Anaes SAQs · Intravenous induction agents
Propofol — pharmacology and propofol infusion syndrome
Final SAQ — propofol: GABA-A potentiation with chloride hyperpolarisation; redistribution-driven recovery, clearance about 2.2 L/min with 40 percent extrahepatic, favourable context-sensitive decrement; dose-dependent hypotension via sympathetic loss plus baroreflex inhibition with preserved contractility; PRIS over 4 mg/kg/hour or beyond 48 hours with mitochondrial failure.
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ANZCAFRCAABAEDAIC
Prompt
Outline the pharmacology of propofol. Describe its mechanism of action, pharmacokinetics, cardiovascular effects and the propofol infusion syndrome.
Question
Outline the pharmacology of propofol. Describe its mechanism of action, pharmacokinetics, cardiovascular effects and the propofol infusion syndrome.[1]
References2ShowHide
- [1]Sahinovic MM, Struys MMRF, et al. Clinical Pharmacokinetics and Pharmacodynamics of Propofol. Clin Pharmacokinet, 2018.PMID 30019172
- [2]Singh A, Anjankar AP. Propofol-Related Infusion Syndrome: A Clinical Review. Cureus, 2022.PMID 36407194