Anaes SAQs · Applied cardiovascular & respiratory physiology
Neuromuscular junction physiology
Primary — ACh vesicle release (calcium), nicotinic receptor and end-plate potential, acetylcholinesterase termination, T-tubule/DHP/ryanodine excitation-contraction coupling, suxamethonium (depolarising) vs rocuronium (competitive), neostigmine (anticholinesterase) and sugammadex (encapsulation), myasthenia gravis and Lambert-Eaton.
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ANZCAFRCAABAEDAIC
Prompt
Describe the sequence of events at the neuromuscular junction from motor nerve action potential to muscle contraction. Explain the mechanism of action of a depolarising and a non-depolarising neuromuscular blocker and their reversal.
Question
Describe the sequence of events at the neuromuscular junction from motor nerve action potential to muscle contraction. Explain the mechanism of action of a depolarising and a non-depolarising neuromuscular blocker and their reversal.
[1]References4ShowHide
- [1]Wood SJ, Slater CR. Safety factor at the neuromuscular junction. Prog Neurobiol, 2001.PMID 11275359
- [2]Sato M, et al. Suspected Neostigmine-Associated Bronchospasm Complicated by Pulmonary Edema During General Anesthesia: A Case Report. Cureus, 2026.PMID 42311723
- [5]Ishihara H, et al. Anaphylaxis After a Third Exposure to Sugammadex. Anesth Prog, 2025.PMID 41905390
- [3]Jiang L, et al. Efgartigimod for generalized myasthenia gravis: a comprehensive review of clinical evidence and future perspectives. Front Neurol, 2026.PMID 42358938