke Vasc Neurol, 2020.PMID 32591406
  29. [29]Menon BK, Buck BH, Singh N, et al. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial. Lancet, 2022.PMID 35779553
  30. [30]Yan S, Zhou Y, Lansberg MG, et al. Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours. N Engl J Med, 2025.PMID 40174223
  31. [31]de Jonge JC, Wallet J, van der Worp HB, et al. Fever worsens outcomes in animal models of ischaemic stroke: A systematic review and meta-analysis. Eur Stroke J, 2019.PMID 31165092
  32. [32]Kikuta Y, Kubota Y, Nakamoto H, et al. Nonconvulsive status epilepticus after surgery for ruptured intracranial aneurysms: Incidence, associated factors, and impact on the outcome. Clin Neurol Neurosurg, 2021.PMID 33268192
  33. [33]Gathier CS, van den Bergh WM, van der Jagt M, et al. Induced Hypertension for Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial. Stroke, 2018.PMID 29158449
  34. [34]Zoumprouli A, Carden R, Bilotta F, et al. Current and novel approaches for critical care management of aneurysmal subarachnoid hemorrhage in critical care. Curr Opin Anaesthesiol, 2025.PMID 40493770

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