Anaes SAQs · Local anaesthetic systemic toxicity
The lipid rescue for the LAST
Primary — the 1.5 mL/kg bolus + 0.25 mL/kg/min infusion; the 12 mL/kg max; the repeat bolus; the mechanism (the lipid sink); the prolonged CPR; the avoid vasopressin/CCBs/beta-blockers; the small adrenaline boluses.
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ANZCAFRCAABAEDAIC
Prompt
Describe the Intralipid 20 per cent rescue protocol for the LAST, including the doses, the mechanism, and the modifications to the standard ALS.
Question
Describe the Intralipid 20 per cent rescue protocol for the LAST, including the doses, the mechanism, and the modifications to the standard ALS.[1]
References2ShowHide
- [1]Weinberg GL Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose. Anesthesiology, 2012.PMID 22627464
- [2]Motayagheni N, Phan S, Nozari A, et al. Lipid Emulsion, More Than Reversing Bupivacaine Cardiotoxicity: Potential Organ Protection. J Pharm Pharm Sci, 2017.PMID 29145932