GP · respiratory-health
COPD
Also known as Chronic obstructive pulmonary disease · Chronic airflow obstruction · Emphysema and chronic bronchitis
GP-fellowship guide to COPD: the post-bronchodilator spirometric definition and GOLD grading, A/B/E assessment groups, the differential against asthma and asthma-COPD overlap, smoking cessation as the only disease-modifying intervention (varenicline, NRT, bupropion), the inhaled therapy ladder with the IMPACT/ETHOS/WISDOM/FLAME trial evidence defining who gets ICS, exacerbation management (steroids, antibiotics per Anthonisen criteria, NIV), long-term oxygen thresholds, vaccination, comorbidities and lung-volume reduction referral pointers.
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Red flags
- Any smoker over 40 with exertional dyspnoea, chronic cough or sputum needs spirometry — COPD is silent for years and under-diagnosis is the rule, but do not screen asymptomatic adults (USPSTF: no net benefit)
- A patient on triple therapy with recurrent pneumonia is being harmed by ICS — check eosinophils and exacerbation history before continuing; ICS withdrawal was safe in most patients without eosinophilia (WISDOM)
- New ankle oedema or rising haematocrit in advanced COPD signals cor pulmonale or chronic hypoxaemia — arterial gases and an oxygen assessment are due now
- Uncontrolled oxygen or a rising CO2 with falling consciousness in an exacerbation means NIV now — hypercapnic acidosis is the emergency that masks as 'just breathless'
Overview
COPD is the dominant chronic respiratory disease worldwide. In 2017, 544.9 million people had a chronic respiratory disease, chronic respiratory diseases were the third leading cause of death (7.0% of all deaths), and most of that death and disability burden was due to COPD.[4] Smoking was the leading risk factor for chronic respiratory disease-related disability in men across all regions.[4] Almost all of this burden passes through general practice: diagnosis, cessation, inhaler therapy, exacerbation management and end-of-life planning are primary-care work.
The natural history frames every intervention. FEV1 falls gradually over a lifetime, but in susceptible smokers it falls faster; smoking causes irreversible obstructive changes, and stopping smoking does not restore lost lung function — it reverts the rate of further loss to normal.[3] That is why cessation is the only disease-modifying intervention in COPD, and why it belongs in every consultation with every patient who smokes.
References27ShowHide
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