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Phys Clinical Caseshepatic

Phys Clinical Cases · hepatic

Acute Liver Failure — Clinical Case

DCE long case for acute liver failure: a 19-year-old woman with Wilson disease acute liver failure presenting with jaundice, confusion and Coombs-negative haemolytic anaemia. Full patient assessment, SASPOP opening, structured problem list, integrated management plan (urgent transplant referral, chelation, cerebral oedema prophylaxis, no routine INR correction, genetic counselling), and probing examiner questions.

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FRACP DCEMRCP PACES
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FRACP DCEMRCP PACES
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DCE long case for acute liver failure: a 19-year-old woman with Wilson disease acute liver failure presenting with jaundice, confusion and Coombs-negative haemolytic anaemia. Full patient assessment, SASPOP opening, structured problem list, integrated management plan (urgent transplant referral, chelation, cerebral oedema prophylaxis, no routine INR correction, genetic counselling), and probing examiner questions.

Acute Liver Failure — Clinical Case

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References9ShowHide
  1. [1]O'Grady JG, Alexander GJM, Hayllar KM, Williams R Early indicators of prognosis in fulminant hepatic failure Gastroenterology, 1989.PMID 2490426
  2. [2]Lee WM Acute liver failure N Engl J Med, 1993.PMID 8305063
  3. [3]Ostapowicz G, Fontana RJ, Schiødt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States Ann Intern Med, 2002.PMID 12484709
  4. [4]Bernal W, Donaldson N, Wyncoll D, Wendon J Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study Lancet, 2002.PMID 11867109
  5. [5]Keays R, Harrison PM, Wendon JA, et al. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial BMJ, 1991.PMID 1954453
  6. [6]Lee WM, Hynan LS, Rossaro L, et al. Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure Gastroenterology, 2009.PMID 19524577
  7. [7]Stravitz RT, Lee WM Acute liver failure Lancet, 2019.PMID 31498101
  8. [8]Bernal W, Wendon J Acute liver failure N Engl J Med, 2013.PMID 24369077
  9. [9]Tujios SR, Stravitz RT, Lee WM Management of Acute Liver Failure: Update 2022 Semin Liver Dis, 2022.PMID 36001996
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