Anaes SAQs · TIVA & target-controlled infusion
The effect-site targeting and the ke0
Primary — the effect-site (the brain); the ke0 (the equilibration rate constant); the peak effect time; the faster equilibration; the more clinically relevant.
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ANZCAFRCAABAEDAIC
Prompt
Explain the concept of the effect-site targeting, the ke0, and the clinical advantages over the plasma targeting.
Question
Explain the concept of the effect-site targeting, the ke0, and the clinical advantages over the plasma targeting. (Question stem restated — the worked answers below carry the primary-source citations.)
References1ShowHide
- [1]Keresztes M, et al. Target-Controlled Infusion for Caesarean Delivery Under General Anesthesia: From Conventional Pharmacokinetic Models to Physiologically Based Pharmacokinetic Modeling. Life, 2026.PMID 42195295