Anaes SAQs · TIVA & target-controlled infusion
The compartment model and target-controlled infusion
Primary-viva (basic-science) question on the compartment model underlying TCI: the central and peripheral compartments, context-sensitive half-time, effect-site targeting, and the named propofol models.
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Prompt
Describe the three-compartment pharmacokinetic model on which target-controlled infusion of propofol is based, and explain the concepts of context-sensitive half-time and effect-site targeting.
Question
Describe the three-compartment pharmacokinetic model on which target-controlled infusion of propofol is based, and explain the concepts of context-sensitive half-time and effect-site targeting[5][2].
References5ShowHide
- [1]Ye J, et al. A Prospective Study of Marsh PK-PD Model and Schnider PK-PD Model During Anesthesia Induction for Obese Patients Undergoing Elective Heart Surgery. Pharmacol Res Perspect, 2026.PMID 42286797
- [2]Introna M, et al. Target concentrations of propofol predicted by four different pharmacokinetic/pharmacodynamic models to induce loss of consciousness in neurosurgical patients. J Anesth Analg Crit Care, 2026.PMID 42231496
- [3]Lybbert C, et al. Correction: Clinical validation of an adapted Eleveld Model for high-dose propofol treatments for depression. J Clin Monit Comput, 2026.PMID 42360600
- [4]Bartošová T, Šíma M, Prskavec T, et al. Deep hypothermia reduces the predictive accuracy of the Eleveld propofol model: Population pharmacokinetic modelling in cardiac surgery. Biomed Pharmacother, 2026.PMID 42140058
- [5]Sahinovic MM, et al. Clinical Pharmacokinetics and Pharmacodynamics of Propofol. Clin Pharmacokinet, 2018.PMID 30019172