Anaes SAQs · Local anaesthetic pharmacology
Amide and ester local anaesthetics
Short-answer question on local-anaesthetic chemistry, ester vs amide, and structure-activity relationships.
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Prompt
Classify local anaesthetics into amides and esters, describe how their chemistry determines their metabolism and allergy risk, and outline the structure-activity relationships that govern potency, onset and duration.
Question
Classify local anaesthetics into amides and esters, describe how their chemistry determines their metabolism and allergy risk, and outline the structure-activity relationships that govern potency, onset and duration.
References6ShowHide
- [1]Galata Z, et al. Local anesthetic hypersensitivity: Frequently suspected, rarely proven: A retrospective study of 101 patients. Allergy Asthma Proc, 2026.PMID 42343493
- [2]Chooklin S, et al. In Search of Ideal Analgesia: Classical and Deep Rectus Sheath Block in Laparoscopic Cholecystectomy. Local Reg Anesth, 2026.PMID 42358227
- [3]Ogu E, et al. The Effect of Liposomal Bupivacaine and Obesity on Postoperative Opioid Consumption in Children With Scoliosis. J Pediatr Orthop, 2026.PMID 42351400
- [4]Little K. Guidelines in Practice: Local-Only Anesthesia. AORN J, 2026.PMID 42360750
- [5]Çopur İ, et al. Association Between Local Anesthetic Volume-Dose Combinations and Optic Nerve Sheath Diameter as an Indirect Marker of Intracranial Pressure During Ultrasound-Guided Supraclavicular Brachial Plexus Block: A Randomized Trial. Medicina (Kaunas), 2026.PMID 42356116
- [6]de Souza PMF, et al. Opioid-sparing analgesia with clonidine versus fentanyl in inguinal hernia repair: a randomized clinical trial. Hernia, 2026.PMID 42364024