Anaes SAQs · Applied cardiovascular & respiratory physiology
The control of ventilation
Primary — medullary centres (DRG/VRG) and pontine shaping; central chemoreceptors (ventral medulla, CO2/H+ in CSF) the dominant drive; peripheral carotid/aortic bodies (PaO2, CO2, pH) and the hypoxic response; CO2-response curve; lung stretch/irritant/J/proprioceptor reflexes; volatile-anaesthetic depression; COPD oxygen-induced hypercapnia.
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ANZCAFRCAABAEDAIC
Prompt
Describe the chemical control of ventilation. Explain the roles of the central and peripheral chemoreceptors and the effect of anaesthesia on ventilatory control.
Question
Describe the chemical control of ventilation. Explain the roles of the central and peripheral chemoreceptors and the effect of anaesthesia on ventilatory control.[2]
References4ShowHide
- [1]Teppema LJ, Dahan A The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis. Physiol Rev, 2010.PMID 20393196
- [2]Guyenet PG Regulation of breathing and autonomic outflows by chemoreceptors. Compr Physiol, 2014.PMID 25428853
- [3]van den Elsen M, Sarton E, Teppema L, et al. Influence of 0.1 minimum alveolar concentration of sevoflurane, desflurane and isoflurane on dynamic ventilatory response to hypercapnia in humans. Br J Anaesth, 1998.PMID 9602581
- [4]Aubier M, Murciano D, Milic-Emili J, et al. Effects of the administration of O2 on ventilation and blood gases in patients with chronic obstructive pulmonary disease during acute respiratory failure. Am Rev Respir Dis, 1980.PMID 6778278