Phys · general-medicine
Undifferentiated Palpitations — Diagnostic Challenge
Also known as palpitations · awareness of heartbeat · pounding heart · racing heart · missed beats · extra beats · ectopic beats · fluttering chest · undifferentiated palpitations diagnostic approach · palpitation workup
Consultant-physician guide to the patient presenting with undifferentiated palpitations — the awareness of heartbeat — at FRACP DWE and DCE depth: the four-descriptor classification (regular fast, irregular, missed beat or extra beat, forceful pounding), the discriminating history (sudden versus gradual onset and offset, polyuria after termination pointing to SVT, exercise provocation pointing to VT or structural disease, the family history of sudden death pointing to a channelopathy), the cardiovascular and thyroid examination, the mandatory 12-lead ECG interpretation (AF, SVT, VT, long QT, WPW delta wave, Brugada pattern, LVH, ischaemia), the tiered ambulatory ECG strategy matched to symptom frequency (Holter for daily, event monitor for weekly, implantable loop recorder for monthly or rarer), the echocardiogram for structural disease, the electrophysiology study, and the cause-directed management (vagal manoeuvres, AV nodal blockers and catheter ablation for SVT, rate or rhythm control and anticoagulation for AF, urgent cardiology referral and ICD for VT, specialist evaluation for the channelopathies and cardiomyopathies) — with the DCE long-case and short-case presentation templates, the examiner discussion questions, and the classic exam traps.
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Red flags
- A patient with palpitations and syncope, or palpitations on exertion in a patient with structural heart disease, has a high-risk presentation requiring urgent cardiology referral and exclusion of ventricular tachycardia — these features carry a significant risk of sudden cardiac death
- A patient with a family history of sudden cardiac death under the age of 40, palpitations, and a long QT interval on the ECG has a channelopathy (long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia) requiring specialist evaluation, beta-blockade and consideration of an ICD
- A patient with a regular broad-complex tachycardia on the ECG should be assumed to have ventricular tachycardia until proven otherwise — do not assume SVT with aberrancy in a haemodynamically stable patient, especially with a history of ischaemic heart disease
- A patient with Wolff-Parkinson-White syndrome who develops atrial fibrillation is at risk of degeneration to ventricular fibrillation if the accessory pathway has a short antegrade refractory period — do not give AV nodal blocking agents (verapamil, adenosine, beta-blockers, digoxin) in pre-excited AF, as they preferentially block the AV node and accelerate conduction down the accessory pathway
- A patient with palpitations, chest pain, dyspnoea and haemodynamic instability requires immediate assessment for a tachyarrhythmia or bradyarrhythmia causing cardiovascular compromise — synchronised DC cardioversion if unstable tachycardia, transcutaneous pacing if unstable bradycardia
Undifferentiated Palpitations — Diagnostic Challenge
Meet the patient
A 28-year-old woman is sent by her GP for "funny turns". Every few weeks her heart "switches on" to a fast regular pounding while she sits at her desk, lasts ten minutes, then "switches off" the moment she bends and strains — and an hour later she passes a flood of dilute urine. Between attacks she is well, her examination is normal, and her resting ECG is normal.[1]
Two questions decide her, and they decide every palpitation: what is the rhythm during the symptom? and is she in the dangerous five? Hold those two and the whole topic slots into place — the four-descriptor fork narrows the differential before any test, the ECG confirms the substrate, and monitoring matches to frequency.[1]
References10ShowHide
- [1]Page RL, Joglar JA, Caldwell MA, Calkins H, Conti JB, Deal BJ, et al. 2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society J Am Coll Cardiol, 2016.PMID 26409258
- [2]Calkins H The 2019 ESC Guidelines for the Management of Patients with Supraventricular Tachycardia Eur Heart J, 2019.PMID 31837143
- [3]Hindricks G, Potpara T, Dagres N, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC Eur Heart J, 2021.PMID 32860505
- [4]Appelboam A, Reuben A, Mann C, et al. Postural modification to the standard Valsalva manoeuvre for emergency treatment of supraventricular tachycardias (REVERT): a randomised controlled trial Lancet, 2015.PMID 26314489
- [5]Abrams DJ Long QT syndrome Circulation, 2014.PMID 24709866
- [6]Link MS Clinical practice. Evaluation and initial treatment of supraventricular tachycardia N Engl J Med, 2012.PMID 23050527
- [7]Cohen MI, Triedman JK, Cannon BC, Davis AM, Drago F, Janousek J, et al. PACES/HRS expert consensus statement on the management of the asymptomatic young patient with a Wolff-Parkinson-White (WPW, ventricular preexcitation) electrocardiographic pattern: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology Foundation (ACCF), the American Heart Association (AHA), the American Academy of Pediatrics (AAP), and the Canadian Heart Rhythm Society (CHRS) Heart Rhythm, 2012.PMID 22579340
- [8]Pereira AR, Briosa A, Miranda R, et al. Sudden Cardiac Death: The Most Feared but Potentially Preventable Presentation of Wolff-Parkinson-White Syndrome Case Rep Cardiol, 2021.PMID 34840830
- [9]Fabian D, Ahmed I Ambulatory ECG Monitoring 2026.PMID 37983350
- [10]Nery PB, Belliveau D, Nair GM, et al. Relationship Between Pulmonary Vein Reconnection and Atrial Fibrillation Recurrence: A Systematic Review and Meta-Analysis JACC Clin Electrophysiol, 2016.PMID 29759868