ICU · Environmental
Acute severe hypothermia: rewarming, Osborn waves, and 'warm and dead'
Also known as Hypothermia · Accidental hypothermia · Environmental hypothermia · Osborn waves · Rewarming · Warm and dead
Hypothermia = core temperature <35°C from excessive heat loss (environmental) or impaired thermogenesis (endocrine, sepsis, drugs). SEVERITY: MILD (32-35°C — tachycardia, tachypnoea, shivering, confusion). MODERATE (28-32°C — bradycardia, decreased reflexes, somnolence, shivering stops, Osborn J waves on ECG, AF). SEVERE (<28°C — coma, fixed pupils, hypotension, ventricular arrhythmias [VF], asystole, pulseless — appears dead but may be recoverable). KEY PRINCIPLES: (1) HANDLE GENTLY — cold myocardium is extremely irritable — rough handling/movement → VF (irreversible). (2) REWARM: mild → passive (blankets, warm environment); moderate → active external (forced warm air [Bair Hugger], warmed IV fluids); severe → active internal (warmed fluids + body cavity lavage + ECMO/cardiopulmonary bypass). (3) 'NO ONE IS DEAD UNTIL WARM AND DEAD' — prolonged resuscitation is warranted; survivors rewarmed from 13.7°C. (4) DON'T RUB/MASSAGE (triggers VF). (5) GUIDELINES do not recommend vasopressor or antiarrhythmic drugs in VF if <30°C — treat with CPR and extracorporeal rewarming.
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Red flags
- 'No one is dead until warm and dead' — continue resuscitation until core temp ≥32°C
- HANDLE GENTLY — cold myocardium irritable — movement triggers VF
- Osborn J waves (positive deflection at J point) — pathognomonic for hypothermia
- Rewarming: passive (mild) → active external (moderate) → active internal/ECMO (severe <28°C)
- Resuscitation drugs are not recommended in VF below 30°C — CPR and extracorporeal rewarming
Meet the patient
A 64-year-old man is brought to your department unconscious after a witnessed collapse in a winter park, where he lay for 6 to 8 hours. He smells of alcohol. The rectal temperature on a low-reading thermometer is 29.8 degrees C; he is somnolent (GCS 9), not shivering, bradycardic at 38 with a blood pressure of 88/54. The ECG shows sinus bradycardia with a prominent positive deflection at the junction of the QRS and ST in the lateral leads.[2]
Two questions frame everything that follows: how cold is the core? (a low-reading probe answers it) and what stopped the patient making heat? (alcohol, exposure, or a hidden endocrine or septic cause). Miss the second and you rewarm a corpse with an undiagnosed myxoedema coma.[4]
References20ShowHide
- [1]Brown DJ, et al. Accidental hypothermia. The New England journal of medicine, 2012.PMID 23150960
- [2]Gordon L, et al. Extracorporeal life support . Is recommended for severe accidental hypothermia. BMJ (Clinical research ed.), 2010.PMID 21193508
- [3]Dow J, et al. Wilderness Medical Society Clinical Practice Guidelines for the Out-of-Hospital Evaluation and Treatment of Accidental Hypothermia: 2019 Update. Wilderness & environmental medicine, 2019.PMID 31740369
- [4]Mallet ML Pathophysiology of accidental hypothermia. QJM : monthly journal of the Association of Physicians, 2002.PMID 12454320
- [5]Svendsen OS, et al. Outcome After Rewarming From Accidental Hypothermia by Use of Extracorporeal Circulation. The Annals of thoracic surgery, 2017.PMID 27692232
- [6]Lott C, et al. European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances. Resuscitation, 2021.PMID 33773826
- [7]Paal P, et al. Accidental hypothermia: 2021 update. International journal of environmental research and public health, 2022.PMID 35010760
- [8]Mazur P, et al. Extracorporeal membrane oxygenation for accidental deep hypothermia: current challenges and future perspectives. Annals of cardiothoracic surgery, 2019.PMID 30854323
- [9]Pasquier M, et al. Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: the HOPE score. Resuscitation, 2018.PMID 29481910
- [10]Pasquier M, et al. Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: an external validation of the HOPE score. Resuscitation, 2019.PMID 30940473
- [11]Saczkowski R, et al. Extracorporeal life support rewarming rate is associated with survival with good neurological outcome in accidental hypothermia. European journal of cardio-thoracic surgery, 2021.PMID 33230533
- [12]Hilmo J, et al. "Nobody is dead until warm and dead": prolonged resuscitation is warranted in arrested hypothermic victims also in remote areas: a retrospective study from northern Norway. Resuscitation, 2014.PMID 24882104
- [13]Gilbert M, et al. Resuscitation from accidental hypothermia of 13.7 degrees C with circulatory arrest. The Lancet, 2000.PMID 10665559
- [14]Omar HR, et al. The correlation between the amplitude of Osborn wave and core body temperature. European heart journal. Acute cardiovascular care, 2015.PMID 25267877
- [15]Wira C, et al. Application of normothermic cardiac arrest algorithms to hypothermic cardiac arrest in a canine model. Resuscitation, 2006.PMID 16597482
- [16]Avellanas Chavala ML, et al. Management of accidental hypothermia: a narrative review. Medicina intensiva, 2019.PMID 30683520
- [17]Darocha T, et al. Accidental hypothermia. Nature reviews. Disease primers, 2026.PMID 42393082
- [18]Wall CR Myxedema coma: diagnosis and treatment. American family physician, 2000.PMID 11130234
- [19]Auer M, et al. [Thyroid Storm and Myxedema Coma]. Deutsche medizinische Wochenschrift (1946), 2025.PMID 40690932
- [20]Troutman GS, et al. Cold at the core: Osborn waves in neurosarcoidosis-induced central hypothermia. Case reports in cardiology, 2019.PMID 30766734