Paeds Vivas · gastroenterology-hepatology-and-nutrition
Parenteral nutrition and refeeding syndrome — branching viva
Branching viva from a malnourished adolescent with anorexia nervosa admitted for refeeding, through the definition and risk stratification of refeeding syndrome, the insulin-driven biochemistry, the thiamine and conservative-calorie prevention, the daily electrolyte monitoring, and on to a premature infant on long-term parenteral nutrition with a rising conjugated bilirubin where the composition streams, the glucose infusion rate, the lipid strategy and the prevention of intestinal failure-associated liver disease are probed.
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Target exams
Opening — framing the problem
The examiner begins: a 15-year-old with anorexia nervosa is admitted for refeeding after six weeks of negligible intake and a 15 per cent weight loss, with a body mass index of 15. On day two the phosphate has fallen and she is oedematous. Talk me through your approach. [5]
I would frame this as a high-risk refeeding scenario. The combination of prolonged negligible intake, significant weight loss and a very low body mass index places her at the highest risk of refeeding syndrome. My priorities would be to confirm the risk, to have given thiamine before feeding, to have corrected the phosphate, potassium and magnesium, to start at a conservative calorie level and escalate slowly, and to check the electrolytes at least daily for the first week, because the phosphate fall and the oedema tell me the syndrome is already declaring itself. [5] [6]
You have read the opening of this viva. The complete unit — every section and its primary-source references — is part of the Paediatrics Fellowship fellowship atlas.
References6Show ledgerHide ledger
- [1]Joosten K; Embleton N; Yan W; et al ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Energy. Clin Nutr, 2018.PMID 30078715
- [3]Mihatsch WA; Braegger C; Bronsky J; et al ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition. Clin Nutr, 2018.PMID 30471662
- [5]da Silva JSV; Seres DS; Sabino K; et al ASPEN Consensus Recommendations for Refeeding Syndrome. Nutr Clin Pract, 2020.PMID 32115791
- [6]Corsello A; Trovato CM; Dipasquale V; et al Refeeding Syndrome in Pediatric Age, An Unknown Disease: A Narrative Review. J Pediatr Gastroenterol Nutr, 2023.PMID 37705405
- [8]Lee WS; Chew KS; Ng RT; et al Intestinal failure-associated liver disease (IFALD): insights into pathogenesis and advances in management. Hepatol Int, 2020.PMID 32356227
- [9]Fundora J; Aucott SW Intestinal Failure-Associated Liver Disease in Neonates. Neoreviews, 2020.PMID 32873652