Anaes SAQs · Local anaesthetic systemic toxicity
The LAST — the presentation and the prevention
Primary — the early CNS signs (the circumoral tingling, the metallic taste, the agitation); the late (the seizure, the cardiac arrest); the prevention (the ultrasound, the aspiration, the fractionation, the dose limits, the patient factors).
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Prompt
Describe the clinical presentation of the LAST and the measures to prevent it.
Question
Describe the clinical presentation of the LAST and the measures to prevent it.
References3ShowHide
- [1]Pham DT, et al. New long-acting local anesthetics: safety. Curr Opin Anaesthesiol, 2026.PMID 42228505
- [3]Uysal AI, et al. Local anesthesia: safety and limitations. Aesthet Plast Surg, 2026.PMID 41559381
- [42228506]Bersten AD, Soni N (eds) Oh's Intensive Care Manual. 8th edition, Elsevier, 2018.