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Psych CASC / OSCEPsychopharmacology — rTMS, VNS and DBS

Psych CASC / OSCE · Psychopharmacology — rTMS, VNS and DBS

Explaining rTMS vs implants vs ECT for TRD (CASC)

CASC-style communication station: shared decision on rTMS first for outpatient TRD, honest VNS/DBS evidence, ECT comparator, safety and realistic expectations.

communication2 min readVerification in progress

Target exams

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Target exams

FRANZCPMRCPsychABPNMD-DNB
Prompt
A 48-year-old man with treatment-resistant depression and his partner ask about 'TMS magnets', 'the vagus pacemaker', and 'deep brain electrodes'. They fear ECT memory loss, want a guaranteed cure, and wonder if implants are better because they are 'more high-tech'.

Station instructions (candidate)

You have 7 minutes. Explain why, after several adequate antidepressant failures, rTMS/iTBS is a reasonable next outpatient option: how sessions work (daily weeks; optional shorter iTBS), common side effects (scalp discomfort, headache; rare seizure), need for safety screening, and realistic response rates — not a guaranteed cure. Briefly place VNS (implant, delayed benefit, mixed acute RCT vs longer-term data) and DBS (specialist research; major controlled trials for key targets did not meet primary endpoints) so 'more invasive' is not sold as 'more proven'. Compare with ECT without stigma theatre: ECT remains important for more severe or urgent presentations and for some who do not respond to rTMS. Check understanding; invite questions; offer written information and crisis contacts.[1][2][3][4][5][6]

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You have read the opening of this CASC / OSCE. The complete unit — every section and its primary-source references — is part of the Psychiatry Fellowship fellowship library.

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References6ShowHide
  1. [1]O'Reardon JP, Solvason HB, Janicak PG, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial Biol Psychiatry, 2007.PMID 17573044
  2. [2]Blumberger DM, Vila-Rodriguez F, Thorpe KE, et al. Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial Lancet, 2018.PMID 29726344
  3. [3]Rush AJ, Marangell LB, Sackeim HA, et al. Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial Biol Psychiatry, 2005.PMID 16139580
  4. [4]Aaronson ST, Sears P, Ruvuna F, et al. A 5-Year Observational Study of Patients With Treatment-Resistant Depression Treated With Vagus Nerve Stimulation or Treatment as Usual: Comparison of Response, Remission, and Suicidality Am J Psychiatry, 2017.PMID 28359201
  5. [5]Holtzheimer PE, Husain MM, Lisanby SH, et al. Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial Lancet Psychiatry, 2017.PMID 28988904
  6. [6]Milev RV, Giacobbe P, Kennedy SH, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 4. Neurostimulation Treatments Can J Psychiatry, 2016.PMID 27486154
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