Anaes Vivas · Applied cardiovascular & respiratory physiology
Data viva — context-sensitive half-time graph
A Primary data viva — read a CSHT-vs-infusion-duration graph; define the CSHT; explain the flat ester curve (remifentanil), the moderate propofol curve, and the steep lipophilic curves (thiopental, fentanyl); give the clinical implications.
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Prompt
A Primary data viva — read a CSHT-vs-infusion-duration graph; define the CSHT; explain the flat ester curve (remifentanil), the moderate propofol curve, and the steep lipophilic curves (thiopental, fentanyl); give the clinical implications.
Stimulus
A graph shows context-sensitive half-time (Y-axis, log scale) plotted against infusion duration (X-axis) for remifentanil, propofol, thiopental and fentanyl. Interpret the graph, define the CSHT, and explain why each drug's curve has the shape it does.
References4ShowHide
- [1]Dong Y. Remimazolam in anesthesia and sedation: A narrative review. J Anesth Transl Med, 2025.PMID 41929379
- [2]Nagasaka Y. [Efficacy and safety of remifentanil-based regimen for postoperative pain management in abdominal surgery patients: a double-blind study with low-dose remifentanil infusion of 0.02 microg x kg(-1) x min(-1)]. Masui, 2014.PMID 24783622
- [3]Davis PJ. Ultra-short-acting opioids in paediatric anaesthesia: the role of remifentanil. Clin Pharmacokinet, 2005.PMID 16029065
- [5]Hohne C. [Opioids during anesthesia in liver and renal failure]. Anaesthesist, 2004.PMID 15074320