Anaes SAQs · Applied cardiovascular & respiratory physiology
Splanchnic and GI physiology
Primary — splanchnic arteries (celiac, SMA, IMA) and portal vein; splanchnic blood flow 25 percent of CO; gut ischaemia in shock and barrier failure (motor of MOF); gastric acid secretion (parietal cell, proton pump, three stimuli); portal vein first-pass metabolism; gut-brain axis and POCD.
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Prompt
Describe the splanchnic circulation and the gut barrier. Explain the significance of the portal system for drug pharmacokinetics and the concept of the gut-brain axis in perioperative care.
Question
Describe the splanchnic circulation and the gut barrier. Explain the significance of the portal system for drug pharmacokinetics and the concept of the gut-brain axis in perioperative care.
[5]References4ShowHide
- [1]Narita T, et al. Surrogate measure of gut blood flow via superior mesenteric circulation on ultrasound in adults who underwent esophagectomy: A descriptive cohort study. JPEN, 2026.PMID 41620832
- [3]Yang Y, et al. [Lactate induces gastric mucosal injury by promoting M1 polarization of macrophages via the cardio-gastric axis]. J South Med Univ, 2026.PMID 42343836
- [5]Abdullah IA, et al. Gut-Brain Axis and Perioperative Gut Microbiome in Postoperative Cognitive Dysfunction: Implications for Neurosurgical Patients. Med Sci, 2025.PMID 41133518
- [2]Galsgaard KD, et al. GLP-2 and GIP acutely increase superior mesenteric artery blood flow in male rats, and the effect is independent of nitric oxide and vasoactive intestinal peptide. Physiol Rep, 2025.PMID 41388842