Anaes SAQs · Intravenous induction agents
Pharmacokinetics of the intravenous induction agents — redistribution
A Primary basic-science pharmacokinetics question on the onset and offset of intravenous induction agents, redistribution versus metabolism, and the context-sensitive half-time.
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Prompt
Explain why an intravenous induction agent produces unconsciousness within seconds and yet allows the patient to wake within minutes, despite the drug not being metabolised in that time. Describe the three-compartment model and the concept of context-sensitive half-time.
Question
Explain why an intravenous induction agent produces unconsciousness within seconds and yet allows the patient to wake within minutes, despite the drug not being metabolised in that time. Describe the three-compartment model and the concept of context-sensitive half-time.
References3ShowHide
- [1]Hughes MA, Glass PSA, Jacobs JR. Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology, 1992.PMID 1539843
- [2]Burch PG, Stanski DR The role of metabolism and protein binding in thiopental anesthesia. Anesthesiology, 1983.PMID 6824168
- [3]Sahinovic MM, Struys MMRF, Absalom AR Clinical Pharmacokinetics and Pharmacodynamics of Propofol. Clinical pharmacokinetics, 2018.PMID 30019172