Psych CASC / OSCE · Psychopharmacology — rTMS, VNS and DBS
Explaining rTMS vs implants vs ECT for TRD (CASC)
CASC-style communication station: shared decision on rTMS first for outpatient TRD, honest VNS/DBS evidence, ECT comparator, safety and realistic expectations.
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Target exams
Station instructions (candidate)
You have 7 minutes. Explain why, after several adequate antidepressant failures, rTMS/iTBS is a reasonable next outpatient option: how sessions work (daily weeks; optional shorter iTBS), common side effects (scalp discomfort, headache; rare seizure), need for safety screening, and realistic response rates — not a guaranteed cure. Briefly place VNS (implant, delayed benefit, mixed acute RCT vs longer-term data) and DBS (specialist research; major controlled trials for key targets did not meet primary endpoints) so 'more invasive' is not sold as 'more proven'. Compare with ECT without stigma theatre: ECT remains important for more severe or urgent presentations and for some who do not respond to rTMS. Check understanding; invite questions; offer written information and crisis contacts.[1][2][3][4][5][6]
References6ShowHide
- [1]O'Reardon JP, Solvason HB, Janicak PG, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial Biol Psychiatry, 2007.PMID 17573044
- [2]Blumberger DM, Vila-Rodriguez F, Thorpe KE, et al. Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial Lancet, 2018.PMID 29726344
- [3]Rush AJ, Marangell LB, Sackeim HA, et al. Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial Biol Psychiatry, 2005.PMID 16139580
- [4]Aaronson ST, Sears P, Ruvuna F, et al. A 5-Year Observational Study of Patients With Treatment-Resistant Depression Treated With Vagus Nerve Stimulation or Treatment as Usual: Comparison of Response, Remission, and Suicidality Am J Psychiatry, 2017.PMID 28359201
- [5]Holtzheimer PE, Husain MM, Lisanby SH, et al. Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial Lancet Psychiatry, 2017.PMID 28988904
- [6]Milev RV, Giacobbe P, Kennedy SH, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 4. Neurostimulation Treatments Can J Psychiatry, 2016.PMID 27486154