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Paeds Vivasgastroenterology-hepatology-and-nutrition

Paeds Vivas · gastroenterology-hepatology-and-nutrition

Parenteral nutrition and refeeding syndrome — branching viva

Branching viva from a malnourished adolescent with anorexia nervosa admitted for refeeding, through the definition and risk stratification of refeeding syndrome, the insulin-driven biochemistry, the thiamine and conservative-calorie prevention, the daily electrolyte monitoring, and on to a premature infant on long-term parenteral nutrition with a rising conjugated bilirubin where the composition streams, the glucose infusion rate, the lipid strategy and the prevention of intestinal failure-associated liver disease are probed.

branching clinical structured oral4 min readVerification in progress

Target exams

RACP General PaediatricsRACP DCEMRCPCH ClinicalRCPSC Pediatrics
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Target exams

RACP General PaediatricsRACP DCEMRCPCH ClinicalRCPSC Pediatrics
Prompt
You are the paediatric registrar on the ward. The examiner asks you to work through a 15-year-old with anorexia nervosa admitted for refeeding after six weeks of negligible intake, whose phosphate falls on day two, and later a premature infant on long-term parenteral nutrition whose conjugated bilirubin is rising. Information is released in stages.

Opening — framing the problem

The examiner begins: a 15-year-old with anorexia nervosa is admitted for refeeding after six weeks of negligible intake and a 15 per cent weight loss, with a body mass index of 15. On day two the phosphate has fallen and she is oedematous. Talk me through your approach. [5]

I would frame this as a high-risk refeeding scenario. The combination of prolonged negligible intake, significant weight loss and a very low body mass index places her at the highest risk of refeeding syndrome. My priorities would be to confirm the risk, to have given thiamine before feeding, to have corrected the phosphate, potassium and magnesium, to start at a conservative calorie level and escalate slowly, and to check the electrolytes at least daily for the first week, because the phosphate fall and the oedema tell me the syndrome is already declaring itself. [5] [6]

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References6ShowHide
  1. [1]Joosten K; Embleton N; Yan W; et al ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Energy. Clin Nutr, 2018.PMID 30078715
  2. [3]Mihatsch WA; Braegger C; Bronsky J; et al ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition. Clin Nutr, 2018.PMID 30471662
  3. [5]da Silva JSV; Seres DS; Sabino K; et al ASPEN Consensus Recommendations for Refeeding Syndrome. Nutr Clin Pract, 2020.PMID 32115791
  4. [6]Corsello A; Trovato CM; Dipasquale V; et al Refeeding Syndrome in Pediatric Age, An Unknown Disease: A Narrative Review. J Pediatr Gastroenterol Nutr, 2023.PMID 37705405
  5. [8]Lee WS; Chew KS; Ng RT; et al Intestinal failure-associated liver disease (IFALD): insights into pathogenesis and advances in management. Hepatol Int, 2020.PMID 32356227
  6. [9]Fundora J; Aucott SW Intestinal Failure-Associated Liver Disease in Neonates. Neoreviews, 2020.PMID 32873652
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